959 papers
This prospective cohort study demonstrates that a first-trimester serum estradiol-to-testosterone ratio of ≤3.92 serves as a cost-effective, independent biomarker for predicting pre-eclampsia in low- and middle-income country settings, offering high sensitivity and a more than five-fold increased risk for affected women.
This study identified age, smoking, diabetes mellitus, hernia type, and intra-abdominal hypertension risk factors as independent predictors of contralateral occult inguinal hernia and successfully developed a validated nomogram model to effectively guide early screening and personalized treatment strategies for high-risk patients.
Contrary to the established pediatric "outdoor activity hypothesis," this NHANES-based study of U.S. individuals aged 12 and older reveals that outdoor and high-intensity physical activities are associated with a modestly increased risk of myopia in adults, suggesting that the protective effects of outdoor time observed in children do not extend to adult populations and may be confounded by factors like near-work and education.
In a triple-blind, randomized clinical trial involving 1,624 asymptomatic healthcare workers, the slow-release mucoadhesive paste "Mucodentol" (containing 3% Carvacrol) was found to significantly and progressively reduce the severity of COVID-19 symptoms compared to a placebo over a four-week period.
This study demonstrates that nested cross-validation significantly reduces optimism and provides more reliable performance estimates than single-split holdout or non-nested cross-validation when developing metabolomics-based predictive models for immune checkpoint inhibitor outcomes.
This retrospective study of 355 patients with upper gastrointestinal cancer recommended for best supportive care reveals a high symptom burden, short median survival of 69 days, and frequent hospital admissions, suggesting that structured follow-up could improve outcomes and reduce unplanned care.
This study demonstrates that C-GALAD is the most cost-effective biomarker-only strategy, and GALAD combined with ultrasound is also cost-effective, for early hepatocellular carcinoma screening in Chinese patients with HBV-related cirrhosis compared to conventional approaches.
This cross-sectional study of 2,825 outpatient visitors in Northern Cyprus reveals that while AI chatbots are widely used for health information, particularly by younger individuals, their impact on healthcare-seeking behavior is mixed due to low trust levels and concerns about potential delays in seeking professional medical care.
In very preterm infants, serum ferritin levels significantly increase while reticulocyte hemoglobin content remains stable during the first 14 days of life, suggesting that endogenous iron stores are generally sufficient to support hematopoiesis and that routine iron supplementation before day 14 may not be necessary.
This paper proposes a decision-responsive stopping rule for regulatory precedent research that synthesizes Value of Information, saturation, and capture–recapture frameworks to determine when sufficient evidence has been gathered for Target Product Profile and label development, demonstrating through GLP-1 case studies that fixed-volume approaches often lead to premature conclusions while context-aware methods align with the evolving regulatory landscape.