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Vaccine gaps in Bundibugyo ebolavirus outbreak control and their implications for global public health preparedness and response

This study highlights the critical lack of licensed vaccines for Bundibugyo ebolavirus compared to Zaire ebolavirus, emphasizing that despite improved case fatality rates, outbreak control remains hindered by biomedical gaps and socioeconomic challenges, thereby necessitating sustained global investment in vaccine development and strengthened public health preparedness.

Frank Adusei-Mensah2026-07-25

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Risk-Stratified versus Cytology-Based Triage of Non-HPV 16/18-Positive for Detection of High-Grade Cervical Intraepithelial Neoplasia: Protocol of a Non- Inferiority Randomized Controlled Trial

The "STRAT-CIN Trial" is a non-inferiority randomized controlled trial protocol designed to evaluate whether a simplified risk-stratified triage algorithm using clinical and demographic factors is as effective as standard cytology for detecting high-grade cervical intraepithelial neoplasia (CIN2+) among women with non-HPV16/18 high-risk HPV infections in a resource-constrained Nigerian setting.

Kehinde S. OKUNADE, Omolola SALAKO, Adaiah SOIBI-HARRY, Iyabo Y. ADEMUYIWA, Nosimot O. DAVIES, Fatimah M. HABEEBU-ADEYEM (…)2026-07-25

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Clinical Application of Serum Gastrin-17 and Blood Lipid Indicators in the Screening of Colorectal Polyps

This retrospective study demonstrates that combining serum gastrin-17 and triglyceride levels improves the screening performance for colorectal polyps compared to individual markers, while carbohydrate antigens CA19-9 and CA50 show potential utility in distinguishing adenomatous from non-adenomatous polyps.

Shan Ni, Zhitong Shi, Qiyong Zhang, Xiaofeng Tang, Huiling Hu, Xiaoqin Chen, Xuyuan Zhang2026-07-25

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AI versus Expert Feedback on Ethical Decision-Making in Medical Students: A Pilot Randomized Controlled Feasibility Trial with Exploratory Educational Outcomes

This pilot randomized controlled trial demonstrates that AI-generated feedback is a feasible and acceptable alternative to expert panel feedback for medical ethics education, showing comparable or potentially superior preliminary outcomes despite baseline imbalances and the need for larger confirmatory studies.

Tuğba İş Kara, Yavuz Selim Kıyak2026-07-25

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Combination of CT and Plasma Long fragment cfDNA concentration improves diagnosis of pulmonary nodules

This study demonstrates that combining plasma long-fragment cfDNA concentration with CT imaging markers significantly improves the diagnostic accuracy for distinguishing malignant pulmonary nodules from benign ones, offering a promising multimodal approach for early lung cancer detection.

Yuheng Wen, Qinghua Yu, Xiaoqin Tan, Yong Zeng, Xuanchong Hu2026-07-25

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Evolution of clinicopathological features in patients with and without recanalization therapy before and after the introduction of thrombolysis

This retrospective autopsy study of 916 ischemic stroke patients reveals that while the introduction of reperfusion therapies significantly reduced thromboembolic complications, it was associated with a marked increase in hemorrhagic transformation, particularly among thrombolyzed patients.

Viktor Bencs, Lilla Hudák, Attila Csaba Nagy, Dénes Reviczki, Márk Kozák, Kitti Kovács, László Oláh, László Csiba2026-07-25

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Precision management of the ureteral tunnel via the Dual-Bridge technique during laparoscopic radical hysterectomy

This retrospective study demonstrates that the novel Dual-Bridge technique significantly improves surgical efficiency and reduces intraoperative blood loss during laparoscopic radical hysterectomy for cervical cancer by simplifying ureteral tunnel dissection, while maintaining safety comparable to conventional methods.

Yuquan Yuan, Xinru Xia, Shuai Diao, Yutong Wu, Yan Peng, Chunyan Ren, Jianrong Huang, Chengzhi Zhao2026-07-25

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Lens Opacity Area and Visual Outcomes in Unilateral Congenital Cataract Associated With Posterior Capsular Abnormalities Treated After Infancy: A Retrospective Case Series

This retrospective case series demonstrates that in unilateral congenital cataracts associated with posterior capsular abnormalities treated after infancy, a larger lens opacity area is significantly correlated with poorer visual acuity, loss of stereopsis, and greater thinning of the central inner retinal layers.

Miyuki Nagahara, Junko Nakagawa, Shigeko Yashiro, Yuuka Yamamoto, Miyuki Suga, Maiko Seki, Sawako Kato, Kentaro Nagahara2026-07-25

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Analysis of the Impact of Cervical and Breast Cancer Screening Results on Elderly Women’s Demand for Older adults Care Services: A Case Study of Guilin

This study proposes a low-cost, objective framework for assessing elderly women's differentiated care needs in Guilin by leveraging routine breast and cervical cancer screening data, revealing that while combined screening indicators effectively identify high-risk groups, the critically low participation of the oldest-old population necessitates improved service accessibility rather than reliance on limited risk data.

Shangyuhui Huang, Xue Wang, Yuanyuan He, Tao Jiang, Yanrui Chen, Wei Ma, Zhihua Wang2026-07-25

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Recovering Incomplete Clustered Binary Data in Longitudinal Electronic Health Records Using Multiple Imputation

This paper introduces and validates the Clustered Logistic Factor with Random Effects (CLF-RE) framework as a computationally scalable multiple imputation method that effectively recovers incomplete, high-dimensional longitudinal binary data in electronic health records, significantly reducing bias in epidemiologic estimates compared to existing approaches.

Pinyan Liu, John Rong Hao Tay, Gustavo G. Nascimento, Marco A. Peres2026-07-25

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