1754 papers
This study reveals that *Toxoplasma gondii* infection impairs maternal-fetal tolerance and causes adverse pregnancy outcomes by suppressing the pSTAT3/KLF6 axis, which downregulates LILRB4 on decidual macrophages and disrupts the IDO/iNOS immunoregulatory balance.
This proof-of-concept machine learning study demonstrates that simulated circulating cell-free DNA methylation and miRNA profiles can achieve high accuracy in distinguishing cancer-associated from healthy molecular states, while explicitly emphasizing that these computational results do not validate operational forensic applications and require extensive wet-lab validation and ethical safeguards before any investigative use.
This study identifies DDI2 as a key regulator of autophagy impairment in diabetic peripheral neuropathy through proteomic and transcriptomic analyses of db/db mouse sciatic nerves and RSC96 cells, proposing a comprehensive therapeutic strategy involving the natural compounds fraxetin and cytisine, as well as ATF3 overexpression, to restore autophagic flux and reverse metabolic dysregulation.
This study demonstrates that the impact of visual field of view on vection and motion sickness in virtual reality depends on the spatial reference frame and individual susceptibility, revealing that gravity-referenced framing effectively mitigates symptoms specifically for highly vection-sensitive users.
This study characterizes two *AGL6* homologs in London plane tree (*Platanus acerifolia*), revealing that while both genes share similar expression patterns and promote precocious flowering when overexpressed in *Arabidopsis*, they possess distinct molecular properties and functions in floral organ development, with *PlacAGL6a* uniquely capable of forming homodimers and interacting with C- and D-class MADS-box proteins.
This study demonstrates that targeting lysine-specific demethylase 1 (LSD1) with a novel quinoline-based inhibitor, KL-1, effectively suppresses gastric cancer growth by reprogramming macrophages toward an anti-tumor M1 phenotype and restoring functional CD8⁺ T-cell responses, thereby highlighting LSD1 as a promising epigenetic target for immune reprogramming in gastric cancer.
By integrating GWAS and linkage mapping in a multi-parent maize population, this study identifies four candidate genes (ZmNMD3, ZmPAPS1, ZmNAC70, and ZmF-box1) controlling kernel number per row, highlighting the value of temperate non-Reid germplasm for future precision breeding.
This exploratory study found that supplementing weaned piglets with *Limosilactobacillus reuteri* DSPV002C led to the strain's persistence and temporal shifts in gut microbial composition, though significant differences in overall diversity or predicted metabolic pathways were not observed, likely due to the small sample size.
This study demonstrates that free-ranging wild boars in a Mediterranean ecosystem exhibit significantly elevated circulating IL-6 concentrations compared to intensively reared domestic pigs, identifying IL-6 as a robust immune marker reflecting the distinct inflammatory tone shaped by ecological conditions at the wildlife–livestock interface.
This study demonstrates that while resolving cognitive conflict in 2D Spatial Stroop tasks reliably triggers transient reductions in force moment variability as a sign of shared processing capacity, the specific body axis affected does not strictly align with the direction of manual decision-making, suggesting that cognitive-balance interference is shaped by broader sensorimotor factors like attention shifts rather than just the decision frame of reference.