1820 papers
This study provides the first sequence-specific backbone resonance assignments for the α-Crystallin Domain of Human Heat Shock Protein B8 (HSPB8) under fully denatured and folding conditions, establishing a molecular foundation for future investigations into its chaperone function and conformational dynamics.
This study utilizes histomorphological analysis to characterize the hormonally driven, sequential cellular remodeling of the mouse uterus from the estrus phase through early gestation, highlighting the coordinated interactions between maternal tissues and the developing embryo that facilitate implantation, decidualization, and placentation.
This study reveals that in MEF2D-rearranged B-cell precursor acute lymphoblastic leukemia, mitochondrial ROS-driven HMGB1 release establishes a positive feedback loop with autophagy to promote immune evasion and leukemic survival, a process that can be therapeutically targeted using glycyrrhizin.
This study demonstrates that motor expertise reorganizes neural dynamics by shifting reliance from broad predictive execution to efficient error-correction mechanisms, supported by specific microstructural adaptations in cortical and cerebellar networks.
This study systematically profiles nine prime editor variants to establish that PE6b and PE6c offer superior generalizable efficiency and specificity, while introducing the DeepPrime6 predictive model and optimized epegRNA strategies to guide the design of effective therapeutic prime editors.
This study elucidates the pupal morphogenesis of the Drosophila antennal auditory structure by detailing the invagination of the a2-a3 joint epidermis, the development of the sensory organ's connection to the exoskeleton, and the identification of *big brain* expression in the joint epidermis as a potential component of the underlying genetic pathway.
This study analyzes longitudinal multi-omics data from 553 Hong Kong participants to reveal that the mRNA-based BNT162b2 vaccine induces more profound, durable, and interconnected immune and metabolic changes compared to the inactivated CoronaVac, while demonstrating that baseline multi-omics profiles can predict individual vaccine responses.
This study demonstrates that a synthetic long peptide vaccine targeting conserved SARS-CoV-2 epitopes from Spike, Nucleocapsid, and Membrane proteins induces robust T cell responses and confers protection against lethal viral challenge in preclinical mouse models, even in the absence of neutralizing antibodies.
This study demonstrates that in temperate-subtropical transition forests, ectomycorrhizal tree dominance drives aboveground biomass accumulation and maintains species diversity by reducing stand structural heterogeneity, thereby revealing a novel mechanistic pathway for the biodiversity–ecosystem function relationship.
This study demonstrates that the performance advantage of an external focus of attention in a VR punching task is preserved regardless of haptic feedback, challenging the common coding theory explanation and supporting an ecological perspective that emphasizes attunement to task-relevant dynamic relations.