3897 papers
This study presents a hybrid computational framework combining stochastic spatial point processes and explainable 3D deep learning to reveal that while global microglial distribution remains unchanged in Parkinson's disease, there is a significant, region-specific increase in microglial-pSyn co-occupancy in the substantia nigra driven by distinct micro-morphological texture gradients.
This study proposes an alignment-free phylogenetic analysis framework that integrates k-mer statistics with DNA physicochemical properties and strand symmetry into a feature vector, which is then optimized using an enhanced rough set-based selection method to achieve efficient and interpretable whole-genome evolutionary inference.
This study introduces SENSE2, a histology-informed computational framework that integrates time-dependent tissue remodeling to quantitatively compare the long-term performance, stability, and selectivity of three peripheral nerve implant designs over five months, revealing that accounting for chronic foreign body response is essential for optimizing neuromodulation efficacy.
This proof-of-concept study demonstrates that a novel, personalized transcranial magnetic stimulation (TMS)-based brain-computer interface combined with motor imagery and neurofeedback enables healthy adults to successfully modulate brain activity and decode complex, distinct hand actions, highlighting its potential for neurorehabilitation in individuals with severe motor impairments.
This descriptive secondary analysis systematically examines S100A8/A9-TLR4 transcript and co-expression patterns across public mouse myocardial ischemia-reperfusion datasets and a human CMR-defined microvascular obstruction thrombus proteomic resource, generating hypothesis-generating insights while explicitly noting the absence of established functional causality or clinical prediction.
This study identifies the circCRIM1–miR-320c–MMP16 axis as a critical regulator of cartilage homeostasis in osteoarthritis, where upregulated circCRIM1 sponges miR-320c to derepress MMP16, impairing chondrogenesis and driving disease progression, thus highlighting its potential as a therapeutic target.
This study demonstrates that miR-143-3p acts as a tumor suppressor in cervical squamous cell carcinoma by directly targeting and downregulating SLC7A11 to induce ferroptosis and inhibit epithelial–mesenchymal transition, thereby suppressing malignant behavior.
This study integrates multi-cohort bulk and single-cell transcriptomic data to demonstrate that proteostasis dysregulation in Alzheimer's disease is consistently suppressed across cohorts, characterized by an interpretable diagnostic signature centered on KLF15, and driven by a specific KLF15–LRRTM4 regulatory axis within astrocytes.
This study reveals that the long non-coding RNA LNCTAM34A promotes endometrial carcinoma progression by upregulating C4orf47 through the suppression of miR-34a, a mechanism validated by single-cell transcriptomics and functional assays showing enhanced epithelial cell invasion and proliferation.
This study demonstrates that the transition to parenthood reveals adaptation as a multidimensional process where subjective and biological indicators provide complementary, rather than interchangeable, insights, as evidenced by improved life satisfaction and biological health despite the absence of broad deterioration in other stress-related domains.