3881 papers
The authors developed jaxon, a fast and differentiable GPU-native simulator that reveals standard single-fiber models significantly overestimate stimulation selectivity in human peripheral nerves due to large fascicle sizes, a discrepancy that can be corrected by validating designs on full fiber populations.
This meta-analysis of over 1,000 populations across 454 species demonstrates that the genomic inbreeding coefficient (FROH) is a significant predictor of extinction risk, with higher FROH levels correlating with greater threat status, particularly in species exhibiting slow life history traits.
This study of a Chinese cohort demonstrates that in hormone receptor-positive, HER2-negative early-stage breast cancer, the 21-gene recurrence score is primarily driven by molecular pathway activities—specifically the invasion and estrogen group scores—which explain significantly more variance than traditional clinicopathological factors, with histological grade being the sole independent clinical predictor.
This study reveals that male and female LRRK2 G2019S mice exhibit sex- and age-dependent differences in retinal ganglion cell structural degeneration and optic nerve metabolic profiles, with males showing earlier deficits that eventually converge with females to a shared pathological endpoint, offering potential biomarkers for early Parkinson's disease staging.
This laboratory-based experimental study demonstrates that clinical bacterial isolates induce variable but generally dose-dependent increases in interleukin-6 (IL-6) production in an ex vivo whole-blood model, highlighting the influence of bacterial burden on early host inflammatory responses.
This study reveals that elevated branched-chain amino acids metabolism promotes intrahepatic cholangiocarcinoma migration and invasion by activating the PI3K-AKT-mTOR pathway via Bcat1, suggesting that dietary restriction of these amino acids could serve as a precision nutrition therapy to inhibit tumor progression.
This study integrates bulk and single-cell transcriptomic data to identify a specific ECM-remodeling perivascular stromal state that drives osteoclast functional programs and correlates with poor bone metastasis-free survival in breast cancer, highlighting ITGAV as a key mediator for future validation.
This study demonstrates that chronic kidney disease progression is driven by a complex molecular axis characterized by significantly elevated expression of apoptosis-related genes (CASP8, CASP9), immunosuppressive markers (PDCD1, CTLA4), and fibrosis-inducing TGFB3, alongside severe hematological and biochemical abnormalities.
This study presents a proof-of-concept simulation demonstrating that an interpretable machine learning pipeline can reliably predict human Salmonella antimicrobial resistance from simulated poultry antibiotic residues, thereby validating a computational framework for generating One Health hypotheses while emphasizing the need for future validation on real-world linked data.
This study introduces a novel, non-verbal online "Memory Game" and demonstrates that individuals with Fragile X syndrome exhibit significant associative learning deficits driven by impaired initial acquisition rather than accelerated forgetting, a pattern conserved across human and Drosophila models that supports the task's utility as a remote biomarker for clinical trials.