3881 papers
EpiPPI is a novel, biologically inspired algorithm that leverages epigenetic attention mechanisms and condition-specific gene expression data to infer genome-scale, condition-specific directed protein–protein interaction networks, significantly outperforming existing topology-based methods in accuracy and biological relevance.
This study identifies seven barley BAG genes, characterizes their evolutionary relationships and promoter motifs, and reveals their distinct tissue-specific expression patterns under drought and heat stresses, providing a foundation for future efforts to enhance crop abiotic stress tolerance.
This study demonstrates that in ovariectomized mice, chemogenetic inhibition of oxytocin neurons in the paraventricular nucleus and their projections to the lateral septum alleviates social recognition memory deficits by counteracting the detrimental effects of estrogen withdrawal.
This study of 231 children and adolescents reveals that while gut microbiota composition differs significantly between individuals with autism spectrum disorder and typically developing controls, the specific abundance of *Enterococcus* is notably associated with structural variations in the cingulate cortex, suggesting a potential gut–brain mechanism underlying autistic symptoms.
Using diffusion MRI-based connectivity parcellation, this study reveals that patients with Obsessive Compulsive Disorder exhibit a significant shift toward striosome-like structural volume and connectivity, particularly in the bilateral rostral caudate and putamen, suggesting that altered organization of striatal compartments underpins the disorder's pathophysiology.
This study demonstrates that chronic intra-hypothalamic infusion of 2-arachidonoylglycerol (2-AG) in rats is sufficient to drive diet-dependent obesity, metabolic dysfunction, and peripheral tissue remodeling, thereby establishing sustained central endocannabinoid signaling as a key mechanistic link in the pathogenesis of obesity.
This study demonstrates that Shank3 insufficiency leads to age-dependent mitochondrial dysfunction specifically within dendritic and synaptic compartments, characterized by morphological and dynamic alterations that impair metabolic processes like translation and autophagy, thereby contributing to the synaptic deficits observed in Phelan-McDermid Syndrome.
This study presents a green and scalable fusion protein strategy using *Pichia pastoris* to achieve high-yield production of DOPA-modified mussel adhesive protein Pvfp-5P, which demonstrates superior wound healing promotion, versatile surface adhesion, and exceptional flexibility for biomedical applications.
This study documents the diversity of nine sponge specimens representing eight genera across six orders found in mangrove habitats at Tampora Beach, East Java, Indonesia, thereby addressing the significant data gap regarding mangrove-associated sponge taxonomy and distribution in the region.
This study demonstrates that purified full-length TDP-43, when infused into the rat motor cortex, propagates toxicity along the corticospinal axis to the spinal cord and skeletal muscle, causing mitochondrial dysfunction, neurodegeneration, and behavioral deficits, thereby establishing a non-transgenic model of brain-to-periphery disease spread in ALS.