4041 papers
This study demonstrates that polystyrene microplastics act as a "Trojan horse" for cadmium in Nile tilapia, inducing synergistic toxicity characterized by severe oxidative stress, apoptosis, and genotoxicity that exceeds the sum of individual contaminant effects and results in incomplete recovery after exposure.
This study identifies the chitin deacetylase TlCDA from *Tilletia laevis* as a critical virulence factor that facilitates common bunt infection by suppressing plant immunity through the inhibition of programmed cell death, reactive oxygen species accumulation, and defense gene expression, while also protecting fungal teliospores from chitinase degradation.
This study of 34,067 adults reveals that while static and dynamic structure-function coupling follow distinct spatial aging trajectories and link differently to health, both mechanisms are crucial for cognitive flexibility and are significantly impaired by aging and APOE ε4 genetic risk, offering complementary biomarkers for neurodegeneration.
This study evaluates five computational strategies that successfully avoid the prohibitive memory and time costs of explicitly inverting the pedigree relationship matrix for single-step genomic predictions, with the Woodbury identity and stochastic Hutchinson approaches emerging as the most efficient methods for scaling approximate reliability calculations to large genotyped populations while maintaining high numerical accuracy.
Hyperglycemia exacerbates *Burkholderia cepacia* infection in K562 cells by disrupting TCA cycle flux and inducing mitochondrial dysfunction, which depletes antioxidant defenses and triggers an NLRP3 inflammasome-mediated inflammatory response via the mTOR-Akt signaling axis.
This study utilizes longitudinal single-cell RNA sequencing of peripheral blood and bronchoalveolar lavage fluid to reveal that fatal ARDS is characterized by compartment-specific immune remodeling, including a progressive peripheral T cell–monocyte imbalance with monocyte metabolic reprogramming and distinct airway myeloid microenvironmental changes, which collectively drive adverse clinical trajectories.
This study demonstrates that river dams in Japan effectively restrict the upstream dispersal of invasive *Neocaridina davidi* shrimps, thereby protecting native *N. denticulata* populations from hybridization and genetic introgression, while highlighting the need for caution in river restoration projects to prevent further non-native spread.
This study demonstrates that RANKL promotes thyroid cancer bone metastasis by inducing DNA damage through the ER stress–Hedgehog signaling axis, suggesting that targeting this network offers a novel therapeutic strategy.
This study reveals that the marsh plant *Typha domingensis* adapts to oxygen-poor sediments through a sophisticated, coordinated remodeling of carbon metabolism and root barrier chemistry that preserves protective structures while suppressing bulk lipid biosynthesis, offering new design principles for engineering climate-resilient crops.
This study reveals that while reduced fingertip-ball friction generally impairs pitching accuracy by lowering hand velocity, some pitchers successfully maintain accuracy through kinematic adaptations like increasing pitching radius and exhibiting robust, condition-independent activation of specific forearm muscles.