🧬 Category

q-bio

1754 papers

🧬 biology

Diversification of the Corophiida amphipod silk-spinning systems

This study presents the first extensive comparative analysis of silk-spinning systems in 40 corophiidan amphipod species, revealing a conserved ancestral framework alongside multiple independent evolutionary origins of modified structures that co-evolved with strong attachment silk, thereby establishing these crustaceans as a critical model for understanding the diversification of silk-spinning systems beyond insects and spiders.

Siena McKim, Brittany Cummings, Siena Waldman, Antonia Johnstone, Adam Wall, Kevin Kocot, Thomas Turner2026-07-01
🧬 biology

Lethal and sublethal effects of three mosquito larvicides on the endangered Romer’s Tree Frog (Liuixalus romeri): implications for urban mosquito control

This study demonstrates that while larvicidal oil poses a severe lethal and sublethal threat to the endangered Romer's Tree Frog, Bacillus thuringiensis israelensis (Bti) and temephos are safer alternatives for urban mosquito control, highlighting the critical need to evaluate both acute and prolonged exposure effects in ecological risk assessments.

Yik-Hei Sung, Hiu Nam Kong, Alex Hua Bing Liu, Hiu Ching Yuen, Franco Ka Wah Leung, Amy Wing Lam Fok, Tin Yan Hui, Micha (…)2026-07-01
🧬 biology

Enhanced extracellular invertase production in Bacillus subtilis by boosting synthesis and secretion in a suitable chassis cell

This study reports the first successful expression of the raffinose-hydrolyzing enzyme InvDz13 in *Bacillus subtilis*, achieving a record-high extracellular activity of 568.86 U/mL through a multidimensional combinatorial strategy involving chassis engineering, promoter optimization, signal peptide screening, and secretion pathway regulation.

Dongbang Yao, Yuanyuan chen, Longwei Que, Jiaru Qi, Fangmin Gu, Wei Fang, Zemin Fang, Juanjuan Liu, Yazhong Xiao2026-07-01
🧬 biology

Functional analysis of grapevine phosphoenolpyruvate carboxylase kinases (VvPPCKs) reveals a new role as regulators of the defence response and induction of resveratrol production in grapevine cells under elicitation

This study demonstrates that in grapevine cells, the overexpression of phosphoenolpyruvate carboxylase kinases (VvPPCKs) enhances PEPC activity while negatively regulating the stress-induced biosynthesis of the defense compound resveratrol, whereas silencing these kinases has the opposite effect.

Elías Hurtado-Gaitán, Ascensión Martínez-Márquez, María José Martínez-Esteso, Jaime Alfredo Morante-Carriel, James Hartw (…)2026-07-01
🧬 biology

R1398 is the GTP-𝛾-phosphate sensor that drives the ROC G-domain switching mechanism unique to Parkinson's disease-associated LRRK2

This study identifies the R1398 residue as a critical GTP-γ-phosphate sensor that regulates the conformational switching of the LRRK2 ROC domain, demonstrating that the protective R1398H mutation stabilizes an inactive GDP-bound state by impairing GTP-state stabilization and offering a novel therapeutic strategy for Parkinson's disease targeting the GTPase domain rather than the kinase active site.

Quyen Hoang, Yangshin Park, Chunxiang Wu, Rajnesh Yadav, Kayla Tennessen, Neo Hoang, Cardea Hoang, Xylena Reed, Xiaorong (…)2026-07-01
🧬 biology

Network propagation in bipartite metabolite–reaction graphs for metabolomic data exploration

This study introduces and validates a network propagation framework on a bipartite metabolite–reaction graph that diffuses statistical signals across the metabolic topology to enhance the exploration of partially observed metabolomic data, improve multivariate predictive performance, and facilitate hypothesis generation beyond traditional pathway-based approaches.

Julia Kuligowski, Marta Moreno-Torres, David Pérez-Guaita, Francesc Albert Esteve-Turrillas, Guillermo Quintas2026-07-01
🧬 biology

Integrated metabolomic and proteomic analyses reveal the regulatory mechanism of H-2-168 against Echinococcus granulosus infection in mice

This study employs integrated metabolomic and proteomic analyses to demonstrate that the harmine derivative H-2-168 alleviates *Echinococcus granulosus*-induced hepatic injury in mice by modulating key metabolic pathways, including tryptophan and sphingolipid metabolism, and regulating a complex network of proteins and metabolites involved in inflammation, oxidative stress, and ferroptosis.

Yixueying Ma, Qinwei Xu, Yujie Huang, Jinxin Li, Haoyuan Xu, Huijing Gao, Liang Teng2026-07-01