q-bio papers | Gist.Science

Feasibility of RNA Sequencing from Human Skin Microbiopsies in Actinic Keratosis and Basal Cell Carcinoma: A Paired Pilot Comparison with Shave Biopsy

This pilot study demonstrates that minimally invasive skin microbiopsies can generate high-quality, concordant RNA sequencing profiles comparable to conventional shave biopsies for actinic keratosis and basal cell carcinoma, establishing the feasibility of this approach for molecular research while highlighting the need for larger, standardized studies to confirm clinical utility.

Miko Yamada, Vidiya Dev, Tarl Prow2026-06-30

🧬 biology

Deciphering lysosomal autophagy-linked differential gene signatures in Alzheimer’s disease: Multicohort bioinformatics analysis leveraging Gene Expression Omnibus datasets

This multicohort bioinformatics study identifies 44 lysosomal autophagy-linked differentially expressed genes in Alzheimer's disease, highlighting seven pivotal genes that form a robust diagnostic model and suggesting their potential as therapeutic targets through their involvement in autophagy-lysosome pathways and immune cell interactions.

ying Peng2026-06-30

🧬 biology

Effects of Neonatal Tactile Stimulation on Thermal Nociceptive Responses in WAG/Rij Rats

This study demonstrates that early-life tactile stimulation produces long-term, sex-dependent modulation of thermal nociceptive responses in WAG/Rij rats, specifically increasing pain thresholds in males under lower-intensity stimulation without affecting females.

Aymen Balikci, Vildan Keles Guler, Gonul Gurol, Teresa A. May-Benson, Gul Ilbay2026-06-30

🧬 biology

Collateral sensitivity-driven phage cocktail effectively enhances the antibacterial activity against Salmonella enteritidis in chickens

This study demonstrates that a rationally designed triple phage cocktail (PC13, PC11, and PC16) leveraging collateral sensitivity effectively overcomes *Salmonella* resistance and significantly reduces bacterial loads in infected chickens by targeting LPS-altered mutants that become hypersensitive to secondary phages.

Huzhi Sun, Yuanyang Zhao, Yanxin Yan, Guangqin Liu, Qiang Pan, Huiying Ren, Shaowen Li2026-06-30

🧬 biology

Longitudinal RNA Seq analyses reveal the prominent role of Vagococcus in broiler meat spoilage microbiome

This longitudinal study utilizes metatranscriptomics and metabolomics to reveal that *Vagococcus proximus*, alongside known spoilers like *Carnobacterium* species, plays a prominent and previously overlooked active role in the spoilage of broiler meat, particularly at 6°C.

Julia A. Manninen, Elio Nushi, Elina Jääskeläinen, Per Johansson, Johanna Björkroth2026-06-30

🧬 biology

Genome-wide characterization, phylogenetic and expression analysis of ABCG gene subfamily in tomato

This study systematically characterizes 57 tomato ABCG transporters, revealing their evolutionary conservation, stress-responsive regulation, and high expression in floral organs, thereby providing a foundational resource for future functional analysis and breeding applications.

Tianying Zhao, Qihui Wang, Xin Liu, Jing Jiang2026-06-30

🧬 biology

Bioactivity of crude extract from marine-derived Streptomyces avermitilis BIOTECP1C4 against Staphylococcus aureus: antimicrobial, antibiofilm and antivirulence evaluation

This study demonstrates that the ethyl acetate crude extract of the marine-derived *Streptomyces avermitilis* BIOTECP1C4 exhibits moderate antibacterial, antibiofilm, and antivirulence activities against *Staphylococcus aureus* with low toxicity, suggesting its potential as a source of novel antimicrobial agents pending further purification.

Emanuelle Araújo, Elian Chaves Ribeiro, José Silva Domendes, Rafaela Lobato Silva, Maria Clara Miranda Freire, Lívia Cor (…)2026-06-30

🧬 biology

Transcriptomic Characterization of Hypermutated Microsatellite Stable Tumors Reveals Distinct Proliferative and Immune Signatures

This study characterizes hypermutated microsatellite stable tumors across colorectal and endometrial cancers as a distinct biological subgroup defined by shared upregulation of immune and proliferative pathways (such as mTORC1, E2F, and G2M checkpoints) alongside cancer-specific regulatory features, notably involving SLC7A11 and microRNA interactions.

Olesia Kondrateva, Thimona Chrusciel, Maria Anisimova2026-06-30

🧬 biology

The impact of nationwide folic acid fortification on genetic variants associated with conotruncal heart defects

This study utilized genome-wide association analyses to demonstrate that universal folic acid fortification is associated with shifts in the prevalence of specific genetic variants in cardiac developmental pathways, particularly within the DHRS3 and PPARGC1β genes, among children with conotruncal heart defects.

Sarah U. Morton, Enrique Mondragon-Estrada, Rui Qian, Omobola O. Oluwafemi, Kit Sing Au, Hope Northrup, Wendy K. Chung (…)2026-06-30

🧬 biology

Disruption of lysine biosynthesis modulates DNA methylation and developmental programs in Arabidopsis thaliana

This study demonstrates that disrupting lysine biosynthesis via DAPAT deficiency in *Arabidopsis thaliana* reprograms developmental timing and reproductive output by altering DNA methylation patterns and the expression of key flowering regulators, thereby revealing a critical metabolic-epigenetic link between amino acid metabolism and plant growth.

Wagner Araujo, Débora Gouveia, Samantha Flachbart, Wesley Barrios, Philipp Westhoff, Pedro Reis, Alisdair Fernie, Adrian (…)2026-06-29

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