🧬 Category

q-bio

4041 papers

🧬 biology

Ecological stratification of the human gut microbiome resolves metabolic heterogeneity via precision substrate optimization

This study introduces the S-KUHIMM, a high-throughput in vitro screening platform that resolves inter-individual metabolic heterogeneity in the human gut microbiome by revealing that targeted propionate production depends on *Bacteroides* expansion capacity while butyrate synthesis is limited by acidification-induced decoupling, thereby enabling a precision nutrition strategy that matches host-specific buffering limits with mechanistically distinct substrates.

Daisuke Sasaki, Tomoya Shintani, Yasushi Matsuki, Akihiko Kondo2026-08-20
🧬 biology

Inflammatory Yet Restrained: Context-Dependent STING–Hypoxia Relationships Define Distinct Immune Ecosystems in Glioblastoma Across Bulk, Spatial, and Single-Cell Scales

This multi-scale transcriptomic study reveals that elevated STING pathway activity in glioblastoma defines a distinct, inflamed yet immunoregulatory ecosystem characterized by increased immune infiltration and an inverse relationship with hypoxia, suggesting that effective therapeutic strategies must integrate STING-targeted immunotherapy with the modulation of the hypoxic tumor microenvironment.

Ahmed Galal Rezk2026-08-20
🧬 biology

Culture-Enriched Nanopore Metagenomics for Improved Genome Recovery and Resistome Profiling of Animal Microbiome Samples

This study demonstrates that a culture-enriched Nanopore metagenomics workflow significantly outperforms direct metagenomics in low-biomass, host-rich animal samples by reducing host DNA interference, enabling the recovery of high-quality metagenome-assembled genomes, and markedly enhancing the sensitivity and depth of antimicrobial resistance and biosynthetic gene cluster profiling.

Maria Cristina Rapi¹, Alessandro Guaraglia²·³, Stefano Raimondi⁴, Guido Grilli¹·⁵·⁶, Maria Filippa Addis¹·³·⁶2026-08-20
🧬 biology

Androglobin contributes to adaptive renal responses during dietary potassium loading

This study demonstrates that Androglobin (Adgb) modulates coordinated epithelial and endocrine adaptations during dietary potassium loading, specifically by regulating pendrin abundance and steroid hormone signaling to maintain acid–base homeostasis rather than directly controlling systemic potassium levels.

Miguel Correia, Darko Maric, Denise V. Winter, Manon Jeandel, Carina Osterhof, Océane Derivaz, Angèle Clerc, Florence Ba (…)2026-08-20
🧬 biology

Opportunistic untargeted sequencing can complement targeted viral surveillance workflows for unresolved respiratory illness in Uganda

This study demonstrates that opportunistic untargeted shotgun sequencing of unresolved respiratory samples in Uganda successfully identified clinically relevant pathogens, including Human Metapneumovirus and Human Respirovirus 1, thereby validating its utility as a complementary tool to targeted molecular surveillance for diagnosing influenza-like illness.

Fahim Yiga, Joyce Namulondo, Charity Angella Nassuna, Nicholas Owor, Joweria Nakaseegu, Bridget Nakamoga, Esther Amwiine (…)2026-08-20
🧬 biology

Genome-wide analysis of the tef GRAS gene family identifies a drought-responsive homoeologous gene pair

This study characterizes the 108-member GRAS gene family in the allotetraploid cereal tef, revealing that its expansion is driven primarily by polyploidy and tandem duplications, and identifies a specific non-DELLA homoeologous gene pair (Et_5A_042921 and Et_5B_045659) as a robust, drought-responsive candidate for functional follow-up despite containing waterlogging-associated regulatory elements.

Suhaan Thayyil2026-08-20
🧬 biology

Molecular identification of protected Magnoliaceae species: a multi-marker evaluation based on extensive sampling and genome-skimming data

This study evaluates DNA barcoding for 23 protected Magnoliaceae species using genome-skimming data, revealing that while specific chloroplast fragments outperform standard barcodes at the species level, complete plastid genomes offer superior resolution, and highlighting a critical "Species-Individual Discrepancy" that necessitates multi-marker strategies and population-level data for reliable conservation identification.

Kai Mu, Xiaoyi Cheng, Xiaoman Wang, Zhang Jin, Zhengge Zhu, Jie Zhang, Shiliang Zhou, Ruijian Wang, Chao Xu, Xueying Yan (…)2026-08-20
🧬 biology

Dysbiosis and Enterobacteriaceae-associated accumulation of antimicrobial resistance in the gut bacterial reservoir of captive sloth bear (Melursus ursinus)

This metagenomic study of 215 captive sloth bears in India reveals that captivity-associated stressors and medication lead to reduced gut microbial diversity, a highly diverse resistome, and a disproportionate accumulation of multi-drug resistance genes within Enterobacteriaceae species, posing significant risks for resistance dissemination.

Anuradha Reddy, Vedam Pruthvi Pavankumar, Vanitha Shyamili Kumar, Arun A. Sha, Sneha Narayan, S Ilayaraja, M. V. Baijura (…)2026-08-20
🧬 biology

A single NLS directs AGO1 nuclear import and shapes spatial small RNA loading and silencing outputs in Arabidopsis

This study demonstrates that a specific nuclear localization signal directs AGO1 nuclear import via IMPORTIN α2, revealing that the spatial partitioning of AGO1 between the nucleus and cytoplasm differentially regulates the loading of distinct small RNA classes and determines the efficiency of gene silencing outputs.

Nicolas Bologna, Belen Moro, Camila Engler, Victor Gonzalez-Miguel, Antonela Lavatelli, Luciano Abriata, Violeta Sanchez (…)2026-08-20