3881 papers
This paper introduces a resource-conserving "share-and-plunder" graph dynamical framework where signed topological interactions directly encode compatibility and incompatibility, enabling the robust and parameter-insensitive sculpting of complex attractor landscapes through a minimal dictionary of structural motifs.
The study demonstrates that a porous poly(vinyl alcohol)-chitosan hybrid scaffold, prepared via a freeze-thaw method, exhibits superior mechanical stability, rapid swelling, intrinsic antibacterial activity, and the ability to support umbilical cord mesenchymal stem cell adhesion and chondrogenic differentiation, making it a promising candidate for cartilage tissue engineering.
This study characterizes hypermethylated promoter regions in canine hemangiosarcoma cell lines, identifies ROBO1 and SLIT/ROBO signaling as key epigenetically regulated pathways, and demonstrates that while decitabine reduces promoter methylation and inhibits growth in some models, its efficacy varies significantly between cell lines, highlighting the molecular heterogeneity of this aggressive tumor.
This study demonstrates that simulated microgravity disrupts mouse peri-implantation morphogenesis by compromising epithelial mechanical homeostasis and polarity, triggering a glucose-dependent metabolic adaptation that partially sustains development.
This study identifies and functionally characterizes a novel heterozygous frameshift mutation (c.405del) in the PAX3 gene within a Chinese family with Waardenburg syndrome type 1, demonstrating that the mutation causes protein truncation, loss of expression, and impaired transcriptional activity.
This multi-omics study demonstrates that somatostatin protects against sepsis-induced intestinal epithelial glycocalyx injury in rats by alleviating mucosal damage, suppressing inflammation, and partially restoring Syndecan-1 levels, likely through the PPAR signaling pathway and the regulation of candidate molecules ALDH1L1 and FGFBP1.
This study analyzes whole-genome sequencing data from 457 koalas to characterize cytokine gene diversity across Australia, identifying specific variants in IL12B and IL17F that correlate with population-level differences in chlamydial disease prevalence and suggesting these genes as key candidates for understanding koala immune resilience.
USP39 protects cardiomyocytes against ischemia-reperfusion injury by regulating the NF-κB/Nrf2 inflammatory-antioxidant axis, as evidenced by increased USP39 expression in MIRI and the exacerbation of cellular damage upon its knockdown.
This study demonstrates that *Klebsiella aerogenes* MB688 is a promising producer of multifunctional lipopeptide biosurfactants and bacteriocins, which were optimized under specific conditions and characterized as having significant antibacterial and antioxidant potentials for applications in food and medicine.
This study identifies a highly efficient *Serratia marcescens* strain that removes 96.18% of antimony via a nonclassical crystallization pathway to form Sb₂O₃, while integrated multi-omics analysis reveals a coordinated metabolic reprogramming strategy that enhances energy generation and oxidative defense while suppressing motility to facilitate biomineralization.