q-bio papers | Gist.Science

Mechanochemical Pattern Formation in a Morphogen-Coupled Tissue Plate: Well-Posedness, Instability Thresholds, and Nonlinear Dynamics

This paper establishes the well-posedness of a mechanochemical plate-diffusion model coupling tissue deformation and morphogen concentration, and through spectral analysis, demonstrates that the sign of deformation-to-morphogen feedback critically determines the stability of the homogeneous state, thereby identifying the linear instability mechanisms that precede nonlinear pattern formation.

Taylan Demi̇r, Niaz Ali Shah2026-08-22

🧬 biology

Investigating The Cytotoxic Effects Of Coated Silver Nanoparticles On Cancer Cervical Cells

This study demonstrates that both silver citrate and silver polyvinylpyrrolidone nanoparticles induce cytotoxicity and cell death in HeLa cervical cancer cells, with silver citrate showing stronger morphological effects and caspase-3 activity while silver polyvinylpyrrolidone elicited higher superoxide dismutase activity.

Girlie Tambirai Mapere, Lemme P Kebaabetswe2026-08-22

🧬 biology

Epigenome-wide DNA methylation signatures associated with combined hormonal contraceptive use

This study identifies epigenome-wide DNA methylation signatures in peripheral blood associated with combined hormonal contraceptive use and hormonal trajectories, which correlate with synthetic hormone concentrations but not with depressive symptoms or endogenous hormone levels.

Mirac Nur Musaoğlu, Lea Zillich, Susanne Edelmann, Erika Comasco, Birgit Derntl, Ann-Christin S. Kimmig, Vanessa Nierats (…)2026-08-22

🧬 biology

Mitochondrial transcriptomic responses to real spaceflight vary across mouse tissue-mission contexts

This study demonstrates that mitochondrial transcriptomic responses to real spaceflight in mice vary significantly across tissue and mission contexts, revealing a consistent but imprecise suppression in muscle while liver and retina responses lack stable directional trends and are highly sensitive to analytical methods.

Saket Ganti2026-08-22

🧬 biology

Detection of candidate PET-active species in mangrove-derived microbial consortia

This study demonstrates that a two-phase enrichment strategy using cork as a co-substrate successfully selects mangrove-derived microbial consortia capable of degrading PET, revealing specific taxa such as *Amycolatopsis*, *Nocardopsis*, *Streptomyces*, and *Ramlibacter* that harbor genes for PET depolymerization.

Lila Aldakheel, Rubén Díaz-Rúa, Xiang Zhao, Semidán Robaina-Estévez, Alexandre S. Rosado, Diego J. Jiménez2026-08-21

🧬 biology

Single-cell transcriptomics reveals age-specific epithelial evolution and metabolic vulnerability in young breast cancer

This study utilizes single-cell transcriptomics to identify youth-specific hypermetabolic epithelial subpopulations driven by oxidative phosphorylation in young breast cancer patients, revealing a distinct age-dependent evolutionary trajectory and establishing OXPHOS inhibition as a promising targeted therapeutic strategy.

JiangYang Wan, Rui Peng Zhao, Chen Zhang, Wei Song, LinLin Zhen, DongZhu Da, Zhi Li2026-08-21

🧬 biology

FranceGenRef: first steps towards a whole-genome reference panel grounded in French regional ancestral diversity

To address the under-representation of French ancestry in global genomic databases, this study presents the FranceGenRef panel, a whole-genome reference resource derived from 856 individuals with deep regional roots that catalogs genetic variants and their geographical distribution across metropolitan France to support future genomic medicine and research.

Emmanuelle Génin, Pierre Lindenbaum, Damien Delafoy, Florian Sandron, Véronique Geoffroy, Gaelle Marenne, Anthony Herzig (…)2026-08-21

🧬 biology

EIHR-PROT: Explicitly Modelling of Homology Reliability for Protein Function Prediction

EIHR-PROT is a novel protein function prediction framework that outperforms existing methods by adaptively integrating ESM-2 sequence embeddings with homology-based priors through a learned gating mechanism that explicitly models the reliability of homology evidence.

Oluranti Jonathan, Uwidia . E. Osalodion2026-08-21

🧬 biology

Development of a Highly Sensitive and Rapid Lateral Flow Immunochromatographic Assay for the Quantitative Detection of Small Extracellular Vesicles

This study presents a novel, rapid, and cost-effective lateral flow immunochromatographic assay that utilizes a two-step incubation protocol and chemiluminescent detection to achieve highly sensitive, quantitative measurement of small extracellular vesicles (CD9) with a detection limit 40–60 times lower than conventional colorimetric methods, offering a versatile dual-modality platform for clinical liquid biopsies.

Makoto Watanabe, Yuta Miyazawa, Takashi Yamasaki, Yoshikazu So, Taka-Aki Sato2026-08-21

🧬 biology

Integrative Genetic and Pathway Profiling Reveals the Molecular Landscape of Dystonia

This study integrates genetic and pathway profiling of focal isolated dystonia patients to demonstrate that diverse genetic mutations converge on interconnected biological networks involving mitochondrial function, neurotransmitter synthesis, ion channel activity, and transcriptional regulation, thereby supporting the development of pathway-oriented therapeutic strategies.

Neetu Rani Dhiman, Surbhi Singh, Deepika Joshi, Royana Singh, Ashish Ashish, Shivani Mishra, Anand Kumar, Varun Kumar Si (…)2026-08-21

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