959 papers
This study identifies the POLR3A/ARG2/spermine axis as a critical driver of tamoxifen resistance in ERα+ breast cancer, demonstrating that pharmacological inhibition of spermine synthesis with DFMO can re-sensitize resistant tumors to tamoxifen by restoring Caspase2-mediated apoptosis.
By leveraging aquaculture models to decouple heritability from prediction stability, this study reveals that genomic prediction accuracy in hyper-diverse genomes is governed not by the total genetic variance explained, but by the evolutionary persistence of ancient, high-frequency variants with strong linkage disequilibrium.
The FourColon-Factors study is a protocol for a retrospective and prospective investigation at the Istituto Nazionale Tumori IRCCS in Naples to evaluate whether preoperative nutritional risk predicts anastomotic fistula and other outcomes in colorectal cancer surgery patients.
This study successfully translated and culturally adapted the Family Confusion Assessment Method (FAM-CAM) into Thai, demonstrating that the resulting instrument possesses excellent content validity and high diagnostic accuracy for detecting postoperative delirium in older surgical patients.
This study demonstrates that a benchtop 2D multi-pinhole X-ray imaging system using an energy-resolving detector can accurately quantify the intratumoral retention and biodistribution of 125I-labeled nanoparticles in mice, revealing high tumor selectivity and low off-target uptake to support preclinical optimization for nano-brachytherapy.
This study identifies serine demand as the critical factor governing the efficacy of PKM2 modulators, demonstrating that the novel compound SYX-PKM-A treats atopic dermatitis by activating PKM2 to restrict serine-dependent one-carbon metabolism in immune cells, thereby suppressing inflammation in high-serine-demand tissues like the skin.
This study demonstrates that a one-hour rest in a green space significantly reduces stress-related skin gas emissions (ammonia and allyl mercaptan) while increasing plant-derived monoterpenes in healthy individuals, suggesting that green environments modulate physiological stress responses and that skin gas analysis offers a non-invasive method for assessing such effects.
This study demonstrates that resveratrol significantly reduces the secretion of pro-inflammatory cytokines and angiogenic growth factors from ovarian cancer ascites-derived cells in a dose-dependent manner without affecting cell viability, suggesting its potential as an adjuvant therapy to target inflammation and angiogenesis in ovarian cancer.
This study utilizes a culturally responsive KAP model and fsQCA analysis to identify four distinct pathways and key elements that enhance the effectiveness of life skills education for Chinese university students, ultimately promoting their holistic development within campus health programs.
This study identifies three distinct latent profiles of social isolation among heart failure patients and demonstrates that employment status, sense of coherence, family closeness, and social support are significant influencing factors with cumulative effects across these subgroups.