3881 papers
This study demonstrates that both silver citrate and silver polyvinylpyrrolidone nanoparticles induce cytotoxicity and cell death in HeLa cervical cancer cells, with silver citrate showing stronger morphological effects and caspase-3 activity while silver polyvinylpyrrolidone elicited higher superoxide dismutase activity.
This study identifies epigenome-wide DNA methylation signatures in peripheral blood associated with combined hormonal contraceptive use and hormonal trajectories, which correlate with synthetic hormone concentrations but not with depressive symptoms or endogenous hormone levels.
This study demonstrates that mitochondrial transcriptomic responses to real spaceflight in mice vary significantly across tissue and mission contexts, revealing a consistent but imprecise suppression in muscle while liver and retina responses lack stable directional trends and are highly sensitive to analytical methods.
This study demonstrates that a two-phase enrichment strategy using cork as a co-substrate successfully selects mangrove-derived microbial consortia capable of degrading PET, revealing specific taxa such as *Amycolatopsis*, *Nocardopsis*, *Streptomyces*, and *Ramlibacter* that harbor genes for PET depolymerization.
This study utilizes single-cell transcriptomics to identify youth-specific hypermetabolic epithelial subpopulations driven by oxidative phosphorylation in young breast cancer patients, revealing a distinct age-dependent evolutionary trajectory and establishing OXPHOS inhibition as a promising targeted therapeutic strategy.
To address the under-representation of French ancestry in global genomic databases, this study presents the FranceGenRef panel, a whole-genome reference resource derived from 856 individuals with deep regional roots that catalogs genetic variants and their geographical distribution across metropolitan France to support future genomic medicine and research.
EIHR-PROT is a novel protein function prediction framework that outperforms existing methods by adaptively integrating ESM-2 sequence embeddings with homology-based priors through a learned gating mechanism that explicitly models the reliability of homology evidence.
This study presents a novel, rapid, and cost-effective lateral flow immunochromatographic assay that utilizes a two-step incubation protocol and chemiluminescent detection to achieve highly sensitive, quantitative measurement of small extracellular vesicles (CD9) with a detection limit 40–60 times lower than conventional colorimetric methods, offering a versatile dual-modality platform for clinical liquid biopsies.
This study integrates genetic and pathway profiling of focal isolated dystonia patients to demonstrate that diverse genetic mutations converge on interconnected biological networks involving mitochondrial function, neurotransmitter synthesis, ion channel activity, and transcriptional regulation, thereby supporting the development of pathway-oriented therapeutic strategies.
This paper introduces descSPIM-Advanced, a versatile and cost-effective off-the-shelf light-sheet microscopy ecosystem that unifies high-resolution, multicolor, and large-field-of-view imaging capabilities through interoperable variants and a standardized control system to democratize 3D cleared-tissue imaging.