3881 papers
This study employs a multi-layered in silico pipeline to identify a TssM deubiquitinase ortholog in the clinical isolate *Burkholderia pseudomallei* CM000113 as a critical virulence factor that facilitates immune evasion by forming stable complexes with host HLA molecules.
This study demonstrates that c-MET aberrations drive breast cancer metastasis in a human HGF-dominant environment through a newly identified crosstalk with FGFR3 that activates EMT and immunosuppression, suggesting that combined targeting of MET and FGFR3 is a promising therapeutic strategy.
This study identifies short tandem repeat (STR) polymorphisms as a significant source of "missing heritability" in *Plasmodium falciparum* artemisinin partial resistance by demonstrating that specific STRs regulate gene expression and are strongly associated with the resistance phenotype, thereby revealing novel potential markers like falcipain 2b and MAK16.
Using a densely sampled longitudinal dataset, this study reveals that short-timescale fluctuation asymmetry (FLARe) serves as a prospective predictor of the transition from local to distributed functional connectome integration and the development of visually guided behaviors during the first six months of infancy.
By developing a media- and ploidy-optimized multiplexed assay in HAP1 cells, this study functionally characterizes SDHB exon 3 variants to reclassify approximately 87% of previously uncertain variants as either pathogenic or benign, thereby significantly reducing the clinical burden of variants of uncertain significance in hereditary pheochromocytoma and paraganglioma.
The study introduces Polytech-CyanoSPO, a chemically rationalized BG11 derivative that overcomes precipitation and toxicity issues through four targeted salt substitutions, thereby enabling robust growth and metabolic activity in three toxigenic cyanobacterial strains that fail to thrive in standard BG11 medium.
This study demonstrates that a living deep reservoir computing system, constructed using a microfluidic chip with unidirectional axon-routing channels to enforce directed signal propagation, outperforms a bidirectional control group in time-series prediction and music classification tasks, thereby establishing a novel paradigm for high-efficiency bio-hybrid computing.
This study demonstrates that perinatal chorioamnionitis induces persistent dysregulation of heme oxygenase-1 (HO-1) expression across distinct microglial subpopulations in adult rats, indicating a lasting oxidative microenvironment in the brain.
This study presents a computational workflow integrating NCBI, CHOPCHOP, and Cas-OFFinder to design and evaluate CRISPR-Cas9 guide RNAs targeting rare HBB gene mutations beyond HbS and β-thalassemia, providing a pre-experimental framework that requires subsequent biological validation.
This study demonstrates that the territorial calls of Blue Petrels on Diego Ramírez Island exhibit distinct sexual differences, particularly in the number of elements and delta time, while also revealing significant individual vocal signatures and intrapopulation acoustic variation.