3881 papers
This study identifies OAS1 as a pan-cancer prognostic and immune biomarker that is upregulated in cervical cancer, where it drives malignant migration and invasion by increasing reactive oxygen species levels, highlighting its potential as a therapeutic target.
Using translaminar recordings in macaque V1 and V4, this study demonstrates that local field potential traveling waves reflect spatiotemporally structured excitatory synaptic inputs whose speed predicts population spiking dynamics, while the multi-unit activity envelope represents the leaky integration of these inputs.
This study reveals that the metabolic enzyme TIGAR regulates CD4+ T-cell differentiation and intestinal inflammation by coordinating glutamine and polyol metabolism, specifically through the suppression of aldose reductase, thereby identifying the polyol pathway as a novel therapeutic target for immune-mediated diseases.
This study elucidates that the enhanced natamycin production in the ARTP-induced *Streptomyces gilvosporeus* 717 mutant is driven primarily by regulatory-region mutations and stage-specific transcriptional reprogramming of transport, metabolic, and biosynthetic pathways, rather than extensive coding-sequence alterations.
This study demonstrates that leiomodin 1 deficiency in human smooth muscle cells promotes lipid accumulation and disrupts coordinated gene regulatory programs in response to oxidized LDL by redirecting transcriptional responses along an orthogonal axis and altering key transcription factor networks, thereby providing a mechanistic basis for its anti-atherogenic role.
By integrating species-specific climate change vulnerability with both taxonomic and genetic diversity data, this study demonstrates that incorporating intraspecific genetic variation into conservation planning for Pyrenean Trichoptera identifies more spatially diverse and robust priority areas than taxonomic approaches alone, thereby better safeguarding vulnerable high-mountain freshwater ecosystems.
This paper describes two new ant species, *Lasius castor* and *L. pollux*, which represent an ongoing evolutionary transition from temporary social parasitism to a stable, mixed-nest association with closely related *Chthonolasius* hosts, characterized by unique morphological adaptations and a distinct behavioral shift away from typical parasitic colony foundation.
This study demonstrates that the circular RNA circ-SOX5 promotes hepatocellular carcinoma progression and remodels the tumor immune microenvironment by acting as a competitive endogenous RNA to sponge miR-1294, thereby upregulating downstream target genes that drive proliferation and immune evasion.
This study identifies the Mtor–Eif4ebp1–Eif4e1c translational control axis as a critical intrinsic mechanism that silences oncogenes to limit RAS-driven leukemogenesis, demonstrating that pharmacological inhibition of Mtor with rapamycin effectively suppresses neutrophil expansion in a zebrafish myeloid leukemia model.
This study identifies various *Benedenia* and *Zeuxapta* monogeneans infecting *Seriola* spp. across the Pacific using morphological and molecular analyses, leading to the description of a new species, *Benedenia whittingtoni*, from Australian *Seriola hippos*, while clarifying the distribution and distinguishing features of other regional species.