1754 papers
This study demonstrates that the CRISPR/Cas7-11 system serves as a precise, efficient, and low-toxicity RNA knockdown tool capable of inducing specific phenotypic changes in zebrafish embryos and driving differentiation in human embryonic stem cells with minimal off-target effects.
A neutral cannabinoid-rich *Cannabis sativa* L. extract mitigates UVB-induced oxidative stress and partially restores MITF transcriptional suppression in B16-F10 melanoma cells without significantly altering total melanin content, suggesting its potential as a photoprotective agent in dermatological formulations.
This study demonstrates that an edible vaccine developed by expressing conserved PspA B-cell epitopes fused to alpha-zein in transgenic tomato plants successfully protects mice against lethal pneumococcal challenge, highlighting a promising, affordable oral vaccination strategy.
This paper proposes a robust Transformer-based framework for drug–target interaction prediction that integrates bidirectional cross-attention, hybrid local–global semantic aggregation, and stabilized optimization to significantly outperform existing models like MolTrans, particularly in scarce-data and imbalanced scenarios.
This longitudinal study of 471 elderly participants in Qingdao provides the first evidence that a polygenic risk score based on calcium signaling pathway genes is significantly associated with both baseline hearing levels and the accelerated rate of age-related hearing deterioration, particularly in individuals aged 70 and older.
This study expands the genetic landscape of pheochromocytomas, paragangliomas, and pituitary adenomas by identifying pathogenic germline variants in known neuroendocrine genes and describing, for the first time, potential associations with DNA repair and telomere maintenance genes such as TERT and ATM.
This study demonstrates that long-lived mammals have evolved specific codon usage biases—such as depleting hypermutable stopogenic codons and favoring non-optimal codons to slow translation and improve protein folding—to minimize somatic mutations and proteostasis loss, thereby extending lifespan.
This study reveals that a Pinna nobilis Picornavirus (PnPV) infection caused 100% mortality and local extinction of larger fan mussels in the Venice Lagoon's Ottagono Alberoni area by October 2024, while smaller individuals in Coffa Val Grande showed greater tolerance, with mortality rates positively correlating with animal size, viral load, and immune cell depletion.
This study presents the first report of *Colletotrichum viniferum* as an emerging ripe rot pathogen in Indian grapevines, characterizing its phenotypic traits, pathogenicity, and genomic features—including virulence factors and cell wall-degrading enzymes—to establish a quantitative framework for disease management.
This study identified and validated a five-gene cysteine-related prognostic signature (SERPINE1, MATN3, BAALC, SLC7A3, and RNASE1) for gastric cancer, constructing a robust risk model and nomogram that elucidates underlying molecular mechanisms and offers a novel tool for predicting patient survival outcomes.