3881 papers
This study employs an integrative computational framework to identify four critical conserved motifs within the ABCA4 extracytoplasmic domain 2, demonstrating that variants of uncertain significance disrupting these motifs are thermodynamically destabilizing and providing a prioritized list for reclassification to improve genetic diagnosis of Stargardt disease.
This study demonstrates that native Arabic listeners exhibit a semantic–syntactic resource trade-off when processing spoken discourse, characterized by behavioral advantages and enhanced semantic integration (larger N400) for information-rich content versus increased syntactic reanalysis (larger P600) and constrained semantic processing for rhetorically complex texts.
This study demonstrates that spaceflight induces a conserved ancestral stress response across three enteric bacteria while uniquely triggering a coordinated shutdown of virulence and host-colonization programs in *Salmonella enterica*, prioritizing survival over infection in the space environment.
A global genomic analysis of nearly 80,000 *Salmonella* Enteritidis genomes reveals that the emergence of ciprofloxacin-decreased susceptibility strains in the United States is not driven by specific gene content or the GyrA(D87Y) mutation alone, as this phenomenon has not been observed in non-USA countries and involves complex genomic variations requiring further investigation.
This study sequenced and analyzed the complete chloroplast genomes of 12 *Papaver nudicaule* genotypes from diverse geographical locations to characterize intraspecific genetic variations, including SNPs, indels, SSRs, and inversions, thereby providing valuable genetic resources for the species' conservation and improvement.
This study demonstrates that brewer's spent grain can be effectively valorized as a low-cost substrate for the optimized production of a stable and catalytically efficient extracellular protease by *Yarrowia lipolytica*, offering a sustainable waste-to-value strategy for the circular bioeconomy.
In a study of Big Sarasota Bay, researchers found that mullet jumping frequency is best predicted by a combination of low dissolved oxygen and calm wind speeds, supporting and extending Hoese's internal diving bell hypothesis by demonstrating that wind-driven mixing influences when oxygen-related jumping occurs.
The paper introduces SyndromeKGNM, a novel framework that integrates knowledge graph completion with network medicine to systematically predict and validate multidimensional biomarkers for Traditional Chinese Medicine syndromes, successfully identifying key genes and pathways associated with coronary heart disease with phlegm and blood stasis syndrome.
This EEG/ERP study identifies a novel "Social Stroop" effect in Ultimatum Games, demonstrating that conflicts between an agent's established reputation and their actual offers trigger specific neural signatures in the anterior cingulate cortex and lead to measurable behavioral interference.
Using spatial transcriptomics, this study identifies a distinct "cancer-like" endometriosis subtype characterized by oncogenic signaling and an immunosuppressive microenvironment, providing a molecular framework for understanding its progression to endometriosis-associated ovarian cancer.