1754 papers
A newly isolated, safe gut bacterium, *Niallia circulans* YL01, effectively biodegrades L-homocysteine via remethylation and transsulfuration pathways, offering a promising microbial therapeutic strategy for treating hyperhomocysteinemia.
Early vitamin B12 treatment in SARS-CoV-2-infected hamsters mitigates long COVID-associated hippocampal neuroinflammation and neurodegeneration by preventing weight loss and suppressing CCL11 elevation, with sex-dependent effects on specific cellular alterations.
This study systematically compares four multicellular tumor spheroid fabrication platforms (U-bottom, ultra-low attachment, hanging drop, and droplet microfluidics), revealing that while they differ in fabrication efficiency and structural stability under dynamic conditions, these platform-dependent variations are critical factors to consider for reliable drug screening outcomes.
This study reveals that BHET-hydrolyzing enzymes are widespread in marine environments and function as a crucial downstream component of a community-based pathway for PET plastic degradation, where diverse microbes collaboratively complete the breakdown process through a division of labor.
Green-synthesized zinc oxide nanoparticles derived from *Senna auriculata* flowers exhibit significant antioxidant, antimicrobial, and mitochondria-mediated anticancer activities, demonstrating their potential for biomedical and therapeutic applications.
This paper argues that the Western gut microbiome, despite appearing healthy, possesses a hidden resilience deficit characterized by low functional redundancy and reliance on keystone taxa, making it structurally fragile and prone to abrupt, irreversible shifts when faced with perturbations.
GlyGen is a comprehensive knowledgebase that harmonizes and integrates fragmented glycan, protein, and gene data into a unified, ontology-driven model to facilitate the discovery of novel biological connections and advance glycoscience within the broader biomedical ecosystem.
This study presents a novel graphene oxide–gelatin–calcium integrated Transwell platform that enables non-destructive, bidirectional electrochemical monitoring of oxygen dynamics to spatially resolve the asymmetric progression of epidermal differentiation in keratinocyte cultures.
This study demonstrates that long-term, gene-free photostimulation using a far-red absorbing organic semiconductor (PCPDTBT) effectively promotes the comprehensive maturation of human pluripotent stem cell-derived cardiomyocytes across transcriptional, functional, structural, and metabolic levels without causing phototoxicity, thereby enhancing their utility for disease modeling and therapeutic applications.
This study utilizes untargeted cord blood metabolomics to reveal that neonates with gastroschisis exhibit a distinct metabolic profile characterized by significant alterations in lipid metabolism, including reduced free fatty acids and disrupted bile acid pathways, which may underlie their susceptibility to gastrointestinal complications.