3881 papers
This study develops a highly sensitive, label-free graphene field-effect transistor (gFET) sensor equipped with a focused post-SELEX aptamer library to enable the specific and rapid quantification of the anti-aging protein Klotho and its critical KL1 domain in human serum.
This study utilizes multi-omic profiling of paired pig liver and kidney xenografts transplanted into a human decedent to reveal distinct, organ-specific innate immune responses and injury patterns despite a shared systemic environment, thereby highlighting the need for organ-specific genetic engineering strategies in xenotransplantation.
This study reveals that UBXN1 facilitates the non-canonical caspase-4 inflammasome by acting as a molecular bridge between unanchored K48/63-linked polyubiquitin chains and caspase-4 to promote its activation and pyroptosis, thereby identifying a critical post-translational regulatory mechanism for bacterial immunity and sepsis.
This study reports the isolation of six proline-based 2,5-diketopiperazines from *Streptomyces canescens* associated with the marine sponge *Haliclona caerulea*, demonstrating their antibacterial activity and potent cytotoxicity against HT29 cells, with molecular docking and simulation confirming compound 5's stable interaction with DHFR and β-tubulin as promising drug leads.
By integrating multi-cohort transcriptomic data with CRISPR-Cas9 dependency maps, this study identifies 17 essential transcriptional drivers in ovarian cancer that regulate critical cell-cycle and chromatin processes, offering a prioritized list of actionable and underexplored therapeutic targets.
A longitudinal analysis of over 15,000 citing sentences reveals that subsequent papers rarely adjust their language to reflect failed replications or mention conflicting evidence, offering readers little indication of whether original findings have been successfully replicated.
This study reveals that terahertz fields regulate Na+ transport through a dynamic hydration-gating mechanism under nanoconfinement, where low-frequency fields enhance ion current by accelerating reversible dehydration-rehydration cycles, while high-frequency fields suppress transport by delaying hydration recovery.
This study documents the repeated nocturnal presence of *Apodemus* mice in forest canopies exceeding 20 meters above ground in Lower Saxony, Germany, challenging the view of these rodents as strictly terrestrial and highlighting the utility of arboreal camera traps for revealing their vertical habitat use.
This study demonstrates that among full-term twins, monochorionic (MCDA) neonates exhibit significantly higher epigenetic gestational age acceleration compared to dichorionic (DCDA) twins, suggesting that the hemodynamic environment associated with placental sharing independently influences biological maturation beyond gestational age.
This study utilizes ¹H NMR-based metabolomics to demonstrate that exposure to silver nanoparticle-embedded water filtration systems induces time- and dose-dependent metabolic disruptions in Persian sturgeon embryos, characterized by shifts in energy metabolism, osmoregulation, and membrane integrity that are more severe with higher silver ion release.