🧬 biology

Foraging movements rather than migrations drive avian influenza (HPAIV H5N1) dynamics in Antarctic seabirds

This study reveals that while HPAIV H5N1 likely entered Antarctica via South Georgia, its subsequent regional spread among seabirds was driven primarily by local foraging movements and breeding-season connectivity rather than long-distance migration.

Simeon Lisovski, Anne Günther, Christiane Boeckel, Sten Calvelage, Amandine Gamble, Ulrike Herzschuh, Thijs Kuiken, Thom (…)2026-06-24
🧬 biology

Genome-wide association studies disclosed LePC4 gene as a negative regulator of protein content in shiitake mushroom, Lentinula edodes

This study identifies LePC4 as a negative regulator of crude protein content in *Lentinula edodes* through genome-wide association and transcriptomic analyses, demonstrating that its suppression significantly increases protein levels without compromising mycelial growth, thereby offering a promising target for breeding high-protein mushroom strains.

Chenjie Xu, Wei Zheng, Tianji Huang, Jian Zhang, Yang Xiao2026-06-24
🧬 biology

TMEM119+ microglia MHC class I restricted antigen presentation impacts CD8 T cell memory, effector status, and blood-brain barrier disruption during neurotropic virus infection

This study demonstrates that microglia-specific MHC class I molecules (H-2Kb and H-2Db) play distinct and critical roles in regulating CD8 T cell proliferation, effector functions, memory recall, and blood-brain barrier disruption during neurotropic virus infection and subsequent clearance.

Aaron Johnson, Marina Seady, Mark Maynes, Javonte Thelwell, Fang Jin, Michael Hansen, Hadley Jensen, Ryann Witter, Carle (…)2026-06-24
🧬 biology

Neuromorphic Energy-Aware Learning for Adaptive Deep Brain Stimulation

This paper introduces an energy-aware learning framework that co-optimizes actuator stimulation and inference efficiency by incorporating actuator energy into reinforcement learning rewards and deploying a compressed spiking policy on neuromorphic hardware, achieving significant reductions in both pathological oscillations and total power consumption for adaptive deep brain stimulation.

Jason Eshraghian, Binh Nguyen, Colleen Josephson, Mircea Teodorescu, Gert Cauwenberghs2026-06-24
🧬 biology

Neuroimaging Biomarkers in Motoric Cognitive Risk Syndrome: A Systematic Review of Structural, Functional, and Molecular Correlates

This systematic review of 21 cross-sectional studies identifies Motoric Cognitive Risk Syndrome as a distinct predementia condition characterized by frontoparietal cortical atrophy and cerebral small vessel disease without Alzheimer's pathology, suggesting vascular disruption of mobility-cognition networks as its underlying mechanism.

Sodiq Fakorede, Kai Cheng, Hannes Devos2026-06-24
🧬 biology

Genomic characterization of the first near-complete goat-associated Orf virus genome sequenced directly from a human clinical sample in Portugal

This study reports the first laboratory-confirmed human Orf virus case in Portugal and the first near-complete genome of a goat-associated strain sequenced directly from a human clinical sample, highlighting the utility of hybrid capture for zoonotic poxvirus surveillance and the need for a One Health approach.

Daniel Sobral, Rita Cordeiro, Ana Paula Brito, Ana Margarida Henriques, Sílvia C. Barros, Fábio Abade dos Santos, Margar (…)2026-06-24