1754 papers
This study demonstrates that while the CYP6P4-I236M mutation in *Anopheles gambiae* confers strong resistance to pyrethroid and PBO-based nets, it imposes significant fitness costs and reduced efficacy against chlorfenapyr-based nets, suggesting that rotation or mixture strategies with chlorfenapyr could effectively manage resistance.
This study reveals that the bigfin reef squid in the Mediterranean Sea comprises at least two distinct cryptic lineages of Red Sea origin, challenging the traditional view of *Sepioteuthis lessoniana* as a single species and highlighting the complexity of Lessepsian invasions.
This study developed and validated a highly specific and sensitive CRISPR/Cas12a-based detection system capable of accurately discriminating between the two genetically distinct *Plasmodium ovale* species (*P. wallikeri* and *P. curtisi*) in clinical samples, offering a promising tool for improved malaria diagnosis and surveillance.
This study documents the diversity, nesting ecology, and worker-level morphometric structure of stingless bees in Central Cameroon's bimodal forest zone, revealing that *Hypotrigona gribodoi* and *Dactylurina staudingeri* exhibit contrasting, size-structured phenotypic variations and distinct nesting habits while establishing the first locality-resolved baseline to support conservation and meliponiculture.
This study establishes and comprehensively characterizes a biobank of 40 living human kidney tubuloids derived from fresh and cryopreserved adult tissues, demonstrating their structural fidelity, molecular diversity, and compatibility with microfluidic systems to serve as a robust resource for drug screening, disease modeling, and precision medicine.
This study identifies adenylate cyclase 6 (Adcy6) as an evolutionarily conserved, essential regulator within both Schwann cells and neurons that drives timely peripheral nerve development, myelination, and ion channel clustering through cAMP signaling in vertebrates.
This study reports a novel AR c.2319-1G>T variant causing complete androgen insensitivity syndrome via exon 6 skipping, confirming through transcript analysis that canonical splice-site disruptions strongly correlate with this severe phenotype while highlighting limitations in relying solely on in silico prediction tools for non-substitution variants.
This study utilizes molecular docking simulations to demonstrate that while Roscovitine and Pifithrin-α exhibit strong predicted binding affinities to the CDK2 ATP-pocket with distinct interaction profiles, Nutlin-3 shows significantly weaker binding, suggesting Pifithrin-α warrants further investigation as a potential off-target binder within the p53 signaling pathway.
This study demonstrates that while conventional ratio scaling of peak oxygen uptake (VO₂peak) retains significant residual dependence on body mass, regression–residual normalization effectively eliminates this bias, offering a superior alternative to both ratio scaling and conventional allometric modeling for adjusting aerobic capacity across diverse body sizes.
This study demonstrates that trichloroethylene sensitization induces kidney injury in mice by upregulating β2 integrin, which triggers neutrophil activation and the release of neutrophil extracellular traps (NETs) via the PAD4 pathway.