🧬 biology

Plant-part specific in vitro antibacterial activity of crude ethanolic extracts of Mangifera indica against Salmonella typhi: an exploratory laboratory study

This exploratory laboratory study demonstrates that crude ethanolic extracts of *Mangifera indica* seed kernels, but not stem bark or root, exhibit significant plant-part-specific bactericidal activity against *Salmonella typhi* in vitro, whereas combined extracts show reduced efficacy.

Ivan Ronald Omara, Juliet Kyayesimira2026-06-24
🧬 biology

Migratory phenology of the Central American humpback whale (Megaptera novaeangliae) population unit in breeding areas

This study analyzes seven years of photo-identification data to reveal that the Central American humpback whale population follows a highly consistent, asymmetric migratory pattern with a distinct southbound coastal corridor and a more direct northbound return, highlighting both the stability of this endangered population's migration and its potential vulnerability to climate-driven oceanographic shifts.

Paula Cabanilles, Raquel Ortells Bañeres, Pamela Martínez-Loustalot, Nicola Ransome, Melvin Castaneda, Katherina Audley (…)2026-06-24
🧬 biology

Associations of Serum Androgens and Prenatal Testosterone Biomarkers with Dominance, Aggression, and Strength in Women

This study of 151 young women finds that while serum androgens show generally weak associations with dominance and aggression, the prenatal androgen biomarker anogenital distance (AGD) is a more valuable predictor of these traits than the 2D:4D ratio, suggesting that androgen-behavior links in females are context-dependent and require diverse measurement approaches.

Aiden Bushell, Michael Chen, Jun Liu, Bernard Crespi2026-06-24
🧬 biology

Cumulus Expansion and Oocyte Quality Across the Pubertal Transition in Mice: Implications for Modeling Fertility Preservation in Adolescents

This study demonstrates that in a murine model simulating clinical ART conditions, key markers of oocyte competence, including cumulus expansion and aneuploidy rates, remain largely consistent across the pubertal transition, suggesting limited translational value of mice for modeling human adolescent ovarian biology in fertility preservation.

Dilan Gokyer, Luhan T. Zhou, Sophia Akinboro, Elnur Babayev2026-06-24
🧬 biology

Delayed processing of CPT-collected blood preserves transcriptomic and genomic features of propagated circulating tumor cells

This study demonstrates that using BD Vacutainer CPT tubes allows for the delayed processing of blood samples (up to 24 hours at 4°C) while effectively preserving the transcriptomic and genomic integrity of propagated circulating tumor cells, thereby overcoming a major logistical barrier in CTC research.

Jerry Xiao, Shravanthy Suguru, George Sidarous, Benjamin A. Weinberg, Reetu Mukherji, Ruth Aiwu He, Seema Agarwal2026-06-24
🧬 biology

Integrated Analysis of Bulk and Single Cell Transcriptomic Sequencing Reveals Immune Patterns of T Cell Regulation and Prognostic Biomarkers in Glioblastoma

By integrating bulk and single-cell transcriptomic data, this study identifies T cell-mediated immune heterogeneity in glioblastoma and constructs a validated five-gene prognostic model (GNG11, CD5, COL1A1, CAMK4, and BCAS4) to guide personalized clinical interventions.

Feifei Dou, Jinming Liu, Renming Yu, Xiaoguang Yuan, Shen Liu2026-06-24
🧬 biology

Vrc01-class Precursor Frequency in an African Population is Influenced by Ighv1-2 Allelic Composition and Not Malaria Exposure

This study demonstrates that in a Kenyan population, the frequency of VRC01-class HIV broadly neutralizing antibody precursors is determined by IGHV1-2 allelic composition rather than malaria exposure, while also identifying novel IGHV1-2 variants that underscore the necessity of genotyping in future germline-targeting vaccine trials.

Michelle K. Muthui, Caleb Kibet, Charity Muriuki, Yiakon Sein, Sharon Owuor, Roselyn Kinoti, Wilfrida Ogonda, Michael Mu (…)2026-06-24
🧬 biology

CInvestigating the Mechanism of the Co - regulation of Colorectal Cancer by Tumor - associated Fibroblasts and Disulfidptosis Based on Single - cell RNA Sequencing and Bulk RNA Sequencing

This study integrates single-cell and bulk RNA sequencing to identify a two-gene prognostic signature (SRPX and PRELP) linked to disulfidptosis and tumor-associated fibroblast dynamics, revealing their significant role in stratifying colorectal cancer patients and guiding potential therapeutic strategies.

Xinglong Geng, Liang Zhao, Jiexi Yang, Bo Wang, Yongbai Li, Honghong Chen, Hui Luo, Qing Li, Qinyu Li, Yonghui Wang, Kai (…)2026-06-24