1820 papers
This study utilized next-generation sequencing to identify a distinct serum exosomal miRNA profile in colorectal cancer patients with liver metastasis, revealing that specific differentially expressed miRNAs regulate metastasis through signaling pathways involving key targets like PIK3R1, CDC42, and CBL.
This study introduces a knowledge graph-guided transcriptomic framework that identifies a robust 22-gene prognostic signature for cervical cancer, demonstrating superior risk stratification and independent validation compared to traditional clinical staging and conventional biomarker discovery methods.
This study demonstrates that long-term low-magnitude mechanical loading exacerbates age-related temporomandibular joint degeneration by downregulating TRPV4, which in turn suppresses chondrogenic factors like SOX9 and disrupts extracellular matrix metabolism.
This 20-year retrospective study of 2,246 individuals from a Palestinian laboratory archive reveals that nearly half of the tested population carries *MEFV* variants, with five specific mutations—led by the unusually prevalent V726A—accounting for over 94% of the genetic burden, thereby supporting the implementation of focused screening and genetic counseling strategies for Familial Mediterranean Fever in this high-prevalence population.
This study utilizes metagenomic immunoglobulin sequencing to demonstrate that Honghe cattle possess superior gut immune function and lower pathogen loads compared to commercial Simmental cattle, a trait significantly associated with high levels of IgA coating on specific bacterial strains like *Phyllobacterium myrsinacearum* and *Arcanobacterium*.
This multi-cohort bioinformatics study identifies Myo-inositol oxygenase (MIOX) as an independent poor prognostic biomarker in breast cancer that drives cell cycle progression, remodels the immune microenvironment into a state of coexisting activation and suppression, and predicts sensitivity to specific targeted therapies.
This study establishes a comprehensive, breed-resolved pan-genome framework for porcine endogenous retroviruses (ERVs) across five pig assemblies, revealing that while most ERVs are degraded, a core set of breed-shared, tissue-specific ERV-associated genes overlaps with key agricultural QTLs and offers critical benchmarks for improving xenotransplantation safety.
This study utilizes cryo-EM and functional assays to reveal how Syncytin-1 selectively binds the ASCT2 transporter in an outward-oriented, asymmetric state that enables cell-cell fusion while preserving residual transport activity, a specificity dictated by a broad interaction interface rather than single residues.
This study describes four new porcini mushroom species (*Boletus garhwalensis*, *B. temperatus*, *B. asiaticus*, and *B. indohimalayanus*) discovered in the Indian Himalaya, providing their detailed morphological descriptions, illustrations, and molecular phylogenetic analyses alongside a species identification key.
This study comprehensively characterizes the 82-member two-component system gene family in apple, revealing their evolutionary expansion through segmental duplication and cytokinin responsiveness, while functionally validating MdHK17 as a key regulator of bud regeneration.