1754 papers
This study reveals that the commonly used Neomycin resistance cassette, rather than the Arc/Arg3.1 gene deletion alone, causes severe impairments in maternal and social behaviors in knockout mice by altering ERK signaling and the oxytocin system, thereby necessitating a critical re-evaluation of behavioral phenotypes in animal models retaining this genetic marker.
This study demonstrates that sodium selenite alleviates hyperglycemia-aggravated cerebral ischemia/reperfusion injury by promoting mitochondrial biogenesis through the Selenoprotein H-mediated activation of the AMPK/SIRT1/PGC-1α signaling pathway.
This study demonstrates that integrating floral morphology with nuclear ITS phylogeny provides the most robust framework for resolving species boundaries in Indonesian *Paphiopedilum*, offering critical tools for taxonomy, conservation, and breeding.
This study establishes a robust, scalable, and cost-effective manufacturing platform for recombinant human type I+III collagen in *Pichia pastoris* by combining multi-copy integration, optimized high-density fermentation at 22°C, and an integrated purification process to achieve high yields (10.42 mg/mL) with ≥94.7% purity and ≥90% activity recovery in a 500 L pilot-scale bioreactor.
This study utilized SSR markers to analyze 216 large-leaf tea accessions from four Yunnan regions, revealing abundant genetic diversity primarily within populations and weak regional differentiation driven by extensive gene flow and historical exchange, thereby providing a foundation for future conservation and breeding efforts.
This study demonstrates that the mitochondrial subunit GcQCR7 is essential for *Glomerella cingulata* pathogenicity by maintaining cell wall integrity, energy metabolism, and oxidative stress tolerance, thereby identifying it as a novel target for managing Glomerella leaf spot in apple production.
This study identifies the endoplasmic reticulum as an autonomous mechanosensitive organelle where the transmembrane protein IRE1 directly senses membrane tension to trigger JNK signaling and enhance global protein synthesis, thereby linking mechanical forces to muscle adaptation independently of its canonical unfolded protein response role.
This study challenges the long-held view that Factor XIIIa is the sole transglutaminase responsible for clot stabilization by demonstrating that tissue transglutaminase (TG2) also plays a significant role in reinforcing blood clots and reducing fibrinolysis.
Shotgun-NF is a portable, modular, and reproducible Nextflow pipeline that unifies a comprehensive suite of tools for end-to-end shotgun metagenomics analysis, from raw sequencing data to strain-level comparative insights, while ensuring execution consistency across diverse computing environments through containerization and automated provenance tracking.
This study reports the first investigation in an Iraqi population, finding that the MLH1 −93G/A polymorphism is significantly associated with increased susceptibility to colorectal cancer and correlates with advanced disease progression, including higher histological grades, later TNM stages, and lymph node metastasis.