q-bio papers | Gist.Science

Integrated metabolomic and proteomic analyses reveal the regulatory mechanism of H-2-168 against Echinococcus granulosus infection in mice

This study employs integrated metabolomic and proteomic analyses to demonstrate that the harmine derivative H-2-168 alleviates *Echinococcus granulosus*-induced hepatic injury in mice by modulating key metabolic pathways, including tryptophan and sphingolipid metabolism, and regulating a complex network of proteins and metabolites involved in inflammation, oxidative stress, and ferroptosis.

Yixueying Ma, Qinwei Xu, Yujie Huang, Jinxin Li, Haoyuan Xu, Huijing Gao, Liang Teng2026-07-01

🧬 biology

High-fat diet Promotes Brain Renin–Angiotensin System Dysregulation, Neuroinflammation, and Anxiety-Like Behavior in Zebrafish

This study demonstrates that a high-fat diet induces obesity in zebrafish, leading to brain renin–angiotensin system dysregulation and neuroinflammation that collectively drive anxiety-like behaviors.

Mariana Torri Claro, Gabriel Teixeira De Macedo, Matheus Mülling dos Santos, Sabrina Antunes Ferreira, Talise Ellwanger (…)2026-07-01

🧬 biology

The insertion of Neomycin cassette impairs maternal and social behaviors in Arc/Arg3.1 knock-out mice

This study reveals that the commonly used Neomycin resistance cassette, rather than the Arc/Arg3.1 gene deletion alone, causes severe impairments in maternal and social behaviors in knockout mice by altering ERK signaling and the oxytocin system, thereby necessitating a critical re-evaluation of behavioral phenotypes in animal models retaining this genetic marker.

Lucie Pellissier, Ana Dudas, Emilia CAIRE, Abdurahman HASSAN A KUKU, Océane MARCHAND, Nicolas AZZOPARDI, Heba ELSEEDY, V (…)2026-07-01

🧬 biology

AMPK/SIRT1 Pathway is Involved in Selenoprotein H Mediated Protective Effects Against Hyperglycemia- Exacerbated Cerebral Ischemia Injury

This study demonstrates that sodium selenite alleviates hyperglycemia-aggravated cerebral ischemia/reperfusion injury by promoting mitochondrial biogenesis through the Selenoprotein H-mediated activation of the AMPK/SIRT1/PGC-1α signaling pathway.

Tianxiang Zheng, Shuai Zhao, Bolin Shi, Shengchao Ma, Yue Chang, Zhiyao Lian, Li Jing, Lan Yang2026-07-01

🧬 biology

Floral characters and ITS phylogeny provide robust species resolution in Indonesian Paphiopedilum

This study demonstrates that integrating floral morphology with nuclear ITS phylogeny provides the most robust framework for resolving species boundaries in Indonesian *Paphiopedilum*, offering critical tools for taxonomy, conservation, and breeding.

Eka Martha Della Rahayu, Muhammad Rifqi Hariri, Darda Efendi, Sintho Wahyuning Ardie, Ika Roostika, Sudarsono Sudarsono2026-07-01

🧬 biology

High-level Expression and Integrated Purification of Recombinant Human Type I+III Collagen in Pichia pastoris

This study establishes a robust, scalable, and cost-effective manufacturing platform for recombinant human type I+III collagen in *Pichia pastoris* by combining multi-copy integration, optimized high-density fermentation at 22°C, and an integrated purification process to achieve high yields (10.42 mg/mL) with ≥94.7% purity and ≥90% activity recovery in a 500 L pilot-scale bioreactor.

Lu Li, Yue Huang, Xin Fu, He Xiao, Yun Zhang, Huaiqing Sun, Chaowan Guo, Ying Lin2026-07-01

🧬 biology

SSR marker-based genetic diversity and population structure of large-leaf tea germplasm across four major tea-producing regions of Yunnan, China

This study utilized SSR markers to analyze 216 large-leaf tea accessions from four Yunnan regions, revealing abundant genetic diversity primarily within populations and weak regional differentiation driven by extensive gene flow and historical exchange, thereby providing a foundation for future conservation and breeding efforts.

Qihuan Ding, Wuxiang Fu, Ning Chi, Jianmei Su, Shanshan Wu, Zhanxia Ma2026-07-01

🧬 biology

GcQCR7 Mediates Pathogenicity via Maintaining Cell Wall Integrity and Enhancing Oxidative Stress Tolerance in Glomerella cingulata

This study demonstrates that the mitochondrial subunit GcQCR7 is essential for *Glomerella cingulata* pathogenicity by maintaining cell wall integrity, energy metabolism, and oxidative stress tolerance, thereby identifying it as a novel target for managing Glomerella leaf spot in apple production.

Mingjuan Yang, Xinyue Cui, Shan Zhang, Fang Wang, Weichao Ren, Pingliang Li, Na Liu, Baohua Li, Chengying Jiang, Sen Lia (…)2026-07-01

🧬 biology

Mechanosensing at the endoplasmic reticulum by IRE1

This study identifies the endoplasmic reticulum as an autonomous mechanosensitive organelle where the transmembrane protein IRE1 directly senses membrane tension to trigger JNK signaling and enhance global protein synthesis, thereby linking mechanical forces to muscle adaptation independently of its canonical unfolded protein response role.

Hesso Farhan, Michaela Mayr, Luiz Garcia-Souza, Murphy McDermott, Utku Horzum, Yannick Frey, Margot Haun, Stephan Geley (…)2026-07-01

🧬 biology

Transglutaminase 2 contributes to the blood clotting cascade

This study challenges the long-held view that Factor XIIIa is the sole transglutaminase responsible for clot stabilization by demonstrating that tissue transglutaminase (TG2) also plays a significant role in reinforcing blood clots and reducing fibrinolysis.

Gerry Melino, Mauro Piacentini, N Mutch, Alessandro Mauriello, Manuel Scimeca, Mara Mancini, Valerio Da Ros, Francesco B (…)2026-07-01

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