3881 papers
This study in Dehradun, India, found that female washroom toilet seats are universally contaminated with bacterial pathogens, predominantly *Pseudomonas* spp. and *E. coli*, with the former exhibiting specific antibiotic resistance patterns that underscore the need for improved sanitation and antimicrobial stewardship.
This paper presents a theoretical framework demonstrating that the coupling between the orientational ordering of anisotropic proteins and membrane elasticity drives curvature sensing, protein sorting, and membrane shape remodeling, leading to phenomena such as neck stabilization and tubular protrusions through a balance of curvature matching and elastic forces.
This study demonstrates that macrophages are essential for radiation-induced salivary gland regeneration by interacting with KRT14+ ductal progenitor cells via the CX3CR1-CX3CL1 axis and secreting FGF3 to prime these cells for proliferation and tissue repair.
This study identifies UBE2E3 as a critical E2 ubiquitin-conjugating enzyme that sustains acute myeloid leukemia by maintaining the stability of the BCOR-RING1B axis within the non-canonical PRC1.1 complex, thereby preserving leukemic stemness and disease propagation.
This study compares dictionary-based and large language model (LLM) text analysis methods on 7,303 naturalistic psychedelic reports, finding that while dictionary counts replicate prior U-shaped patterns of mystical vocabulary, LLMs provide a more monotonic and contextually nuanced assessment of mystical experience intensity across key dimensions.
This study utilizes patient-derived brain organoids to demonstrate that distinct classes of DLG4 mutations drive divergent neurodevelopmental mechanisms—ranging from broad developmental disruption to specific gain-of-function isoform effects—and establishes that AAV-mediated gene replacement effectively rescues synaptic and molecular deficits in loss-of-function cases.
This study demonstrates that *Aetoxylon sympetalum* agarwood essential oil exhibits potent, concentration- and time-dependent in vitro anthelmintic activity against adult *Ascaridia galli* comparable to ivermectin, likely through a multi-target mechanism involving the inhibition of bioenergetic and cytoskeletal proteins by its dominant oxygenated sesquiterpenes.
This paper proposes and validates an ensemble perspective where the entropy of a maximum-entropy distribution of Jacobian matrices serves as a robust predictor of ecological community stability, outperforming traditional local contraction measures in identifying states resilient to parameter perturbations and experimental environmental shifts.
This study presents a GPU-accelerated, hybrid three-dimensional agent-based computational framework that successfully simulates multiscale microbial fuel cell dynamics by integrating individual microbial behaviors with spatial transport and electrochemical processes, achieving high predictive accuracy and providing a robust platform for future bioelectrochemical system design.
This study elucidates a multi-omics causal chain in which weaning-induced microbiota dysbiosis and butyrate depletion trigger EGR1-mediated AREG-EGFR autocrine signaling in enterocytes, driving premature three-dimensional reprogramming and barrier collapse in piglets.