3881 papers
This study demonstrates that integrative multi-omics profiling combined with functional immune assays effectively distinguishes mild from severe systemic allergy phenotypes in both honeybee venom and olive pollen patients by revealing distinct, allergen-specific molecular and cellular signatures associated with disease severity.
This study demonstrates that reservoir computing performance is primarily governed by high clustering and low degree heterogeneity rather than small-world topology alone, revealing that human connectome-based networks underperform compared to optimized small-world networks on standard tasks.
This study reveals that in KRAS/STK11-mutant lung adenocarcinoma, glutamine deprivation triggers a metabolic rewiring that enhances hexosamine biosynthetic pathway flux, thereby promoting metastatic traits and challenging the therapeutic efficacy of glutamine deprivation strategies.
This study demonstrates that senescent type II alveolar epithelial cells, rather than macrophages, are the primary drivers of pulmonary fibrosis progression through the secretion of GDF15, highlighting a potential therapeutic target for idiopathic pulmonary fibrosis.
This study establishes a standardized framework using a Naïve Bayes classification model to harmonize and enable the quantitative comparison of mRNA poly(A) tail length distributions across LC–MS, LC–UV, and Oxford Nanopore sequencing platforms, thereby supporting regulatory alignment for mRNA therapeutics characterization.
This study reveals that the year-round leaf phenology of *Myrcia ovata* facilitates continuous gall induction by *Myrciamyia maricaensis*, while inquiline hypergallers subsequently restructure these primary galls through tissue hyperplasia and resource hijacking, thereby altering the developmental dynamics and life cycle of this multitrophic system.
This study reveals that pre-existing heterogeneity in MyD88 abundance within macrophages determines single-cell thresholds for innate immune activation, where strong agonists drive robust signaling and feedback termination while weak agonists lead to persistent low-output signaling, a mechanism of incomplete activation-feedback coupling that correlates with chronic inflammatory diseases like Alzheimer's.
This study demonstrates that chronic post-stroke adaptive immunity is characterized by a reproducible, organized, yet heterogeneous clonal expansion of both B and T cells within the infarct, revealing a structured multi-lineage immune response across diverse experimental conditions.
This study presents a physiology-based three-layer diffusion-reaction model parameterized solely by human in vitro data that successfully predicts clinical intravesical mitomycin C concentrations in the urothelium and lamina propria, offering a scientific basis for optimizing treatment regimens based on tissue exposure rather than empirical urinary metrics.
This study identifies and characterizes multiple longevity-adapted *Saccharomyces cerevisiae* strains evolved under high-glucose stress, revealing that while distinct lineages employ diverse transcriptional strategies, they converge on a shared metabolic remodeling of the tryptophan-kynurenine pathway and NAD+ networks to enhance survival and robustness.