🧬 Category

q-bio

1686 papers

🧬 biology

Brain-region-aware genetic prioritization separates Alzheimer disease risk from APOE-sensitive β-amyloid burden in public genetic and expression quantitative trait locus resources

By integrating public genetic and expression resources, this study demonstrates that Alzheimer's disease risk and β-amyloid burden represent distinct biological processes, identifying BIN1 as a broad risk anchor while showing that the previously implicated ZNF227 signal is primarily driven by APOE-region variants rather than independent amyloid pathology.

Ran Chen, Xiaohui Bi2026-07-01
🧬 biology

Identification of Maize Fusarium Ear Rot Resistance Genes via Integrated BSA-Seq and RNA-Seq Analysis

This study integrates BSA-Seq, RNA-Seq, and WGCNA analyses to elucidate the molecular mechanisms of maize resistance to *Fusarium graminearum*, identifying eight resistance-associated loci and six high-confidence candidate genes involved in oxidative stress, hormone signaling, and cell wall modification that distinguish the resistant inbred line K0743 from the susceptible K0742.

Jiaqin Liu, Wei Zhao, Fangguo Chang, Wei Wang, Fang Wang, Chun Wang, Yaqiong Shi2026-07-01
🧬 biology

KLF6 Downregulation-Mediated Loss of LILRB4 Impairs Decidual Macrophage Tolerance During Toxoplasma gondii Infection

This study reveals that *Toxoplasma gondii* infection impairs maternal-fetal tolerance and causes adverse pregnancy outcomes by suppressing the pSTAT3/KLF6 axis, which downregulates LILRB4 on decidual macrophages and disrupts the IDO/iNOS immunoregulatory balance.

Xuemei Hu, Zhidan Li, Fan Zhang, Rutao Mou, Tianyu Jing, Zhendong Zhang, Xianbing Liu, Liqin Ren, Yuzhu Jiang, Haixia Zh (…)2026-07-01
🧬 biology

Simulation-Based Assessment of Cancer-Associated cfDNA Methylation and miRNA Profiles for Forensic Molecular Inference: A Proof-of-Concept Machine-Learning Study

This proof-of-concept machine learning study demonstrates that simulated circulating cell-free DNA methylation and miRNA profiles can achieve high accuracy in distinguishing cancer-associated from healthy molecular states, while explicitly emphasizing that these computational results do not validate operational forensic applications and require extensive wet-lab validation and ethical safeguards before any investigative use.

Melek Şenışık, Ahmet Murat Şenışık2026-07-01
🧬 biology

Proteomics Characteristics of Sciatic Nerves in Diabetic Peripheral Neuropathy, Key Gene DDI2 Identification and Comprehensive Therapeutic Strategy Exploration

This study identifies DDI2 as a key regulator of autophagy impairment in diabetic peripheral neuropathy through proteomic and transcriptomic analyses of db/db mouse sciatic nerves and RSC96 cells, proposing a comprehensive therapeutic strategy involving the natural compounds fraxetin and cytisine, as well as ATF3 overexpression, to restore autophagic flux and reverse metabolic dysregulation.

Yue Gao, Qiuli Li, Yuting Bu, Tingting Jin, Chenming Zhou, Wandi Wei, Wenhui Li, Yuanyuan Sun, Lin Zhu, Jun Hao2026-07-01
🧬 biology

Impact of Optic Flow Charateristics in Virtual Reality on Vection and Visually Induced Motion Sickness

This study demonstrates that the impact of visual field of view on vection and motion sickness in virtual reality depends on the spatial reference frame and individual susceptibility, revealing that gravity-referenced framing effectively mitigates symptoms specifically for highly vection-sensitive users.

Adem Boudjemline, Clement Bougard, Jean-Marie Pergandi, Hadrien Ceyte, Lionel Bringoux2026-07-01
🧬 biology

Divergent Functions of Two AGL6 Homologs in Floral Meristem Transition and Organ Morphogenesis in London Plane Tree

This study characterizes two *AGL6* homologs in London plane tree (*Platanus acerifolia*), revealing that while both genes share similar expression patterns and promote precocious flowering when overexpressed in *Arabidopsis*, they possess distinct molecular properties and functions in floral organ development, with *PlacAGL6a* uniquely capable of forming homodimers and interacting with C- and D-class MADS-box proteins.

Sisi Zhang, Yalin Tian, Xinggu Lin, Linxia Zhang, Jie Jiang, Guofeng Liu2026-07-01
🧬 biology

Targeting LSD1 inhibits gastric cancer by reprogramming macrophages and restoring T-cell response

This study demonstrates that targeting lysine-specific demethylase 1 (LSD1) with a novel quinoline-based inhibitor, KL-1, effectively suppresses gastric cancer growth by reprogramming macrophages toward an anti-tumor M1 phenotype and restoring functional CD8⁺ T-cell responses, thereby highlighting LSD1 as a promising epigenetic target for immune reprogramming in gastric cancer.

Yi-Chao Zheng, Jingru Pang, Yu Zhang, Haoyi Zhu, Dan-Dan Shen, Bo Wang, Yan Li, Guo-Liang Lu, Ning Wang, Zheng-Hong Yang (…)2026-07-01
🧬 biology

Integrated GWAS and linkage mapping in a multi-parent population prioritizes candidate genes for kernel number per row in maize

By integrating GWAS and linkage mapping in a multi-parent maize population, this study identifies four candidate genes (ZmNMD3, ZmPAPS1, ZmNAC70, and ZmF-box1) controlling kernel number per row, highlighting the value of temperate non-Reid germplasm for future precision breeding.

Yuxiang Luo, Fuyan Jiang, Haoran Lyu, Ranjan K. Shaw, Xingfu Yin, Guohong Wang, Xingming Fan2026-07-01
🧬 biology

Multitechnique characterisation of gut microbiota dynamics in piglets supplemented with Limosilactobacillus reuteri DSPV002C

This exploratory study found that supplementing weaned piglets with *Limosilactobacillus reuteri* DSPV002C led to the strain's persistence and temporal shifts in gut microbial composition, though significant differences in overall diversity or predicted metabolic pathways were not observed, likely due to the small sample size.

Jorge Alberto Zimmermann, Constanza Stoppani, Florencia Aylen Lencina, Nestor Denis Portela, Maria Julia Ruiz, Luis Manu (…)2026-07-01