🧬 Category

q-bio

1755 papers

🧬 biology

Estimating Dispersal, Survival time and Population size of Wild Aedes aegypti in Dar es Salaam, Tanzania using Self-Mark-Release-Recapture Method

This study utilized a self-mark-release-recapture method in Dar es Salaam, Tanzania, to determine that wild *Aedes aegypti* mosquitoes exhibit limited dispersal (mean 94.5m) and high survival rates (average 13.5 days), providing critical ecological parameters necessary for optimizing release-based vector control strategies against arboviral diseases.

Frank S.C. Tenywa, Haji Makame, Jason Moore, Osward Dogan, Harubu I. Mapipi, Thomas A. Smith, Nakul Chitnis, Sarah J. Mo (…)2026-06-29
🧬 biology

Frequency-Stratified Benchmarking Reveals Strong Long-Tail Limitations of Large Language Models in Diagnosis of Monogenic Diseases

This paper introduces MendelianBench-5K, a frequency-stratified benchmark of 5,000 cases, to demonstrate that large language models exhibit significant performance biases in diagnosing monogenic diseases, achieving high accuracy for well-studied genes while struggling with rare, recently characterized ones.

Jihao Cai, Jianle Yang, Maimaitiyibubaji Abudukadier, Aoxiang Luo, Lina Zhao, Guozhuang Li, Kexin Xu, Zhihong Wu, Terry (…)2026-06-29
🧬 biology

Multi-predictor pathogenicity filtering and membrane-specific stability analysis identify and characterize candidate destabilizing missense variants of the GIP receptor (GIPR)

By integrating multi-predictor pathogenicity filtering with membrane-specific stability analysis, this study identifies and characterizes 14 rare, structurally destabilizing missense variants in the GIP receptor (GIPR) that are likely to impact function and serve as a foundation for future pharmacogenetic research.

Sabbir Ahmad Antor, Mahjabin, Nurnabi Azad Jewel2026-06-29
🧬 biology

Artificial Intelligence-Driven Insights into the Antioxidant and Anticancer Properties of Onion (Allium cepa) and Tomato (Solanum lycopersicum) in Prostate Cancer Prevention and Management: A Contemporary Review

This contemporary review synthesizes evidence on the antioxidant and anticancer properties of onion and tomato phytochemicals in prostate cancer prevention, highlighting how artificial intelligence-driven approaches like molecular docking and machine learning can overcome current translational barriers by systematically prioritizing bioactive compounds and elucidating their molecular mechanisms despite existing clinical ambiguities.

Alli Ayobami O.2026-06-29
🧬 biology

Hierarchically supervised computational pathology stratifies HER2 categories and ERBB2 amplification risk from routine H&E slides in breast cancer

The paper introduces CHERISH, a hierarchically supervised computational pathology framework that leverages routine H&E slides to accurately stratify HER2 categories and predict ERBB2 amplification risk by embedding clinical testing logic into its architecture, thereby overcoming the limitations of conventional models and reducing the need for resource-intensive confirmatory testing.

Xiaohua Zeng, Yansong Ba, Long Wang, Xiaomin Xiong, Xin Zhou, Qingming Jiang, Sihao Liu, Shanqi Li, Zhigang Pei, Tao Zha (…)2026-06-29
🧬 biology

Causal Responsibility Based Explainable AI for Vibrational Spectroscopy Applied to Cancer Diagnostics

This paper introduces Spec-ReX, a causal responsibility-based Explainable AI method for vibrational spectroscopy in cancer diagnostics, and rigorously validates its performance against other XAI techniques across in silico, in vitro, and ex vivo datasets to address the critical need for transparent clinical decision-making.

Nathan Blake, David Kelly, Sarah Kapllani-Mucaj, Rong Wang, Geraint Thomas, Hana Chockler2026-06-29
🧬 biology

The Artemis I mission reshaped seed amino acid composition and post-flight plant growth in a genotype-dependent manner

The Artemis I mission induced genotype-dependent changes in seed amino acid profiles and post-flight growth in *Arabidopsis thaliana*, revealing that branched-chain amino acid metabolism is a critical factor influencing plant responses to deep-space exposure.

Joanne E Thomson, Evan Angelos, Ramona Gaza, Dinah Dimapilis, Ye Zhang, Kamber Scott, James O’Keefe, Federica Brandizzi2026-06-29
🧬 biology

Genetic dissection of dynamic leaf area index variation in maize using UAV-based phenotyping and time-series genome-wide association studies

This study establishes a robust framework integrating UAV-based multispectral phenotyping and time-series genome-wide association studies to identify dynamic genetic loci and the candidate gene *Zm00001d048615* that regulate maize leaf area index, offering valuable targets for improving canopy architecture and yield.

Xuyang Wang, Jiaojiao Ren, Penghao Wu2026-06-29