39 papers
Pathology is the study of how diseases change the body, uncovering the hidden causes of illness and how they progress. From examining tissue samples to understanding molecular shifts, this field bridges the gap between basic science and patient care, offering crucial insights into everything from infections to cancer.
On Gist.Science, we track every new preprint in this vital area as it appears on bioRxiv and medRxiv. Our team processes these fresh findings to provide both clear, plain-language explanations and detailed technical summaries, ensuring that complex discoveries are accessible to everyone. Below are the latest pathology papers we have summarized from these leading servers.
This study reveals that hyperactivated glycolysis drives the early, spatially-patterned depletion of Kupffer cells during MASLD progression, establishing a causal link between enhanced glucose utilization and cell death that highlights metabolic pathways as potential therapeutic targets.
This study in Meru, Kenya, found that while clinical risk factors like HBV infection and hepatic fibrosis showed directional associations with hepatocellular carcinoma (HCC) without reaching statistical significance in a small cohort, the combined immunohistochemical marker pattern of Hep Par-1 positive and AE1/AE3 negative proved to be a highly accurate and valuable diagnostic tool for distinguishing HCC from metastatic liver carcinoma in resource-limited settings.
This study demonstrates that SATB2/elastic lamina dual-staining is a reproducible method for detecting elastic lamina invasion (ELI) in pT3 colon cancer, where ELI positivity correlates with aggressive clinicopathological features and serves as an independent adverse prognostic indicator for reduced survival.
In a murine model of fecal-induced peritonitis, male and female mice exhibit identical physiological responses to early sepsis, yet transcriptomic analysis reveals that females display stronger immune activation and inflammatory responses in the kidney and lung compared to males.
A 20-year retrospective analysis reveals that South Africa's implementation of the cost-effective PanLeucogated CD4 test between 2004 and 2024 generated over $600 million in savings for its national HIV treatment program by replacing expensive conventional methods while enabling scalable, quality-assured monitoring.
This study demonstrates that integrating histologic descriptors such as histologic grade, lymphovascular invasion, and spread through air spaces into the ninth edition TNM staging system significantly improves prognostic stratification for lung adenocarcinoma, offering stage-dependent insights to refine future staging frameworks.
This study validates an improved pair of rabbit monoclonal antibodies against TCR{beta}1 and TCR{beta}2 for use in formalin-fixed, paraffin-embedded tissues, demonstrating their utility in immunohistochemical detection and automated ratio calculation as a rapid, spatially preserved surrogate for T-cell clonality in lymphoma diagnosis.
By combining 3D tissue imaging and proteomics, this study demonstrates that transthyretin amyloidosis (ATTR) cardiomyopathy is characterized by microangiopathy, including capillary thrombosis and dysregulated revascularization, which contributes to heart failure.
This paper introduces an entropic framework for characterizing the training dynamics of neural networks in digital pathology, demonstrating that models develop reproducible, quantifiable internal structures—such as increasing activation modularity, reduced representation entropy, and attention shifts toward biologically relevant nuclear regions—that provide a mechanistic basis for interpreting how these systems acquire meaningful representations.