3881 papers
This study demonstrates that 3D tumor spheroid models effectively mimic in vivo necrotic environments to validate the colonization, antibiotic sensitivity, and therapeutic efficacy of anaerobic bacteria like *Clostridium sporogenes*, serving as a crucial intermediate step between in vitro and in vivo cancer research.
This study identifies the uORF-encoded micropeptide TCEA1-45aa as a hypoxia-responsive driver of hepatocellular carcinoma progression that stabilizes ENO1 to enhance glycolysis via an m⁶A–YTHDF3-mediated translational mechanism, revealing a potential therapeutic vulnerability in HCC.
Cyclin A2 overexpression drives replication stress and subsequent chromosome breakage and aneuploidy specifically in p53-deficient cells by forcing premature cell-cycle progression despite impaired DNA replication, thereby potentially accelerating tumor evolution through genome diversification.
This study presents the first genome-wide characterization of simple sequence repeats (SSRs) in coriander and four related Apiaceae species, revealing their distinct distribution patterns, low cross-genus primer transferability, and the utility of newly developed markers for assessing the crop's limited genetic diversity.
This study identifies stable Caveolin-1–EEA1 endosomes as a conserved, clathrin-independent platform in developing neurons that coordinates TGFβ receptor trafficking and signaling during axonal specification and elongation.
This study characterizes the bovine-derived probiotic *Lactiplantibacillus plantarum* HCD07 and demonstrates that while its preventive and therapeutic administration mitigated weight loss in ETEC O8-challenged mice, it did not establish clear mucosal protection or a microbiota-mediated mechanism, indicating a need for further evaluation of its functional endpoints.
This study demonstrates that the ER-resident lipid scramblase TMEM41B physically associates with and co-traffics with activated STING to the Golgi within a permissive early-secretory pathway context, suggesting a broader role in ER-to-Golgi transport rather than STING-specific regulation.
This study establishes a scientific foundation for forensic hand identification by characterizing the three-dimensional morphological diversity of Japanese adult fingertips and nails through principal component analysis and interphalangeal measurements.
This study demonstrates that *Tinospora cordifolia* extract effectively inhibits *Staphylococcus aureus* biofilm formation, identifying the phytocompounds rutaretin and cyclonormammein as potent inhibitors of the AgrA protein with cyclonormammein emerging as a promising drug candidate based on in silico ADMET profiling.
This study demonstrates that hsa_circ_0001944 promotes colorectal cancer progression by acting as a molecular sponge for miR-665 to upregulate IGF2BP1, which subsequently enhances PKM2-mediated glycolysis and tumor growth.