Mitochondrial and inflammatory biomarkers as promising tools to enrich the diagnosis of schizophrenia and bipolar disorder
A study of 934 individuals from the French I-GIVE cohort reveals that combining mitochondrial dysfunction markers (such as altered mtDNA copy number and lactate levels) with elevated inflammatory cytokines significantly improves the diagnostic accuracy for distinguishing schizophrenia and bipolar disorder from healthy controls, supporting their potential utility in refining psychiatric diagnosis and severity assessment.