4041 papers
This study analyzes data from 7,576 participants aged 3 to 91 to demonstrate that age-related changes in inhibitory control, measured by reaction time and error types in a Go/No-Go task, vary significantly across the lifespan and depend on specific task demands.
This study reveals that hystricognath rodents have evolved a unique, stepwise restructuring of glucose homeostasis through coordinated positive selection on insulin and inceptor genes, coupled with lineage-specific regulatory silencing and pseudogenization of the insulin receptor (INSR-B), resulting in diverse compensatory expression patterns across species like the degu, capybara, and guinea pig.
This post-hoc analysis reveals that monocyte-derived macrophages exhibit sex-specific differences in baseline and cannabis-associated inflammatory gene expression, particularly within the NLRP3 and TREM2 pathways, with females showing higher baseline levels and distinct responses to cannabinoid stimulation compared to males.
This study demonstrates that the Smad adaptor protein SARA acts as a critical suppressor of hepatic stellate cell activation and liver fibrosis, as its loss exacerbates pathological matrix accumulation and disease progression in experimental models.
This study demonstrates that ventilation, mosquito holding cage geometry, and mesh structure significantly influence mosquito exposure to passive spatial emanators in Peet–Grady chamber assays, highlighting the critical need to standardise these parameters for reliable bioefficacy testing.
This study identifies a naturally occurring heterozygous G731R mutation in the RIG-I helicase motif VI that causes life-threatening COVID-19 by acting as a dominant-negative variant which binds viral RNA but fails to undergo the necessary conformational changes for signaling, thereby trapping the receptor in an inactive state and competitively inhibiting wild-type RIG-I function.
This study reveals a significant shared genetic architecture between essential tremor and Parkinson's disease, identifying 58 independent loci and prioritizing specific genes and biological pathways that explain their clinical overlap and the increased risk of developing Parkinson's disease in individuals with essential tremor.
This study establishes and comprehensively characterizes PUMC-DDCS1, a novel patient-derived cell line of dedifferentiated chondrosarcoma that exhibits high tumorigenicity, distinct multi-omics profiles, and specific drug sensitivities, serving as a valuable model for preclinical research and revealing the therapeutic potential of plectin inhibition via the AKT/ERK pathway.
This paper presents a theoretical model of the mitotic spindle that explains the significant discrepancy between the large forces required to stall kinetochores in anaphase versus the smaller forces observed during prometaphase, while also predicting that the total stalling force for all kinetochores is approximately four times greater than the force needed to stall a single kinetochore.
This study demonstrates that dividing attention during force acquisition significantly impairs the accuracy of reproducing low-intensity (5% MVC) forces compared to moderate-intensity (20% MVC) forces, suggesting that low-force reproduction relies more heavily on cognitive resources due to reduced proprioceptive signal clarity.