3881 papers
The paper introduces GenomicLLM_v2, a framework utilizing context-guided LLM-based synthetic genotype generation and hybrid SNP prioritization to enhance genomic prediction accuracy in small breeding populations, though its effectiveness varies by dataset and is limited by biological mismatches like heterozygosity differences.
This study demonstrates that the protein tyrosine phosphatase Ptpn20 is essential for maintaining choroid plexus epithelial integrity and amyloid-β homeostasis, as its deficiency disrupts apical structures and accelerates Alzheimer's disease pathology through impaired blood–CSF barrier function.
This study reveals a rapid, inflammation-independent mechanism where lipopolysaccharide (LPS) directly binds to and inactivates insulin via hydrophobic interactions, while high-density lipoprotein (HDL) facilitates the clearance of these complexes through the SR-B1 pathway.
This study combines computational and cell biology approaches to demonstrate that the specific sequence and structure of the Mfd protein dictate its role in bacterial virulence and antibiotic resistance, thereby identifying it as a promising therapeutic target for inhibiting bacterial adaptation.
This study demonstrates that autistic females exhibit preserved higher-order cognition compared to their male counterparts across two independent cohorts, suggesting that this cognitive resilience may underlie the subtler clinical presentations of autism in females and has significant implications for detection and understanding sex differences in the disorder.
This study identifies SORCS2, a human homolog of the yeast vacuolar sorting receptor PEP1, as a genetic modifier that influences Niemann–Pick type C cellular phenotypes, suggesting its potential as a therapeutic target.
This study utilized shotgun metagenomic sequencing of Arctic lamprey gut contents in the Gulf of Ob to identify whitefishes (Coregonus) as their primary prey, demonstrating the method's utility for elucidating regional feeding ecology while highlighting the necessity for curated, location-specific reference databases.
This paper introduces JAX-EP, the first fully differentiable, GPU-accelerated monodomain solver for cardiac electrophysiology that leverages JAX's automatic differentiation to enable rapid, gradient-based parameter inference and digital twin personalization directly from clinical recordings.
This study identifies five quantitative trait loci and associated candidate genes in tomato that govern genetic variation in response to the resistance inducer Belvine® against *Phytophthora infestans*, providing valuable genomic resources for breeding strategies aimed at enhancing plant resistance.
This study demonstrates that calycosin exerts anti-tumor effects in nasopharyngeal carcinoma by inhibiting proliferation and inducing apoptosis, but its efficacy is limited by a compensatory ABCC1-mediated resistance mechanism that can be overcome through ABCC1 silencing to enhance therapeutic outcomes.