1754 papers
This study demonstrates that in regenerating Atlantic Forest vegetation, early community reorganization is driven by recruitment dynamics and vertical stratification—particularly in the lower stratum—rather than immediate floristic turnover, suggesting that structural changes precede detectable compositional shifts during ecological succession.
This longitudinal multimodal MRI and imaging genetics study demonstrates that both short-term and long-term social media exposure induce distinct functional and structural brain plasticity, respectively, with the magnitude of these neuroimaging changes varying according to habitual usage patterns and individual APOE and BDNF genotypes.
This study reveals that exogenous serotonin enhances the antitumor efficacy of anti-PD-1 therapy by inducing TGM2-mediated serotonylation of STAT1 in CD8+ T cells, which remodels mitochondrial dynamics to suppress fission and promote fusion, thereby boosting T cell function.
This study reveals that cnidocyte diversification across cnidarians is driven by a conserved core gene regulatory network elaborated with extensive lineage-specific transcriptional programs, demonstrating that homologous cell types can share less than 25% transcriptional similarity.
This study introduces a practical AlphaFold 3-based framework for the structural assessment of peptide-HLA class I complexes that corrects common immunoinformatics modeling errors by accurately reproducing key biological features and providing biologically meaningful insights beyond conventional affinity-based predictions.
This study identifies a large-scale supergene, characterized by a 1.75 Mbp inversion and translocation, that governs wing polymorphism in *Myrmecina nipponica* queens and likely evolved within and among *Myrmecina* species to mediate caste determination through transcriptional regulation of nutritional responses.
This study identifies a heterochronic expression pattern of TFAP2β, revealing that while its protein levels normally decline by term in mammalian models, they persist postnatally specifically within the obstructive shelf of coarctation of the aorta, offering a potential mechanistic insight into this congenital heart defect.
This genome-wide association study of 607 athletes of European ancestry failed to identify genome-wide significant genetic variants for anterior cruciate ligament rupture but highlighted several suggestive loci involved in inflammation, cellular stress, and ciliary function that warrant further investigation in larger cohorts.
This study reanalyzes single-cell transcriptomic data from human pancreatic islets to demonstrate that type 2 diabetes-associated signatures are subtle and compartment-specific, with immune-enriched signals like CXCL3 being best detected through donor-aware pseudobulk analysis rather than global or cell-level approaches.
This study demonstrates that attenuated *Salmonella* Typhimurium engineered to express bioactive interleukin-18 exerts potent antitumor effects against colorectal cancer by significantly reducing tumor cell viability and shifting the tumor microenvironment toward a pro-inflammatory, antitumor state.