1820 papers
This study demonstrates that high expression of cellular prion protein (PrPC) drives gastric cancer progression by promoting epithelial-mesenchymal transition (EMT) and correlates significantly with poor prognosis, establishing it as a valuable prognostic biomarker and potential therapeutic target.
This study reveals that 100% of naira notes collected from food sellers in Jos South, Nigeria, are contaminated with pathogenic and multidrug-resistant bacteria, with contamination levels significantly higher on physically worn notes regardless of denomination.
This study utilizes single-cell RNA sequencing to demonstrate that while both age and sex shape baseline lymphoid composition in murine sepsis, aging uniquely drives distinct transcriptional reprogramming, metabolic shifts, and altered drug response profiles in lymphocytes, whereas sex does not significantly modify the septic immune response.
By synthesizing botanical, geographical, linguistic, and literary evidence from sixteen sources, this paper definitively identifies the coastal Punnai tree of classical Tamil Sangam poetry as *Calophyllum inophyllum* L., distinguishing it from other South Indian *Calophyllum* species that inhabit mountainous regions.
This study introduces SDSGI, a computational framework that integrates expression specificity and statistical surprise scores to effectively identify subtype-specific long non-coding RNAs (lncRNAs) in tumor-infiltrating CD8+ T cells across multiple cancer types, thereby offering new insights into immune regulation and cancer prognosis.
This study demonstrates that adolescent social isolation, particularly when it occurs during early adolescence, produces enduring increases in alcohol consumption and aversion-resistant drinking in both male and female rats, though re-socialization appears to offer greater protective effects against these specific alcohol-related behaviors in females compared to males.
The FINDER platform achieves area-scalable, amplification-free attomolar biomarker detection by combining fluorogenic transient probes with kinetic fingerprinting to suppress background noise and enable rapid single-molecule classification across large sensor areas.
This study demonstrates that subchronic in vitro exposure to antipsychotics elicits drug-specific transcriptomic and epigenomic responses in microglia, where atypical agents like clozapine and aripiprazole broadly suppress neuroinflammation and promote neuroprotective phenotypes, while the typical agent haloperidol uniquely modulates microglia-neuron communication pathways.
This study demonstrates that ammonia exposure induces oxidative stress and cytotoxicity in grass carp liver cells (L8824) by disrupting redox homeostasis, a process in which the upregulated Srx1-Prx/Trx system plays a critical regulatory role.
This study characterizes the substrate specificity and genomic context of the oral bacterium *Tannerella forsythia*'s β-glucanase TfGlcA, revealing its unique preference for β1,3-linked polysaccharides and its association with a distinct regulatory module within a polysaccharide utilization locus, thereby highlighting its specific role in nutrient dynamics and pathobiont support within periodontal biofilms.