🧬 Category

q-bio

4041 papers

🧬 biology

Brain-inspired Spiking Neural Network Frameworks for Multimodal Spatiotemporal Brain Data Integration: A Case Study on EEG-fMRI Data

This study proposes a biologically inspired Spiking Neural Network framework utilizing early, intermediate, and a novel explainable X-Meta late fusion strategy to effectively integrate heterogeneous EEG and fMRI data, demonstrating superior accuracy and biological interpretability in decoding eyes-open versus eyes-closed brain states compared to conventional machine learning approaches.

Nida Shahab, Maryam Doborjeh, Nikola Kasabov, Iqra Shahab, Zohreh Doborjeh2026-08-20
🧬 biology

USUV exposure, determinants and immunity after the 2018 epizootic among captive birds in French zoos

Following the 2018 Usutu virus epizootic in France, a study of 366 captive birds across 13 zoos revealed a 35% overall seroprevalence driven by factors such as species susceptibility, geographic location, and biosafety measures, while demonstrating that surviving birds maintained stable, long-term neutralizing antibodies.

Antoine Leclerc, Benoit Quintard, Valentine Fantuzzi, Alexis Maillot, Jennifer Lahoreau, Karin Lemberger, Cécile Beck, R (…)2026-08-20
🧬 biology

Taxonomically standardized iNaturalist records reveal broad-scale patterns in documented polychaete diversity across U.S. coastlines

This study demonstrates that taxonomically standardized iNaturalist records can reveal broad-scale patterns in documented polychaete diversity across U.S. coastlines, highlighting significant regional differences in species composition and sampling effort while underscoring the necessity for expert validation and careful interpretation of citizen-science data for taxonomically challenging marine invertebrates.

Andrew Davinack, Leslie Harris2026-08-20
🧬 biology

miR-325-3p Facilitates Tumorigenesis and Acquired Pemigatinib Resistance in Intrahepatic Cholangiocarcinoma via Targeting ADH1B through Epithelial–Mesenchymal Transition and PI3K/AKT Signaling

This study identifies miR-325-3p as a critical oncomiR in intrahepatic cholangiocarcinoma that drives tumorigenesis and acquired pemigatinib resistance by directly suppressing ADH1B to activate the PI3K/AKT signaling pathway and epithelial–mesenchymal transition.

TENG ZHAO, JIANNAN ZHAO, ANQI DUAN, LIANGHE YU, JIAN LIU, BIN ZHU2026-08-20
🧬 biology

Modelling the polygenicity and clinical heterogeneity of human depression in mice to identify biomarkers predictive of treatment response

This study introduces two distinct polygenic mouse models of major depressive disorder, H-TST and H-FST, which recapitulate different clinical subtypes with divergent antidepressant responses and gene expression profiles, thereby enabling the identification of biomarkers that accurately predict treatment outcomes in human patients.

Stéphane Jamain, Claire Altersitz, Sébastien Arthaud, Martine Dubois, Jean-Marie Vaugeois, Malika El Yacoubi2026-08-20
🧬 biology

Immunogenicity evaluation of mutant peptides identified from lung cancer patients

This study identifies three mutant peptides (PLVAP, MBOAT7, and Neurofascin) from lung cancer patients that function as shared neoantigens capable of inducing potent, cross-reactive T and B cell responses, thereby supporting their potential use in developing personalized immunotherapies.

Jianyi Yang, Ying Xin, Jiahua Liu, Dyke P McEwen, Elizabeth Gensterblum-Miller, Alfred E. Chang, Qianchuan Liu, Xiaoqian (…)2026-08-20
🧬 biology

SCoV: a frame-gated cross-modal model for identifying viral sequences in short metagenomic fragments

SCoV is a compact, frame-gated cross-modal neural network that accurately identifies short viral sequences in metagenomic data by jointly encoding nucleotide and six-frame codon representations without requiring explicit ORF annotation, achieving superior performance and generalization across diverse habitats compared to existing baselines.

Jianhua Zheng, Wentao Tang, Shuting Yang, Junhao Lan, Jinfang Liu, Zhaoxi Luo, Wenjun Liu, Jun He, Ming Liao2026-08-20
🧬 biology

Metabolic decoupling of growth and hydrolytic enzyme production in Bacillus amyloliquefaciens SLBD under different carbon sources

This study demonstrates that *Bacillus amyloliquefaciens* SLBD exhibits metabolic decoupling between growth and hydrolytic enzyme production depending on the carbon source, with glycerol maximizing biomass and protease/lipase yields while inulin hydrolysate induces cellulase activity, enabling the selective partial purification of these enzymes for cost-effective multi-enzyme systems.

Epi Taufik, Rifqi Hafidz Ash Shiddiq, Haslina Asis, Muhamad Arifin, Slamet Widodo, Huda Shalahudin Darusman, Rafida Raaz (…)2026-08-20
🧬 biology

PfRab5a defines a divergent trafficking pathway required for apical organelle biogenesis in Plasmodium falciparum

This study reveals that the malaria parasite *Plasmodium falciparum* repurposes the canonical endocytic regulator PfRab5a to control a unique trafficking pathway essential for the de novo biogenesis of apical secretory organelles required for host cell invasion.

Tim Gilberger, Guilherme Farias, Leah Zink, Thilo Page, Nick Piwon, Joëlle Mesén-Ramírez, Yangyang Guo, Christian Löw, D (…)2026-08-20