🔬 Category

pathology

32 papers

Pathology is the study of how diseases change the body, uncovering the hidden causes of illness and how they progress. From examining tissue samples to understanding molecular shifts, this field bridges the gap between basic science and patient care, offering crucial insights into everything from infections to cancer.

On Gist.Science, we track every new preprint in this vital area as it appears on bioRxiv and medRxiv. Our team processes these fresh findings to provide both clear, plain-language explanations and detailed technical summaries, ensuring that complex discoveries are accessible to everyone. Below are the latest pathology papers we have summarized from these leading servers.

A DEFINITIVE TCRBETA1/ TCRBETA2 ANTIBODY PAIR FOR DETERMINING T-CELL MONOTYPIA AS A SURROGATE FOR CLONALITY IN LYMPHOMA DIAGNOSIS IN FORMALIN FIXED PARAFFIN EMBEDDED MATERIAL

This study validates an improved pair of rabbit monoclonal antibodies against TCR{beta}1 and TCR{beta}2 for use in formalin-fixed, paraffin-embedded tissues, demonstrating their utility in immunohistochemical detection and automated ratio calculation as a rapid, spatially preserved surrogate for T-cell clonality in lymphoma diagnosis.

Kaistha, A., Situ, J. J., Evans, S. C., Ashton-Key, M., Ogg, G., Soilleux, E. J.2026-02-17🔬 pathology

3D Visualization and Proteomic Analysis of Human Cardiac Transthyretin Amyloidosis Tissue Reveals Microangiopathy and Capillary Occlusion

By combining 3D tissue imaging and proteomics, this study demonstrates that transthyretin amyloidosis (ATTR) cardiomyopathy is characterized by microangiopathy, including capillary thrombosis and dysregulated revascularization, which contributes to heart failure.

Donnelly, J. P., Schaefer, J.-H., Yoon, L., Massey, L., Ash, C., Gao, Z., Nugroho, K., Jaeger, M., Pang, Z., O'Neill, R. T., Maurer, M. S., Powers, E., Lander, G. C., Ye, L., Kelly, J. W.2026-02-11🔬 pathology