3881 papers
This study demonstrates that the baseline spatial organization of voltage-gated calcium channels relative to release sites dictates the capacity for presynaptic plasticity, revealing that only GABA synapses—unlike glutamate synapses—can undergo potentiation through a dramatic reorganization of calcium channel clusters that increases release probability.
This study reveals that the maturity of the meiotic spindle at the time of freezing determines human oocyte resilience to cryopreservation, as mature spindles withstand osmotic stress during thawing while immature ones suffer destabilization leading to segregation errors.
This study integrates bulk and single-cell RNA sequencing to identify a four-gene psychological stress-related signature (CCNB1, TLR4, CCNA2, and EXO1) that effectively stratifies lung adenocarcinoma patients by risk, reveals associations with cell-cycle and immune mechanisms, and predicts chemotherapy sensitivity.
This study reveals that cancer patients exhibit impaired long-term humoral immunity following SARS-CoV-2 vaccination due to B cell–intrinsic defects characterized by reduced somatic hypermutation and aberrant differentiation into atypical T-bet+ populations, a condition that can be mitigated by administering a fourth vaccine dose.
This study reveals that following a flood-induced shutdown, the biofiltration stage of a municipal wastewater treatment plant became a significant hotspot for the proliferation and persistence of antibiotic-resistant bacteria and genes, with effluent levels of ESBL and carbapenemase-resistant organisms increasing dramatically and showing strong multi-gene co-occurrence.
This study employs an integrative computational framework combining network toxicology, transcriptomics, and structural modeling to prioritize ERBB2 as a key molecular target linking tert-butylhydroquinone (TBHQ) to neuroblastoma, thereby establishing a hypothesis-driven foundation for future experimental validation.
Through genome-wide association studies of over 3,000 African children, this research elucidates the complex interplay between host genetics, blood group antigens, and rotavirus immunity, identifying a novel LIMS1/HGF signaling pathway that influences anti-rotavirus IgA responses and disease severity to inform the development of more effective vaccines.
This study demonstrates that long-range retrograde signaling via the Gdnf receptor Ret stabilizes pioneer neuronal identity and drives functional diversification in the zebrafish posterior lateral line circuit by coupling target-derived cues to specific transcriptional and physiological programs.
Using wide-field mesoscale calcium imaging in Shank3B-deficient mice, this study reveals that disruption of the autism-risk gene SHANK3 drives a widespread dorsal cortical hyperactive state that amplifies, destabilizes, and accelerates sensory responses, providing a circuit-level explanation for sensory hyper-responsivity in autism.
This paper establishes the well-posedness of a mechanochemical plate-diffusion model coupling tissue deformation and morphogen concentration, and through spectral analysis, demonstrates that the sign of deformation-to-morphogen feedback critically determines the stability of the homogeneous state, thereby identifying the linear instability mechanisms that precede nonlinear pattern formation.