q-bio papers | Gist.Science

Sex-specific gut microbial and metabolic responses to inhaled diesel exhaust particle exposure are modified by probiotic treatment in C57BL/6 mice

This study demonstrates that inhaled diesel exhaust particle exposure induces sex-specific metabolic and gut microbiome disruptions in mice, with females showing heightened vulnerability, while probiotic supplementation differentially modifies these responses, highlighting the critical need to consider biological sex in environmental health research and microbiome-targeted interventions.

Victoria Youngblood, Tyler D. Armstrong, Kayla Nguyen-Alley, Amaya E. Green, Molly E. Kelly, Bailee Johnson, Analana Sta (…)2026-08-27

🧬 biology

Chiralify: A Framework for Fragmentation Modeling and Advanced Chiral Metabolite Annotation

Chiralify is an open-source cheminformatics framework that automates and scales the annotation and comparative analysis of enantiomeric metabolites by integrating fragmentation modeling with a spectral library, thereby enabling systematic stereochemical characterization in untargeted metabolomics workflows.

Ruggiero Gorgoglione, Valeria Impedovo, Yujin Lee, Alessia Lodi, Stefano Tiziani2026-08-27

🧬 biology

The Brain Extracellular Matrix as a Mechanical Signaling Platform: Soft Tissue, Strong Signals, Glycosaminoglycans and the Mechanical Logic of the Brain

This narrative review explores how the brain's soft extracellular matrix, particularly through evolutionarily conserved glycosaminoglycans and proteoglycans, functions as a critical mechanical signaling platform that regulates development, homeostasis, and cellular protection via mechanotransduction pathways.

James Melrose2026-08-27

🧬 biology

Multifaceted Biological Activities of Linalool: Antimicrobial, Antibiofilm, Cytotoxic, Antiproliferative and Pro-Apoptotic Effects

This study demonstrates that the natural monoterpene linalool exhibits broad-spectrum antimicrobial and antibiofilm activities against various pathogens while simultaneously inducing dose-dependent cytotoxicity, antiproliferation, and apoptosis in C6 glioma cells, highlighting its potential as a multifunctional bioactive compound.

Esra Bulut Atalay, Rukiye Aslan2026-08-27

🧬 biology

Impact of TLR3 Activation on Endothelial Functions: Insights into iNOS- Dependent Mechanisms

This study demonstrates that TLR3 activation impairs endothelial cell survival and induces mitochondrial dysfunction via an iNOS-dependent increase in ROS production, while simultaneously downregulating eNOS in an iNOS-independent manner, thereby identifying iNOS as a selective therapeutic target for TLR3-triggered vascular disorders.

Junchul Shin, Junyoung Hong, Soon-Gook Hong, Jinkyung Cho, Bruce D. Johnson, Olga A. Cherepanova, Chul-Ho Kim2026-08-27

🧬 biology

Soluble TREM2 Mediates Blood Brain Barrier Permeability through Astrocyte Reactivity

This study demonstrates that soluble TREM2 (sTREM2) compromises blood-brain barrier integrity by inducing an inflammatory, reactive state in astrocytes that upregulates MMP2 secretion, leading to the degradation of tight junction proteins and increased permeability.

Samuel Martinez-Meza, Brandon A. Sealy, Lillie Lopez, Douglas F. Nixon, Joan W. Berman2026-08-27

🧬 biology

Bat activity patterns during the deployment of a ground-mounted photovoltaic farm in a Mediterranean agricultural landscape: an exploratory multi-stage study

This exploratory study in central Italy reveals that bat activity patterns during the deployment of a ground-mounted photovoltaic farm are taxon-specific and spatially structured, showing no significant differences across construction phases within the facility but lower activity at the site compared to agricultural references in early seasons and higher activity along the illuminated perimeter in late summer.

Marta Cotti Piccinelli, Gianpasquale Chiatante, Stuart Connop, Chiara Baldacchini, Caroline Nash2026-08-27

🧬 biology

The live attenuated DGAT1-knockout whole-cell Toxoplasma vaccine confers protective immunity against acute and chronic toxoplasmosis

The study demonstrates that a live-attenuated *Toxoplasma gondii* vaccine strain lacking the DGAT1 enzyme is safe, induces robust mixed Th1/Th2 immunity, and confers complete, long-lasting protection against both acute type I and chronic type II toxoplasmosis in mice.

Isabelle Coppens, Shahbaz Khan, Yevel Flores-Garcia, Jiro Sakai, Mustafa Akkoyunlu, Julia Romano, Karen Ehrenman, Vivian (…)2026-08-27

🧬 biology

A Distinct Second Spectral Peak in White Matter BOLD Signals: Mathematical Modeling, Spatial Distribution and Age-Related Evolution

This study identifies and characterizes a robust, age-dependent "second peak" at approximately 0.06 Hz in white matter BOLD signals, proposing it as a novel, organized physiological phenotype linked to perivascular clearance mechanisms that offers new insights into white matter functional integrity and brain aging.

sijing wu, Muwei Li, Yurui Gao, Lyuan Xu, Yu Zhao, John C Gore, Zhaohua Ding2026-08-27

🧬 biology

HLA-B*57 as a Dominant Genetic Determinant of HIV-1 Elite Control: Comparative Reanalysis of MHC Variant Associations in European and African-American Cohort A reanalysis of published genomic association data

This reanalysis confirms HLA-B*57 as a dominant, dose-dependent genetic determinant of HIV-1 elite control in European populations while providing supportive enrichment evidence for its African-ancestry counterpart, HLA-B*57:03, and identifying eight additional independent MHC variants that warrant further investigation in diverse cohorts.

Emmanuel Owusu Frimpong2026-08-27

← Previous Next →