4041 papers
This study demonstrates that ultra-microelectrodes (5–10 µm) enable low-threshold intracortical microstimulation with superior amplitude discrimination in rats by operating at lower reference amplitudes within safe charge injection limits while maintaining proportional psychophysical scaling.
This study identifies and functionally validates a novel deep-intronic *TBX5* variant as the first regulatory splicing mutation causing Holt-Oram syndrome, demonstrating the critical necessity of RNA analysis for characterizing non-coding pathogenic variants.
Despite extensive multi-year sampling across the South Shetland Islands, this study reveals that *Bacillus cereus* group bacteria are extremely rare and spatially restricted exclusively to King George Island in modern Antarctica.
This study characterizes the Neotropical banjo catfish *Bunocephalus aloikae* as a powerful model for understanding extreme genome plasticity, revealing its remarkable tolerance for individual-specific large-scale chromosomal rearrangements and the inheritance of male-linked B chromosomes despite the absence of a stable sex chromosome system.
This study demonstrates that voluntary exercise ameliorates sarcopenia and metabolic dysfunction–associated steatohepatitis in aged mice by activating skeletal muscle PGC-1α/SIRT1 signaling to suppress TNF-α-mediated inflammation, thereby improving both muscle and liver pathology through local metabolic remodeling rather than systemic myokine release.
This study provides the first molecular confirmation and distributional refinement of the Bhutan takin (*Budorcas taxicolor whitei*) in Arunachal Pradesh, India, by integrating camera trapping, morphological observations, and mitochondrial DNA analysis to validate its presence and expand its known range in the Eastern Himalaya.
This study demonstrates that Outer Membrane Vesicles (OMVs) derived from *Klebsiella pneumoniae*, particularly those from biofilm states, enhance biofilm formation and matrix integrity by delivering biofilm-associated mRNAs, including those encoding quorum sensing components, thereby revealing a novel mechanism for biofilm regulation and a potential therapeutic target.
This study establishes a scalable human pluripotent stem cell-derived sensory neuron model that faithfully recapitulates the metabolic and morphological features of diabetic peripheral neuropathy, demonstrating its utility for evaluating the neuroprotective efficacy of agents like N-acetylcysteine, minocycline, and metformin against oxidative stress-induced axonal degeneration.
The study presents a human lung organoid-on-a-chip model that successfully recapitulates native airway complexity and reveals conserved SARS-CoV-2-induced epithelial remodeling and vascular angiogenic responses across multiple viral variants, offering a physiologically relevant platform for respiratory disease research.
This paper proposes a biophysical hypothesis that asymmetric G-overhang lengths at telomeres generate localized electrostatic field gradients capable of influencing shelterin binding and T-loop dynamics, supported by computational predictions and outlining specific experimental strategies to validate this mechanism against alternative models.