3881 papers
Carboxymethylcellulose (CMC) ameliorates high-fat diet-associated colitis by suppressing *Bacteroides acidifaciens*-mediated deoxycholic acid production, which restores mitochondrial complex I function in macrophages and inhibits their M1 polarization.
This study presents high-quality genome sequences and phenotypic profiles, including antimicrobial susceptibility, for three *Parabacteroides* strains isolated from the feces of clinically healthy calves to address the understudied taxonomy of mammal-derived *Parabacteroides* species.
This study reveals a previously unknown mechanism where Cas12a nucleases can be activated independently of crRNA and PAM recognition by short RNAs, enabling programmable, amplification-free detection of nucleic acids through an alternative conformational state.
This study demonstrates that tuning lipid nanoparticle composition to favor less compact, low-order siRNA packing enhances endosomal fusion and cargo release, thereby significantly improving the functional delivery and silencing potency of siRNA therapeutics.
This study elucidates how the intrinsically disordered and coiled-coil domains of PABPN1 differentially regulate its aggregation and function in oculopharyngeal muscular dystrophy, and demonstrates that a naturally occurring, non-aggregating truncated isoform (trPAB) can restore protein activity and serve as a promising therapeutic strategy for the disease.
By meta-analyzing genome-wide association data from over 226,000 individuals, this study reveals that bipolar disorder's genetic architecture is hierarchical and multidimensional rather than subtype-based, identifying four distinct clinical factors, 356 risk loci, and a midbrain dopaminergic–GABAergic gradient that collectively explain the disorder's clinical heterogeneity.
This study demonstrates that oxidative stress resistance, a key determinant of extended longevity in *Drosophila melanogaster*, is heritable and largely additive, with a pronounced and persistent maternal effect that enhances offspring survival, locomotor performance, and antioxidant defenses across generations.
This manuscript presents a comprehensive dataset comprising resting-state and task-based EEG recordings from 173 participants, including 87 confirmed COVID-19 survivors and 86 healthy close contacts, who were also subjected to detailed physical, neurological, and clinical evaluations.
This study identifies ANO5, FFAR4, and SMAD9 as shared key genes linking lung adenocarcinoma and type 2 diabetes through multi-omics analysis, revealing their roles in hormone and glucose metabolism, prognostic value, and potential as therapeutic targets.
This study demonstrates that higher subclinical autistic traits are associated with attenuated prefrontal hemodynamic responses and reduced neural differentiation between social and non-social contexts during live competitive gameplay, suggesting that dimensional autistic variation specifically impacts brain activity during reciprocal human interaction.