🧬 Category

q-bio

3881 papers

🧬 biology

Loss of endothelial cell FAK represses cisplatin-induced vascular senescence in distal niches to reduce lung metastatic burden

This study demonstrates that endothelial cell focal adhesion kinase (FAK) is essential for cisplatin-induced vascular senescence and stress responses in the lung, which facilitate tumor cell adhesion and metastatic seeding, suggesting that targeting endothelial FAK could reduce lung metastasis in non-small cell lung cancer patients undergoing platinum-based chemotherapy.

Madeleine Benguigui, Abby Lockwood, Rochani Rajendram, Turkan Gizer, Edward Carter, Eleni Maniati, Pedro Casado, Vinothi (…)2026-08-25
🧬 biology

A Proteomic Atlas of Human Milk: Uncovering Milk Functional Components

This study constructs a unified, queryable human milk proteome atlas through large-scale meta-analysis and machine learning-based network reconstruction, revealing functional modules and regulatory architectures that advance the systems-level understanding of milk's role in neonatal health and development.

Marco Agostino Deriu, Harry Zaverdas, Syed Taimoor Hussain Shah, Filip Stojceski, Konstantinos Panagiotopoulos, Konstant (…)2026-08-25
🧬 biology

Pro/Ala/Ser (PAS) peptides as an alternative to polyethylene glycol (PEG) for the surface shielding of lipid nanoparticles (LNPs) carrying therapeutic mRNA

This study demonstrates that Pro/Ala/Ser (PAS) peptides can effectively replace polyethylene glycol (PEG) as a surface-shielding component in lipid nanoparticles for mRNA delivery, achieving comparable physicochemical properties and transfection efficiency while offering a biodegradable alternative that avoids anti-PEG immune responses.

Cihan Makbul, Lars Friedrich, Uli Binder, Arne Skerra2026-08-25
🧬 biology

Efficient generation of human oligodendrocyte grafts that restore myelin in adult human brain tissue

This study presents a rapid and efficient method for generating pure, functional human oligodendrocyte grafts from lt-NES cells via SOX10 and OLIG2 induction, demonstrating their ability to survive and remyelinate adult human brain tissue ex vivo as a significant step toward clinical therapy for demyelinating disorders.

Raquel Martinez-Curiel, Oleg Tsupykov, Paula Rincón-Cerrada, Anna-Maissoun Al-Khani, Yogita Sharma, David Martín-Hernánd (…)2026-08-25
🧬 biology

Identification and sex-specific expression analysis of putative sex determining and sexual differentiating genes in the invasive mosquito species Aedes koreicus and Aedes japonicus (Diptera: Culicidae)

This study provides the first molecular characterization of the sex-determination genes *dsx*, *fru*, and *Nix* in the invasive mosquito species *Aedes koreicus* and *Aedes japonicus*, revealing their conserved genomic architecture, sex-specific splicing patterns, and tissue-dependent expression to establish critical targets for novel vector control strategies.

Marianna Varone, Paola Di Lillo, Francesca Lucibelli, Gennaro Volpe, Sara Epis, Paolo Gabrieli, Fabrizio Montarsi, Guido (…)2026-08-25
🧬 biology

Shallow differentiation in genetic structure, morphology and fecundity between populations of two Acropora species on opposite coasts of Peninsular Malaysia

An integrative analysis of genetic, morphological, and reproductive data reveals only shallow intra-specific differentiation between geographically separated populations of *Acropora bifurcata* and *Acropora intermedia* on opposite coasts of Peninsular Malaysia, indicating they remain the same species despite the land barrier.

Alexandra Jordan, Evelyn Jensen, Theresa Rueger, Chun Hong Tan, Li Keat Lee, Po Teen Lim, James Guest2026-08-25
🧬 biology

Cadaver anal-swab metagenomes reveal host-structured and preservation-dependent postmortem microbial ecology

This study analyzes shotgun metagenomics of cadaver anal swabs to demonstrate that postmortem microbial communities retain host-specific signatures and exhibit localized, preservation-dependent signals for early postmortem interval estimation, though bacterial composition alone does not outperform metadata-based predictions.

Changzhe Li, Qian Zhang, Han Zhang, Jingyan Ji, Shunyi Tian, Meiqing Yang, Zhengyang Song, Feiyue Wang, Jiang Huang2026-08-25
🧬 biology

Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer’s disease

This study demonstrates that reduced static functional connectivity across large-scale brain networks is associated with accelerated longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer's disease, whereas time-varying connectivity shows no such relationship.

Mohammadali Javanray, Jonathan Gallego-Rudolf, Yara Yakoub, Ting Qiu, Frederic St-Onge, Jordana Remz, Jean-Paul Soucy, B (…)2026-08-25
🧬 biology

Structural analysis of monomeric RNA-dependent polymerases revamped

This study utilizes pairwise structural comparisons of experimentally determined and predicted RNA-dependent polymerases to construct phylogenetic trees that validate the classification of several viral phyla while challenging the monophyly of Lenarviricota and Duplornaviricota, thereby demonstrating the value of structure-based phylogenies for resolving deep evolutionary relationships in RNA viruses.

Rodrigo Jácome, José Alberto Campillo-Balderas, Adrián Cruz-González, Arturo Becerra, Antonio Lazcano2026-08-25
🧬 biology

Organic mineralization modification enhances biomineralization efficiency of Hepatitis E virus-like particles for development of room-temperature-stable quality control tools in food safety detection

This study demonstrates that biomimetic calcium phosphate mineralization significantly enhances the thermostability of Hepatitis E virus-like particles, enabling the development of cold chain-independent quality control tools for food safety detection.

Hui Li, Zhimei Zhu, Yixin Zhang, Mengying Li, Jiaqi Li, Haochun Zhang, Xingliang Sha, Shuang Li, Yang Li, Mingxiao Ma, Z (…)2026-08-25