q-bio papers | Gist.Science

Data-Driven Change-Point SEIR Modeling of the 2025 COVID-19 Epidemic Wave in China: Model Comparison, Robustness Analysis, and Residual Diagnostics

This study demonstrates that a data-driven piecewise SEIR model with a structural change point on May 24, 2025, significantly outperforms a constant-rate model in describing China's 2025 COVID-19 epidemic wave, revealing a robust transition from transmission expansion to contraction rather than relying on precise biological parameter estimates.

Lilin Xu2026-08-26

🧬 biology

Cross-Validated Neural and Biophysical Models for Pediatric Fingerprint Ridge Breadth Age Estimation with Archaeological Applications

This study establishes a cross-validated neural network model using a dedicated pediatric fingerprint reference from Rhodes to demonstrate that Neolithic clay figurines from Knossos were likely manufactured by children, significantly improving age estimation accuracy over previous adult-calibrated methods.

Niev Bhandare, Kimberlee Moran, Maria Mina, Isabella Perry, Olivia Pozniewski2026-08-26

🧬 biology

Neighbor-Contrastive Heterogeneous Graph Learning for Spatially Coherent Representation of Single-Cell Data

This paper proposes Neighbor-Contrastive Heterogeneous Graph Learning, a method that replaces standard instance-discrimination with spatial-adjacency positives to significantly enhance the spatial coherence and Moran's I of single-cell representations while reducing computational costs, without compromising compactness or silhouette scores.

zheng zhao2026-08-26

🧬 biology

Convergent Chromosomal Integration of a Dual-Carbapenemase Platform Drives the Global ST164 CRAB Pandemic: A Multi-Scale Genomic Epidemiology Study

This multi-scale genomic study reveals that the global pandemic spread of the ST164 carbapenem-resistant *Acinetobacter baumannii* clone is driven by a convergent evolutionary strategy involving the chromosomal integration of a dual-carbapenemase platform (Tn6924 carrying *bla*NDM-1 and Tn2006-like carrying *bla*OXA-23), highlighting that high-risk mobile genetic elements themselves have become the primary threat necessitating a shift in surveillance priorities beyond traditional clone monitoring.

Ren Liu, Tianxin Xiang, Peng Liu, Yang Liu, Yongqin Guo, DanDan Wei, Jiehui Qiu, Chunping Wei, Dejin Pan, Jianglong Shi (…)2026-08-26

🧬 biology

The telomeric factor TIN2 safeguards rDNA integrity and reveals Dyskeratosis Congenita as a combined telomere–rDNA disorder

This study reveals that the telomeric protein TIN2 is essential for maintaining rDNA stability and nucleolar function, demonstrating that Dyskeratosis Congenita is a combined telomere–rDNA disorder driven by PARP1-mediated hyper-PARylation and identifying a potential therapeutic target.

Dorthe Payne-Larsen, Stavroula Boukoura, Kezia Oxe, Ekatarina Dulina, Oliver Quevedo, Huixin Xu, Yonglun Luo, Maria A Bl (…)2026-08-26

🧬 biology

LSD1 Expression is Associated with Immune Exclusion and Hypoxia-Related Transcriptional Programs in Triple-Negative Breast Cancer

This study demonstrates that high LSD1 expression in triple-negative breast cancer drives a poor-prognosis phenotype characterized by hypoxia-related transcriptional programs and immune exclusion through AP-1-mediated mechanisms, suggesting LSD1 as a promising therapeutic target for immune-cold TNBC.

Dong Yeul Lee, Jing Han Hong, Peiyong Guan, Bernett Lee, Stefano Perna, Jianzhou Cui, Chenshi Lin, Jin Miao Chen, Hui Xi (…)2026-08-26

🧬 biology

Spatial transcriptomics reveals coordinated epithelial invasion and stromal remodeling in adenomyosis

This study utilizes high-resolution spatial transcriptomics to reveal that coordinated epithelial invasion and stromal remodeling in adenomyosis are driven by region-specific adhesion programs and mediated by CXCL12–CXCR4 and PDGF/IGF signaling axes at the invasive front.

Wenli Gu, Dan Yang, Lulu Shi, Hui Dong, Caihong Yang2026-08-26

🧬 biology

Preferential sharing of virus populations between mothers and infants in early life

This study reveals that while viral sharing between mothers and infants is often transient, a distinct subset of viruses—particularly persistent Microviricetes and transient Anelloviridae—is preferentially and non-randomly transmitted, undergoing stronger positive selection to shape the infant's early virome.

Revathy Krishnamurthy, Ryan Cook, Alise Ponsero, Leon Mijic, Sumeet Tiwari, Judit Talas, Xena Dyball, Hannah Pye, Andrea (…)2026-08-26

🧬 biology

Alkaloid-Rich Extracts from Ocimum gratissimum and Zanthoxylum zanthoxyloides as Potential Antibiotic Adjuvants Against Resistant Bacterial Pathogens

This study demonstrates that alkaloid-rich extracts from *Ocimum gratissimum* and *Zanthoxylum zanthoxyloides* exhibit antibacterial activity and effectively enhance tetracycline efficacy against resistant pathogens, offering a promising plant-based strategy to combat antimicrobial resistance.

Samuel Asiamah Obiri, Denzel Opoku-Kwabi, Francis Ackah Armah, Yaw Opoku-Boahen, Isaac Asiamah2026-08-26

🧬 biology

Structural reductions of Auditory–Temporoparietal Association Cortex in Cannabis Users: Relevance to Neural Systems Implicated in Auditory Hallucinations

Using data from the Human Connectome Project, this study demonstrates that cannabis use is associated with significant cortical thinning in bilateral auditory–temporoparietal regions and increased impulsive decision-making, suggesting that cannabis-induced structural alterations in neural systems critical for auditory processing and multisensory integration may contribute to vulnerability for auditory hallucinations and psychosis.

Miguel Quintanilla, Ihsan M. Salloum, Alan N. Francis2026-08-25

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