1812 papers
This study proposes a novel deep learning-based regression method utilizing the PIDE3.4 database that integrates physical and biological parameters to achieve accurate, spatially heterogeneous, and cross-cell generalizable predictions of Relative Biological Effectiveness (RBE) for optimizing particle therapy treatment planning.
This UK observational study reveals that Black pregnant women, particularly those living with HIV, experience higher rates of preterm birth associated with vaginal microbiota instability (specifically transitions between CST III and IV) and a higher prevalence of non-Lactobacillus-dominated communities, suggesting that these microbial patterns and adverse outcomes may be driven by broader socioeconomic determinants rather than HIV status alone.
This study reveals that the Bovine viral diarrhea virus (BVDV) Core protein reprograms host lipid metabolism by promoting lipid droplet biogenesis and facilitating their lipolysis-mediated transfer of fatty acids to mitochondria, thereby generating the energy required for efficient viral replication.
This study identifies the histone acetyltransferase p300 as a critical driver of cardiac aging by licensing SP1-mediated transcription of senescence effectors like p21 through H3K27ac-dependent chromatin remodeling, suggesting that inhibiting p300 can ameliorate cardiomyocyte senescence.
Exposure to the robber bee pheromone Citral triggers a significant increase in guard numbers and forager size in *Tetragonisca angustula* colonies while simultaneously reducing short-term pollen foraging, indicating that heightened defensive readiness comes at the cost of resource collection even without an actual attack.
This study reveals that alcohol use disorder severity arises through distinct neurocognitive pathways depending on the presence of comorbid social anxiety disorder, with AUD alone linked to reduced ventral attention network activation and AUD with comorbid SAD linked to reduced default mode network activation mediated by coping drinking motives.
This study validates Hydrostatic Filtration as a structurally conservative alternative to ultracentrifugation for isolating *Lacticaseibacillus casei* BL23 extracellular vesicles, while revealing that standard ultracentrifugation workflows exclude a distinct population of non-vesicular, 8-nm extracellular particles enriched in cell wall hydrolases.
This study demonstrates that immune checkpoint receptor expression in human γδ T cells is driven by activation-associated, lineage-specific, and context-dependent dynamics rather than a uniform exhaustion state, revealing distinct regulatory patterns and functional responses compared to αβ T cells.
This study demonstrates that while implicit visual feedback manipulation can modulate the upper limits of maximal motor performance, this effect is constrained by the magnitude of the discrepancy and is partially suppressed—but not eliminated—when participants possess explicit knowledge of the manipulation.
This study identifies a calcium-calpain-ALIX signaling axis as the critical mechanism that converts reversible Gasdermin-D pore formation into irreversible pyroptotic cell death by triggering calcium influx to cleave the membrane repair protein ALIX, thereby disabling the ESCRT machinery and preventing membrane repair.