pathology papers | Gist.Science

Clinical and Immunohistochemical Determinants of Hepatocellular Carcinoma in Archival Liver Biopsies in Meru, Kenya

This study in Meru, Kenya, found that while clinical risk factors like HBV infection and hepatic fibrosis showed directional associations with hepatocellular carcinoma (HCC) without reaching statistical significance in a small cohort, the combined immunohistochemical marker pattern of Hep Par-1 positive and AE1/AE3 negative proved to be a highly accurate and valuable diagnostic tool for distinguishing HCC from metastatic liver carcinoma in resource-limited settings.

Kibera, J., Bender, J. B., Kobia, F. M. + 9 more2026-02-24🔬 pathology

Morphological set enrichment enables interpretable prognostication and molecular profiling of meningiomas

This study introduces Morphologic Set Enrichment (MSE), an interpretable AI framework that analyzes H&E histology to accurately predict genomic and epigenomic patterns in meningiomas, thereby providing independent prognostic value and redefining risk stratification beyond current WHO classification standards.

Ayad, M. A., McCortney, K., Congivaram, H. T. S. + 12 more2026-02-24🔬 pathology

SATB2/elastic lamina dual-staining in colon cancer: clinicopathological impact and prognostic value

This study demonstrates that SATB2/elastic lamina dual-staining is a reproducible method for detecting elastic lamina invasion (ELI) in pT3 colon cancer, where ELI positivity correlates with aggressive clinicopathological features and serves as an independent adverse prognostic indicator for reduced survival.

Jiang, B., Zhang, Y., Sheng, H. + 4 more2026-02-22🔬 pathology

TAZ (Wwtr1) deficiency leads to ER stress and mitochondrial dysfunction in a mouse model of Fuchs' endothelial corneal dystrophy

This study demonstrates that TAZ (Wwtr1) deficiency in a mouse model of Fuchs' endothelial corneal dystrophy drives corneal endothelial cell degeneration through age-dependent disruptions in mechanotransduction that trigger endoplasmic reticulum stress, mitochondrial dysfunction, and impaired protein organization, thereby establishing these mice as a vital platform for developing non-surgical therapies.

Park, S., Ramarapu, R., Lim, J. + 5 more2026-02-19🔬 pathology

Early sex-specific organ transcriptional divergence without physiological differences in a murine model of fecal-induced peritonitis

In a murine model of fecal-induced peritonitis, male and female mice exhibit identical physiological responses to early sepsis, yet transcriptomic analysis reveals that females display stronger immune activation and inflammatory responses in the kidney and lung compared to males.

Troitskaya, A., Gill, S. E., Manji, A. + 14 more2026-02-19🔬 pathology

Use of the novel PanLeucogated CD4 test has saved over 600 million USD for South Africas HIV treatment programme: A 20-year retrospective costing analysis (2004 to 2024)

A 20-year retrospective analysis reveals that South Africa's implementation of the cost-effective PanLeucogated CD4 test between 2004 and 2024 generated over $600 million in savings for its national HIV treatment program by replacing expensive conventional methods while enabling scalable, quality-assured monitoring.

Cassim, N., Stevens, W. S., Glencross, D. K. + 1 more2026-02-19🔬 pathology

Loss of the Coronary Artery Disease Risk Gene Leiomodin1 in Vascular Smooth Muscle Cells Triggers Rapid Onset Coronary Atherosclerosis

This study demonstrates that vascular smooth muscle cell-specific loss of the coronary artery disease risk gene Leiomodin1 triggers rapid, diffuse coronary atherosclerosis in mice through a thrombospondin-dependent mechanism that is independent of the protein's actin nucleation function.

Salem, A. R., Doja, J., Ge, C. + 17 more2026-02-18🔬 pathology

Value-Based Evidence Accumulation as a Transdiagnostic Marker of General Distress

This study identifies value-based evidence accumulation efficiency, measured by drift rate, as a transdiagnostic marker of general distress that is distinct from and more strongly associated with broad distress than with specific psychiatric symptom domains.

Pushkarskaya, H., Russell, C. M., Cheng, K. + 2 more2026-02-18🔬 pathology

SydneyMTL: Interpretable Multi-Task Learning for Complete Sydney System Assessment in Gastric Biopsies

SydneyMTL is a novel, interpretable multi-task deep learning framework trained on over 50,000 whole-slide images that simultaneously grades all five Updated Sydney System attributes for gastritis, demonstrating high agreement with expert consensus, preserving the biological ordinality of disease severity, and significantly improving diagnostic efficiency and consistency in clinical workflows.

Jeong, W. C., Kim, H. H., Hwang, Y. + 3 more2026-02-18🔬 pathology

Integrating Histologic Descriptors into the Ninth Edition TNM Staging Improves Prognostic Stratification of Lung Adenocarcinoma

This study demonstrates that integrating histologic descriptors such as histologic grade, lymphovascular invasion, and spread through air spaces into the ninth edition TNM staging system significantly improves prognostic stratification for lung adenocarcinoma, offering stage-dependent insights to refine future staging frameworks.

Abolfathi, H., Maranda-Robitaille, M., Lamaze, F. C. + 10 more2026-02-18🔬 pathology

Gene expression profiling of bovine raw milk as a new tool to monitor the inflammatory status of the udder : a pilot study

This pilot study demonstrates that gene expression profiling of raw milk using RT-qPCR can effectively differentiate milk samples based on specific immune cell types (neutrophils, macrophages, and T lymphocytes), offering a promising alternative to traditional somatic cell counting for monitoring the inflammatory status of the bovine udder.

Gitton, C., Le Vern, Y., Gaborit, M. + 2 more2026-02-17🔬 pathology

A DEFINITIVE TCRBETA1/ TCRBETA2 ANTIBODY PAIR FOR DETERMINING T-CELL MONOTYPIA AS A SURROGATE FOR CLONALITY IN LYMPHOMA DIAGNOSIS IN FORMALIN FIXED PARAFFIN EMBEDDED MATERIAL

This study validates an improved pair of rabbit monoclonal antibodies against TCR{beta}1 and TCR{beta}2 for use in formalin-fixed, paraffin-embedded tissues, demonstrating their utility in immunohistochemical detection and automated ratio calculation as a rapid, spatially preserved surrogate for T-cell clonality in lymphoma diagnosis.

Kaistha, A., Situ, J. J., Evans, S. C. + 3 more2026-02-17🔬 pathology

Dermatomycosis associated with Nannizziopsis arthrosporioides in a breeding colony of gecko (Correlophus ciliatus and Rhacodactylus auriculatus).

This paper reports the first documented fatal outbreak of *Nannizziopsis arthrosporioides*-associated dermatomycosis in a breeding colony of *Correlophus ciliatus* and *Rhacodactylus auriculatus* geckos, which occurred following the introduction of an infected individual from overseas.

Nagao, J., Hosoya, T., Nam, K.-O. + 3 more2026-02-16🔬 pathology

← Previous