3965 papers
This study demonstrates that long-range retrograde signaling via the Gdnf receptor Ret stabilizes pioneer neuronal identity and drives functional diversification in the zebrafish posterior lateral line circuit by coupling target-derived cues to specific transcriptional and physiological programs.
Using wide-field mesoscale calcium imaging in Shank3B-deficient mice, this study reveals that disruption of the autism-risk gene SHANK3 drives a widespread dorsal cortical hyperactive state that amplifies, destabilizes, and accelerates sensory responses, providing a circuit-level explanation for sensory hyper-responsivity in autism.
This paper establishes the well-posedness of a mechanochemical plate-diffusion model coupling tissue deformation and morphogen concentration, and through spectral analysis, demonstrates that the sign of deformation-to-morphogen feedback critically determines the stability of the homogeneous state, thereby identifying the linear instability mechanisms that precede nonlinear pattern formation.
This study demonstrates that both silver citrate and silver polyvinylpyrrolidone nanoparticles induce cytotoxicity and cell death in HeLa cervical cancer cells, with silver citrate showing stronger morphological effects and caspase-3 activity while silver polyvinylpyrrolidone elicited higher superoxide dismutase activity.
This study identifies epigenome-wide DNA methylation signatures in peripheral blood associated with combined hormonal contraceptive use and hormonal trajectories, which correlate with synthetic hormone concentrations but not with depressive symptoms or endogenous hormone levels.
This study demonstrates that mitochondrial transcriptomic responses to real spaceflight in mice vary significantly across tissue and mission contexts, revealing a consistent but imprecise suppression in muscle while liver and retina responses lack stable directional trends and are highly sensitive to analytical methods.
This study demonstrates that a two-phase enrichment strategy using cork as a co-substrate successfully selects mangrove-derived microbial consortia capable of degrading PET, revealing specific taxa such as *Amycolatopsis*, *Nocardopsis*, *Streptomyces*, and *Ramlibacter* that harbor genes for PET depolymerization.
This study utilizes single-cell transcriptomics to identify youth-specific hypermetabolic epithelial subpopulations driven by oxidative phosphorylation in young breast cancer patients, revealing a distinct age-dependent evolutionary trajectory and establishing OXPHOS inhibition as a promising targeted therapeutic strategy.
To address the under-representation of French ancestry in global genomic databases, this study presents the FranceGenRef panel, a whole-genome reference resource derived from 856 individuals with deep regional roots that catalogs genetic variants and their geographical distribution across metropolitan France to support future genomic medicine and research.
EIHR-PROT is a novel protein function prediction framework that outperforms existing methods by adaptively integrating ESM-2 sequence embeddings with homology-based priors through a learned gating mechanism that explicitly models the reliability of homology evidence.