1816 papers
This study identifies the histone acetyltransferase p300 as a critical driver of cardiac aging by licensing SP1-mediated transcription of senescence effectors like p21 through H3K27ac-dependent chromatin remodeling, suggesting that inhibiting p300 can ameliorate cardiomyocyte senescence.
Exposure to the robber bee pheromone Citral triggers a significant increase in guard numbers and forager size in *Tetragonisca angustula* colonies while simultaneously reducing short-term pollen foraging, indicating that heightened defensive readiness comes at the cost of resource collection even without an actual attack.
This study reveals that alcohol use disorder severity arises through distinct neurocognitive pathways depending on the presence of comorbid social anxiety disorder, with AUD alone linked to reduced ventral attention network activation and AUD with comorbid SAD linked to reduced default mode network activation mediated by coping drinking motives.
This study validates Hydrostatic Filtration as a structurally conservative alternative to ultracentrifugation for isolating *Lacticaseibacillus casei* BL23 extracellular vesicles, while revealing that standard ultracentrifugation workflows exclude a distinct population of non-vesicular, 8-nm extracellular particles enriched in cell wall hydrolases.
This study demonstrates that immune checkpoint receptor expression in human γδ T cells is driven by activation-associated, lineage-specific, and context-dependent dynamics rather than a uniform exhaustion state, revealing distinct regulatory patterns and functional responses compared to αβ T cells.
This study demonstrates that while implicit visual feedback manipulation can modulate the upper limits of maximal motor performance, this effect is constrained by the magnitude of the discrepancy and is partially suppressed—but not eliminated—when participants possess explicit knowledge of the manipulation.
This study identifies a calcium-calpain-ALIX signaling axis as the critical mechanism that converts reversible Gasdermin-D pore formation into irreversible pyroptotic cell death by triggering calcium influx to cleave the membrane repair protein ALIX, thereby disabling the ESCRT machinery and preventing membrane repair.
This study identifies SMAD2 as a critical regulatory hub in mast cells that integrates TGF-β and antigen signaling to simultaneously control cell proliferation, survival, and the production of both anti-inflammatory and pro-inflammatory responses.
This paper introduces an information-geometric framework that reframes latent dimension selection for macromolecular ensembles as a thermodynamic optimization problem, deriving a three-stage protocol to identify the optimal dimensionality by quantifying compression costs and geometric distortions, thereby outperforming existing statistical heuristics in recovering physically meaningful representations.
This study demonstrates that antibody binding induces "focused flexibility"—a state of local antigen destabilization at the epitope interface coupled with global stabilization—which, in conjunction with FcRn-mediated endosomal sorting, creates an optimally unstable processing intermediate that dramatically enhances the efficiency of CD4+ T cell epitope generation.