1820 papers
This study integrates multi-omic analyses to define a mito_lysis-like malignant program in clear cell renal cell carcinoma that is coupled with a TNFRSF12A-MAP3K14-VCAM1 inflammatory remodeling axis, linking mitochondrial stress in malignant cells to myeloid-driven niche interactions and poor patient survival.
This study elucidates the age-dependent intestinal maturation of 3- to 5-month-old yak calves by integrating morphological, microbial, and transcriptomic analyses to reveal progressive large intestine development, dynamic microbial succession, and the upregulation of immune-related genes and metabolic pathways that drive host–microbiota interactions.
This integrative multi-cohort study identifies hsa-miR-1277, hsa-miR-301b, and hsa-miR-519a-1 as novel miRNA candidates associated with oral squamous cell carcinoma molecular dysregulation, highlighting the disease's biological heterogeneity and the challenges in translating transcriptomic signatures into reproducible clinical biomarkers.
This study demonstrates that a representation learning framework applied to multimodal neuroimaging data can accurately identify systems-level brain signatures of traumatic brain injury in young adults and link specific structural and functional network alterations to the severity of attentional dysfunction.
This study challenges the prevailing view that pituitary hormones circulate as free proteins by demonstrating that multiple hormones in mammals form stable, conserved complexes with immunoglobulins, suggesting this macro-hormone state is a fundamental physiological feature rather than a rare pathological anomaly.
This review provides a comprehensive genome-wide characterization of the zebrafish *kmt2* (mll) histone methyltransferase gene family and utilizes *in silico* approaches to identify miRNAs that modulate its epigenetic regulatory mechanisms, thereby elucidating their critical roles in development and gene expression.
This study identifies the suppression of IRF8 in hematopoietic cells as a key driver of pathological bone marrow remodeling in chronic-phase myeloid leukemia, where its loss unleashes an S100A8/A9-mediated neutrophil alarmin program that activates stromal cells and amplifies disease progression.
This study utilizes comparative genomics and culture-based methods to characterize *Paenibacillus alvei* strain 32, a novel genomospecies isolated from cystic fibrosis sputum, and identifies a specific 110-kb non-ribosomal peptide synthetase gene cluster responsible for producing anti-MRSA paenialvins.
This biomechanical cadaveric study on ovine tibiae reveals that six months after tibial tuberosity advancement with cranial fixation, the regenerated bone at the osteotomy site exhibits significantly reduced stiffness and inferior, more variable mechanical properties compared to normal cortical bone, indicating that full mechanical maturation has not yet occurred despite radiographic healing.
This paper proposes a novel Bloch-sphere-based quantum color space that maps discrete RGB values to single-qubit state parameters organized by channel subgroups and azimuthal trajectories, enabling effective finite-shot reconstruction of images like MNIST and CIFAR-10 with high fidelity through deterministic decoding rules.