4041 papers
This study demonstrates that feline hypertrophic cardiomyopathy is characterized by significant microvascular alterations, including capillary rarefaction, enlarged vessels, and disorganized architecture driven by metabolic stress and vascular developmental pathways, suggesting that microvascular dysfunction is a key driver of the disease's pathogenesis.
This study comprehensively characterizes the genomic landscape of human chromosome 11, elucidating how structural and epigenetic alterations in specific regions (11p15, 11q13, and metabolic/neuropsychiatric loci) drive the pathogenesis of imprinting disorders, cancers, metabolic diseases, and neuropsychiatric conditions.
This study found that baseline self-reported affect (PANAS) provided a more stable and consistent predictor of short-term affective change in immersive installations than EEG-derived indicators, suggesting that validated self-reports remain a practical reference when physiological data are limited or difficult to interpret.
This study demonstrates that both exogenous application and endogenous overexpression of the antimicrobial peptide LL37 promote the proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cells via the PI3K/Akt signaling pathway, provided concentrations remain within an optimal range to avoid inhibitory effects.
This study utilizes an ensemble species distribution modeling framework to demonstrate that while the Kali Tiger Reserve supports high mammal richness, significant conservation gaps exist in the surrounding non-protected forests of Uttara Kannada, highlighting the urgent need for a landscape-level management approach to maintain habitat connectivity in the Central Western Ghats.
This study demonstrates that the downregulated long non-coding RNA LINC00261 suppresses pancreatic cancer cell migration and invasion by promoting FOXA2 protein expression to inhibit the epithelial-to-mesenchymal transition (EMT) process, highlighting its potential as a novel therapeutic target.
By integrating large-scale single-cell and spatial transcriptomics with machine learning, this study maps the stemness landscape of glioblastoma to reveal its role in heterogeneity and drug resistance, ultimately identifying TUBB2B as a key regulator and promising therapeutic target for improving patient prognosis.
This study identifies CIP2A as a critical driver of postmenopausal osteoporosis that promotes pathological osteoclastogenesis via a novel CIP2A–OTUD4–HMGA1–c-Myc–PI3K/AKT axis, demonstrating that pharmacological inhibition of CIP2A effectively suppresses bone loss without major toxicity.
This study demonstrates that combining device-integrated live-cell imaging with custom-trained Cellpose models enables robust, label-free, and continuous quantification of mesenchymal stem cell proliferation and adipogenic differentiation, offering complementary strengths in accuracy and flexibility for time-resolved cellular analysis.
This study utilizes MaxEnt ecological niche modelling with 8,650 occurrence records and high-resolution environmental data to demonstrate that Land Use Land Cover, rather than climate alone, is the primary driver shaping the distribution of the malaria vector *Anopheles funestus* in Malawi, revealing increased habitat suitability in the eastern region and strong predictive performance (AUC = 0.914).