🧬 biology

Response to environmental stress through a combination of dispersal and outcrossing strategies in Lamium amplexicaule

This study demonstrates that the annual plant *Lamium amplexicaule* employs a coordinated Fitness Associated Dispersal strategy under salt stress, where individuals with higher outcrossing potential produce seeds with specific morphological traits that enhance both seed and pollen dispersal to escape maladaptive environments.

Mor Binder, Oren Rabinowitz, Bayan Bashir, Lilach Hadany, Nir Ohad2026-08-20
🧬 biology

Astragalus polysaccharide ameliorates adipogenic skewing and dysfunction of bone marrow mesenchymal stromal cells in aplastic anemia via mTOR inhibition

Astragalus polysaccharide (APS) ameliorates the proliferation defects, apoptosis, and aberrant adipogenic differentiation of bone marrow mesenchymal stromal cells in aplastic anemia by inhibiting the mTOR pathway, thereby restoring the hematopoietic-supportive stromal niche.

Xiaoyan Hou, Xiaoling Zhou, Jie Wang, Jing Huang, Boping Li, Liya Feng, Jinlong Kai2026-08-20
🧬 biology

Cannabigerol potentiates rivoceranib in hepatocellular carcinoma through a receptor-independent ER stress–calcium program that collapses the E2F1–FOXM1 axis

This study demonstrates that the non-psychoactive cannabinoid cannabigerol (CBG) synergizes with the VEGFR2 inhibitor rivoceranib to induce hepatocellular carcinoma cell death via a receptor-independent mechanism involving ER stress-driven calcium overload that collapses the E2F1–FOXM1 axis, thereby converting rivoceranib into a tumor-cell-intrinsic therapy.

Young-Joo Kim, Youngsic Jeon, Hyukjoon Kwon, Taejung Kim, Masaud Shah, Hyunhee Kim, Hee-Bum Kang, Sang Hoon Jung, Hyun G (…)2026-08-20
🧬 biology

The orphan DNA methyltransferase VchM prevents autoimmunity from a type II Menshen system in Vibrio cholerae

This study reveals that the orphan DNA methyltransferase VchM prevents autoimmunity in *Vibrio cholerae* by methylating DNA to suppress the activation of the adjacent Menshen defense system, which otherwise disrupts ribosome biogenesis and restricts horizontal gene transfer.

Zeynep Baharoglu, André Carvalho, Filipa Trigo da Roza, Jorge Moura de Sousa, Manon Lang, Didier Mazel, Jose Antonio Esc (…)2026-08-20
🧬 biology

Differential effects of hypnotizability on visuomotor adaptation and sequential motor learning

This study demonstrates that higher hypnotizability is associated with reduced visuomotor precision during perturbation but does not impair overall visuomotor adaptation or sequential motor learning, suggesting distinct neural mechanisms involving cerebellar and hemispheric functional asymmetries.

Eleonora Malloggi, Dmitrii Todorov, Guillaume Digonet, Enrica L. Santarcangelo, Ursula Debarnot2026-08-20
🧬 biology

Decision strategies appear similar across species and development, but differences emerge in the speed-accuracy relationship

By combining Conditional Accuracy Functions and Drift Diffusion Modeling, this study reveals that while humans and macaques share an evolutionarily conserved decision-making framework involving collapsing boundaries, children exhibit distinct fast-error patterns driven by unstable initial decision states likely due to immature frontostriatal networks.

Mariella Segreti, Sara Dal Sasso, Fabio Di Bello, Giampiero Bardella, Ann Paul, Surabhi Ramawat, Deny Menghini, Ferraina (…)2026-08-20
🧬 biology

Identification and characterization of the CCoAOMT gene family in walnut and the regulatory function of JrCCoAOMT3 in lignin biosynthesis

This study identifies the walnut CCoAOMT gene family and demonstrates that the specific member JrCCoAOMT3 acts as a key regulator of lignin biosynthesis by altering monomer composition, particularly reducing H-type lignin, thereby providing molecular insights for improving walnut shell hardness.

Ruixia Gao, Shangqi Yu, Yonglin Shao, Qian Ye, Xingyu Guo, Shan Gao, Yongqiang Chen, Qiang Jin, Rui Zhang, Zhongzhong Gu (…)2026-08-20