1807 papers
This study characterizes hypermutated microsatellite stable tumors across colorectal and endometrial cancers as a distinct biological subgroup defined by shared upregulation of immune and proliferative pathways (such as mTORC1, E2F, and G2M checkpoints) alongside cancer-specific regulatory features, notably involving SLC7A11 and microRNA interactions.
This study utilized genome-wide association analyses to demonstrate that universal folic acid fortification is associated with shifts in the prevalence of specific genetic variants in cardiac developmental pathways, particularly within the DHRS3 and PPARGC1β genes, among children with conotruncal heart defects.
This study demonstrates that disrupting lysine biosynthesis via DAPAT deficiency in *Arabidopsis thaliana* reprograms developmental timing and reproductive output by altering DNA methylation patterns and the expression of key flowering regulators, thereby revealing a critical metabolic-epigenetic link between amino acid metabolism and plant growth.
This study demonstrates that a novel targeted lipid nanoparticle formulation, incorporating a morpholine-based ionizable lipid and a lactobionic-octadecylamine conjugate, efficiently delivers siRNA to hepatocytes to achieve robust knockdown of antithrombin III with low cytotoxicity, offering a promising therapeutic strategy for bleeding disorders.
This study integrates transcriptomic data from 165 blood samples to identify 59 master regulator genes, including the universal biomarker DMTF1 and mood-state-specific regulators, which illuminate distinct biological processes underlying bipolar disorder across acute episodes and remission.
This study presents a bioengineered, vascularized melanoma-skin-on-a-chip platform utilizing an edgeless 3D reconstruction strategy to accurately mimic the human tumor microenvironment, thereby enabling the investigation of melanoma invasion dynamics and the evaluation of therapeutic responses.
This study challenges the conventional view of G-quadruplexes and i-motifs as mutually exclusive structures by demonstrating that G/C-rich tandem repeat sequences can form stable, pH-responsive hybrid architectures where protonation-dependent interactions couple these non-canonical conformations, thereby expanding our understanding of structural plasticity in genomic regions.
This study demonstrates that strontium toxicity in *Arabidopsis thaliana* arises from its inability to substitute for calcium, leading to disrupted calcium homeostasis, oxidative stress, membrane damage, and impaired peptide signaling, with the transporters OPT6 and CNGC9 identified as key mediators of strontium uptake and toxicity.
This study proposes a novel deep learning-based regression method utilizing the PIDE3.4 database that integrates physical and biological parameters to achieve accurate, spatially heterogeneous, and cross-cell generalizable predictions of Relative Biological Effectiveness (RBE) for optimizing particle therapy treatment planning.
This UK observational study reveals that Black pregnant women, particularly those living with HIV, experience higher rates of preterm birth associated with vaginal microbiota instability (specifically transitions between CST III and IV) and a higher prevalence of non-Lactobacillus-dominated communities, suggesting that these microbial patterns and adverse outcomes may be driven by broader socioeconomic determinants rather than HIV status alone.