3881 papers
This study demonstrates that human disturbances significantly amplify airborne health risks by reshaping microbial and viral communities, increasing antibiotic resistance and virulence factors, and enhancing cross-habitat gene transfer, with these effects varying notably between road dust and settled dust across urban-rural gradients.
This study integrates full-body kinematics with cortical and subthalamic neural recordings in Parkinson's disease patients to demonstrate that specific gait domains, particularly gait variability, are associated with phase-dependent sensorimotor low-gamma power, offering a framework for targeted adaptive neuromodulation.
This study demonstrates that while abiraterone is a more potent CYP17A1 inhibitor, seviteronel exhibits superior selectivity for the 17,20-lyase activity over 17α-hydroxylase due to distinct structural anchoring mechanisms, resulting in different steroidogenic profiles and shared sensitization of prostate cancer cells to ferroptosis.
This study reports the isolation, molecular identification, and optimization of cellulase production from a novel *Pseudomonas aeruginosa* strain derived from potato peel waste, followed by the partial purification and characterization of the 58kDa enzyme, which was successfully applied to improve the surface quality of cotton fabric.
This paper proposes and evaluates a framework for at-home pediatric sleep screening that integrates acoustic snore classification with an engagement-based reliability gate to prevent low-adherence data from generating misleading risk assessments, demonstrating improved data sufficiency in retrospective and simulation studies.
This study in Sana'a, Yemen, reveals that biofilm-producing *Klebsiella pneumoniae* isolates from urinary tract infections are highly prevalent, frequently exhibit extensive or multidrug resistance, and show a strong statistical association between the *fimH* virulence gene and robust biofilm formation.
This study finds no moderate-to-large absolute shift in the mitochondrial chaperonin–import axis (including HSPD1, HSPE1, and TOMM20) in the dorsolateral prefrontal cortex of individuals with autism spectrum disorder, distinguishing it from the previously reported modest down-regulation of broader oxidative-phosphorylation gene modules.
This in silico study reveals that esophageal and colorectal adenocarcinomas divergently hijack the GAS5 locus through distinct splicing mechanisms—EAC utilizes precise spliceosome rewiring to enrich specific snoRNAs for ribosome biogenesis, while CRC employs chaotic macro-skips triggering NMD to destroy the ceRNA sponge and unleash miR-21-mediated oncogenic signaling.
The paper presents Usnica 4.1 GPU, a multiscale Bayesian-calibrated framework that overcomes the prohibitive computational costs of simulating 86 billion neurons on a single consumer GPU by employing efficient approximations, thereby enabling the rapid validation of Alzheimer's disease compounds and the proposal of a safe, long-term therapeutic triple combination.
Through an integrative machine learning pipeline analyzing RNA-seq data, this study identified a reproducible six-gene biomarker signature for Acute Myeloid Leukemia, with SLC25A37, FKBP8, and PHOSPHO1 emerging as the most consistent core genes across multiple cohorts.