1754 papers
This study demonstrates that a novel targeted lipid nanoparticle formulation, incorporating a morpholine-based ionizable lipid and a lactobionic-octadecylamine conjugate, efficiently delivers siRNA to hepatocytes to achieve robust knockdown of antithrombin III with low cytotoxicity, offering a promising therapeutic strategy for bleeding disorders.
This study integrates transcriptomic data from 165 blood samples to identify 59 master regulator genes, including the universal biomarker DMTF1 and mood-state-specific regulators, which illuminate distinct biological processes underlying bipolar disorder across acute episodes and remission.
This study presents a bioengineered, vascularized melanoma-skin-on-a-chip platform utilizing an edgeless 3D reconstruction strategy to accurately mimic the human tumor microenvironment, thereby enabling the investigation of melanoma invasion dynamics and the evaluation of therapeutic responses.
This study challenges the conventional view of G-quadruplexes and i-motifs as mutually exclusive structures by demonstrating that G/C-rich tandem repeat sequences can form stable, pH-responsive hybrid architectures where protonation-dependent interactions couple these non-canonical conformations, thereby expanding our understanding of structural plasticity in genomic regions.
This study demonstrates that strontium toxicity in *Arabidopsis thaliana* arises from its inability to substitute for calcium, leading to disrupted calcium homeostasis, oxidative stress, membrane damage, and impaired peptide signaling, with the transporters OPT6 and CNGC9 identified as key mediators of strontium uptake and toxicity.
This study proposes a novel deep learning-based regression method utilizing the PIDE3.4 database that integrates physical and biological parameters to achieve accurate, spatially heterogeneous, and cross-cell generalizable predictions of Relative Biological Effectiveness (RBE) for optimizing particle therapy treatment planning.
This UK observational study reveals that Black pregnant women, particularly those living with HIV, experience higher rates of preterm birth associated with vaginal microbiota instability (specifically transitions between CST III and IV) and a higher prevalence of non-Lactobacillus-dominated communities, suggesting that these microbial patterns and adverse outcomes may be driven by broader socioeconomic determinants rather than HIV status alone.
This study reveals that the Bovine viral diarrhea virus (BVDV) Core protein reprograms host lipid metabolism by promoting lipid droplet biogenesis and facilitating their lipolysis-mediated transfer of fatty acids to mitochondria, thereby generating the energy required for efficient viral replication.
This study identifies the histone acetyltransferase p300 as a critical driver of cardiac aging by licensing SP1-mediated transcription of senescence effectors like p21 through H3K27ac-dependent chromatin remodeling, suggesting that inhibiting p300 can ameliorate cardiomyocyte senescence.
Exposure to the robber bee pheromone Citral triggers a significant increase in guard numbers and forager size in *Tetragonisca angustula* colonies while simultaneously reducing short-term pollen foraging, indicating that heightened defensive readiness comes at the cost of resource collection even without an actual attack.