3881 papers
This study validates a digital PCR (dPCR) assay to demonstrate that TCR-engineered regulatory T cells exhibit superior lentiviral integration and transgene expression compared to conventional T cells, while establishing dPCR as a precise tool for both manufacturing control and long-term in vivo monitoring of these therapies.
The study demonstrates that the yeast *Papiliotrema terrestris* PT22AV contributes to soil suppressiveness against fungal pathogens by persisting in the rhizosphere and producing antifungal volatile compounds through branched-chain amino acid catabolism via the Ehrlich pathway.
This study establishes a novel probe-based spatial transcriptomics workflow compatible with FFPE tissue that enables the simultaneous detection of intratumoral bacterial communities and host gene expression, revealing spatially resolved host-microbiome interactions in colorectal cancer.
This study demonstrates that while 445-nm low-level laser irradiation preserves the viability and proliferation of stem cells from human exfoliated deciduous teeth (SHED), 660-nm irradiation significantly reduces these parameters after 72 hours, highlighting the critical importance of wavelength and energy density optimization for regenerative dentistry applications.
This study utilizes single-cell and bulk transcriptomic analyses to demonstrate that neoadjuvant therapy in locally advanced rectal cancer primarily induces patient-specific transcriptional state remodeling within malignant cells rather than clonal replacement, with Program2 showing consistent longitudinal reduction post-treatment.
This study demonstrates that direct regression of empirical Bayes-corrected hit rates and multi-label aggregation strategies outperform traditional threshold-specific binary classification for predicting frequent hitters in high-throughput screening, offering a more robust, cutoff-agnostic approach that improves early enrichment and global ranking.
Sargassum horneri polyphenols (SHPP) exert neuroprotective effects against rotenone-induced SH-SY5Y cell injury by restoring mitochondrial function, alleviating oxidative stress, inhibiting mitochondria-mediated apoptosis, and reducing neuroinflammation through the precise regulation of core genes.
This study identified and experimentally validated a six-gene lactylation-related prognostic signature (KIF23, TOP2A, HSPD1, DTYMK, CAV3, and CYP27A1) that effectively stratifies lung adenocarcinoma patients by risk and stemness, revealing potential therapeutic targets and biological mechanisms.
This study presents a hybrid-inlet pinched flow fractionation microfluidic chip that overcomes particle retention and focusing instability to achieve highly efficient, reproducible, and label-free size-based separation of microalgae with sorting rates exceeding 90% and purities above 92%.
This study characterizes the anatomical distribution and genetic profile of epicardial adipose tissue (EAT) in hyperglucagonemic αRhebTg mice, establishing them as a novel experimental model for investigating the effects of GLP-1 triple agonists on this metabolically active fat depot relevant to cardiovascular disease.