q-bio papers | Gist.Science

Development and validation of pLIN, a permanent lineage-numbering system for tracking antimicrobial resistance plasmids

The paper introduces pLIN, a permanent, hierarchical lineage-numbering system that overcomes the limitations of traditional replicon typing by assigning stable, strain-level identifiers to antimicrobial resistance plasmids based on tetranucleotide composition, thereby enabling robust global surveillance and tracking of high-risk resistance lineages without requiring specialized bioinformatics expertise.

Basil Britto Xavier, Anurag Kumar Bari, Bhanu Sinha, John Rossen2026-08-24

🧬 biology

Butachlor-induced phytotoxicity and oxidative stress in Spirodela polyrhiza

This study demonstrates that butachlor induces concentration-dependent phytotoxicity and oxidative stress in *Spirodela polyrhiza* by disrupting growth, photosynthesis, and primary metabolism, while simultaneously triggering significant antioxidant and osmoprotective responses that ultimately result in severe growth inhibition.

Harshita Mishra, K. Suresh Kumar, Vandana Arya, Swati Mishra, Ashutosh Pathak2026-08-24

🧬 biology

Emotional Context Changes Segment Memory, Predictions Determine Its Strength

This study demonstrates that while emotional context changes drive the segmentation of experience into discrete memories, the magnitude of this segmentation is modulated by the compatibility of moment-to-moment predictions with those upcoming changes.

Ahmet Bağlar, Berna Güler, Eren Günseli2026-08-24

🧬 biology

Cultivation-dependent effects of quorum sensing signals on a lactic acid and chain-elongating bacterium

This study reveals that the effects of quorum sensing signals on lactic acid and chain-elongating bacteria are highly dependent on the specific signal, substrate, and cultivation context, demonstrating that pure-culture responses often fail to predict behavior in microbial consortia relevant to circular biomanufacturing.

Lena Depaz, Anouk Nys, Shanaya Scharloo, Celia Álvarez Fernández, Jana De Bodt, Josefien Van Landuyt, Jo De Vrieze, Ramo (…)2026-08-24

🧬 biology

Parental, Prenatal, and Postnatal Nicotine Exposure Enhances the Induction and Expression of Locomotor Sensitization to Nicotine in Rats

This study demonstrates that combined prenatal and postnatal nicotine exposure in rats significantly enhances locomotor sensitization to nicotine in a dose- and age-dependent manner, suggesting an increased vulnerability to nicotine abuse in offspring.

Susana Barbosa Méndez, Alberto Salazar-Juárez2026-08-24

🧬 biology

Entrenchment in Human Exploration: A Future-Path Model of Early Convergence

This paper introduces a cognitive model of "entrenchment" in human exploration, demonstrating that people prematurely settle on suboptimal options by simulating their own future choices, a mechanism that uniquely explains increased non-greedy behavior with longer horizons and distinguishes itself from standard exploration strategies like UCB or Thompson sampling.

Shinji Nakazato2026-08-24

🧬 biology

Topology-based Physical Reconstruction of Biological Networks

This paper proposes a reproducible, topology-based method that reconstructs the physical spatial coordinates of biological networks by minimizing effective potential energy, thereby transforming topological data from sources like STRING into a metric space suitable for quantitative physical and mathematical analysis.

Iryna Oliynyk2026-08-24

🧬 biology

Bipolar disorder-associated variants in RAB5A disrupt its function in endolysosomal trafficking in fruit fly and mammalian systems

This study demonstrates that specific RAB5A variants associated with bipolar disorder disrupt endolysosomal trafficking and neuronal function in both fruit fly and mammalian models, validating Drosophila as an effective system for assessing the pathogenicity of psychiatric disorder-related genetic variants.

Jimmy Holder, Jonathan Andrews, Basabdatta Adhikari, Michael Wangler, Jill Rosenfeld, Rebekah Townsley, Saurabh Srivasta (…)2026-08-24

🧬 biology

OsEIN2-OsEIL1/2-OsNAP module regulates rice thermotolerance and leaf senescence

This study reveals that the OsEIN2-OsEIL1/2-OsNAP module negatively regulates rice thermotolerance and promotes leaf senescence by directly activating OsNAP expression and repressing the thermotolerance factor OsEIL5, thereby triggering ROS accumulation and cell death under heat stress.

Mingjuan Zhai, Kexin Xue, Yating Chen, Xiaodan Jiang, Yaping Li, Xianzhi Xie, Xiaowu Pan, Haiwen Zhang2026-08-24

🧬 biology

TrypOne: Fluorescence-Based One-Pot CRISPR-LAMP Assay for Point-of-Need Diagnosis of Trypanosomosis

The study introduces TrypOne, a sensitive, specific, and field-deployable one-pot CRISPR-LAMP assay that enables rapid, fluorescence-based detection of active *Trypanosoma brucei* infections with performance comparable to gold-standard PCR, offering a promising tool for One Health surveillance and treatment monitoring.

Andrés Álvarez-Rodríguez, Unhwa Lee, Bo-Kyung Jin, Pieter Thomassen, Adrián Muñoz-Aranzueque, Peter Geldhof, Zeng Li, Be (…)2026-08-24

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