3881 papers
This study demonstrates that while maternal distress during middle childhood predicts adolescent depressive symptoms during the pandemic, it does so through a moderating interaction with specific cortico-limbic connectivity patterns in the amygdala–hippocampus complex rather than through a mediating mechanism.
This study demonstrates that 4-methylcatechol (4MC) attenuates osteoarthritis progression by preserving GPX4 stability and inhibiting its LAMP2A-dependent lysosomal degradation, thereby preventing ferroptotic chondrocyte injury.
This study identifies crustose coralline algae diversity in southeast Florida and finds that while tile preconditioning significantly enhances coral larval settlement, only the species *Boreolithothamnion* sp. induced settlement in one coral species, suggesting that a lack of effective settlement-inducing algae and the presence of overgrowth-prone Peyssonneliales may contribute to reduced reef recruitment in this degraded region.
The MIVAS 3 study demonstrates that higher levels of moderate-to-vigorous physical activity in Spanish adults are significantly associated with increased gut microbiota diversity and distinct compositional changes, even after adjusting for key confounders like diet and BMI.
This study integrates transcontinental population genomics and functional validation to reveal that divergent evolutionary trajectories in grapevine cold adaptation are driven by winter thermal regimes, specifically through a cis-regulatory mechanism where *vvi-miR169g* negatively regulates cold tolerance by cleaving *NF-YA* transcripts.
This study characterizes the molecular, phenotypic, and genomic profiles of genetically diverse UPEC/EAEC hybrid *Escherichia coli* strains isolated from urinary tract infections in Northeastern Brazil, revealing their widespread circulation, heterogeneous virulence traits, and complex evolutionary trajectories.
This study presents the first genomic characterization of a multidrug-resistant and virulent *Shigella sonnei* strain isolated from poultry in Bangladesh, revealing a high potential for horizontal gene transfer of resistance genes and underscoring the urgent need for a One Health approach to monitor antimicrobial resistance at the human-animal-environment interface.
This study characterizes Parrot bornavirus-4 (PaBV-4) replication in vitro, demonstrating that its host range is primarily determined by cellular permissivity rather than rapid viral adaptation, and revealing strong interference between PaBV-4 and related orthobornaviruses during infection.
This study identifies ATF2 as a critical driver of anti-PD-1 resistance in hepatocellular carcinoma by recruiting M2-like macrophages through a KAT3A-dependent H3K18 lactylation mechanism that enhances CCL2 transcription, thereby establishing a novel therapeutic axis for overcoming immunotherapy failure.
This study evaluates the performance of Gaussian quasi-maximum likelihood, sparse polynomial regression, heteroscedastic neural networks, and a hybrid mechanistic-neural model for estimating stochastic harvesting dynamics with weak Allee effects, finding that while quasi-maximum likelihood is most accurate and efficient under correct model specification, all methods struggle to estimate the weak Allee parameter from sparse low-biomass data, leading to divergent risk assessments for fisheries management as fishing pressure approaches persistence boundaries.