🧬 biology

Behavioral Clustering and Resting-State EEG Signatures of Transdiagnostic Neurodevelopmental Profiles

This study demonstrates that data-driven, transdiagnostic behavioral clusters in children with neurodevelopmental disorders are distinctively associated with specific resting-state EEG signatures, suggesting that dimensional symptom profiles offer a more neurophysiologically valid characterization of heterogeneity than traditional diagnostic labels.

Emmanuelle Coutu-Nadeau, Vardan Arutiunian, Charles-Olivier Martin, Valérie K. Fontaine, Anne-Marie Bélanger, Khadije Ji (…)2026-08-26
🧬 biology

Beyond the large mother tree: a multi-approach modeling framework reveals the predominance role of site conditions on Parkia biglobosa seedling growth, with a maternal effect limited to germination

This study employs a multi-approach modeling framework to demonstrate that while site conditions are the primary driver of *Parkia biglobosa* seedling growth, a statistically confirmed maternal effect exists but is strictly limited to the germination stage via seed mass, suggesting that conservation efforts should prioritize provenance diversity over selecting the largest seed trees.

Beda Innocent Adji2026-08-26
🧬 biology

Individual-specific network inference reveals heterogeneous responses to chronic restraint stress and voluntary exercise in mice

This study utilizes a machine learning-based Bioreaction-Variation Network (BVN) model to demonstrate that individual-specific differences in stress susceptibility, resilience, and exercise responsiveness in mice are characterized by distinct complexities and organizational patterns in their inferred molecular and physiological networks.

Kazuhiro Shibata, Fuminori Kawano2026-08-26
🧬 biology

Evolutionary stability of ordered bargaining signals under payoff inequality

This paper demonstrates that in a population negotiating for unequal roles, an evolutionarily stable convention emerges where individuals adopt ordered bargaining signals that concentrate on firmer displays to secure higher payoffs, thereby improving coordination efficiency over non-signaling strategies while maintaining resistance against non-participating mutants under specific probability conditions.

Masanori Takano, Takaya Arita2026-08-26
🧬 biology

Comparison of Systemic and Mucosal Synchronous Immunization with Replicating Single-cycle Adenoviruses and SOSIP Protein HIV-1 Vaccines

This study demonstrates that in rhesus macaques, mucosal (specifically intravaginal) immunization with a combination of replicating single-cycle adenovirus and SOSIP protein vaccines provided superior protection against SHIV challenge compared to systemic intramuscular or intranasal routes, highlighting the potential of targeting the mucosal portal of infection for HIV vaccine development.

Michael Barry, Haley Mudrick, Mary Barry, Pramod Nehete, Bharti Nehete, Francois Villinger, Kathryn Shelton, Guang Yang (…)2026-08-26
🧬 biology

Gut bacterial supernatants modulate neuronal survival and neuron–glia morphology in a hippocampal culture model of Parkinson’s disease

This study demonstrates that supernatants from diverse gut bacterial strains exert distinct, cell type-specific effects on neuronal survival and glial morphology in an in vitro model of Parkinson's disease, partially ameliorating α-synuclein-induced toxicity through complex interactions that cannot be attributed to a single metabolite.

Philip A. Hoffmann, Jennifer C. Martin, Ana Sofia Evora, François Brillet, Karen P. Scott, Bettina Platt2026-08-26
🧬 biology

Non-pathogenic Oomycetes as an untapped source of β-glucan: yield, structure, and bioactivity across Pythium and Phytopythium isolates from Thailand

This study identifies non-pathogenic Oomycetes from Thailand as a previously untapped, high-yield source of bioactive β-glucans, demonstrating that specific isolates like *Pythium catenulatum* CHS-10 can produce yields exceeding commercial references while exhibiting conserved structural features and promising antimicrobial, antioxidant, and plant-defense-inducing properties.

N. Maiprom, R. Saelee, P. Koohakan2026-08-26