q-bio papers | Gist.Science

Loganin Attenuates Postmenopausal Osteoporosis by Directly Targeting the RANK/RANKL Interface and Coordinating the Nrf2/HO-1 Antioxidant Axis with Energy Metabolism Reprogramming in Osteoclasts

Loganin effectively attenuates postmenopausal osteoporosis by directly disrupting the RANK/RANKL interaction and coordinating a multi-target mechanism that suppresses osteoclast differentiation through the activation of the Nrf2/HO-1 antioxidant axis, inhibition of calcium signaling and energy metabolism reprogramming, and modulation of cell migration pathways.

Wei Deng, Yongchao Tang, Yihao Zhu, Fanguo Kong, Shuncong Zhang, Jiyao Luan2026-06-24

🧬 biology

Comparative plastome genomics reveals phylogeny, biogeography, and character evolution of Primula (Primulaceae)

This study utilizes a comprehensive plastome-based phylogenomic analysis of 106 *Primula* species to resolve long-standing taxonomic ambiguities, revealing that the genus's diversification was driven by Miocene–Pliocene geological and climatic events in the Qinghai-Tibetan Plateau, while its key reproductive trait, homostyly, evolved independently at least eight times as an adaptation to high-altitude pollinator scarcity.

Wan Tang, Shu-Bao Wang, Shi-Dong Wang, Rui Li, Kai-Yun Chen, Yuan Huang, Jia-Hui Chen2026-06-24

🧬 biology

A Predictive, Cumulative Framework for Multivalent Transcription Factor Specificity

This study establishes a predictive, biophysically grounded framework demonstrating that the mode of multivalent transcription factor assembly—ranging from flexible phase separation to rigid oligomerization—determines whether genomic specificity is governed by cumulative weak site density or strict geometric spacing, thereby redefining how endogenous repetitive sequences regulate gene expression.

Bing Li, Jingdong Xue, Yixuan Pan, Wanli Yang, Yuqian Feng, Xiang Xu, Siang Lv, Mingqian Hu, Qi Zhang, Ningzhe Li, Mengy (…)2026-06-24

🧬 biology

CORA: a COrrelation-Redundancy-Aware FDR adjustment with genomic applications

CORA is a novel FDR adjustment method that improves the parsimony of differential expression analysis by incorporating pairwise gene correlations into the Benjamini-Hochberg threshold to penalize redundant discoveries without sacrificing statistical power.

Joanna Zyprych-Walczak2026-06-24

🧬 biology

Structure-Guided Design of Therapeutic Antibodies Targeting SARS-CoV-2 Omicron Variants

This study demonstrates that a structure-guided computational design strategy successfully optimized the COV2-2196 antibody to restore and enhance its neutralization potency against SARS-CoV-2 Omicron variants, offering a practical framework for rapidly developing broadly effective therapeutics against evolving viral strains.

Jesper Pallesen, Jianqiu Du, Yuanhan Wu, Sukanya Ghosh, Kelly Bayruns, Roopak Sadeesh, David Weiner2026-06-24

🧬 biology

A simple mathematical model for the discontinuity in average nucleotide identity distributions in prokaryotes

This paper presents a simplified mean-field mathematical model demonstrating how the interplay between mutation, homologous recombination, and the decay of recombination efficiency with sequence divergence shapes the size, spacing, and position of the Average Nucleotide Identity (ANI) gap that defines prokaryotic species boundaries.

Sebastian Silva-Solar, Rudolf Amann, Tomeu Viver, Ramon Rossello-Mora, Javier Santibañez-Molina, Luis Miguel Rodriguez (…)2026-06-24

🧬 biology

Estrogen-related receptor alpha (ERRα) promotes gastrointestinal stromal tumor progression and epithelial-mesenchymal transition through Wnt/β-catenin

This study demonstrates that Estrogen-related receptor alpha (ERRα) drives gastrointestinal stromal tumor (GIST) progression and epithelial-mesenchymal transition by activating the Wnt/β-catenin signaling pathway, suggesting ERRα inhibition as a promising therapeutic strategy.

Ronald DeMatteo, Taylor Hartlein, Shan Zeng, Ferdinand Rossi, Montana Morris, Jonathan Sussman, Michael Beckman, Iulia B (…)2026-06-24

🧬 biology

Assessing Latent Heterogeneity in Breast Cancer Survival: A Frailty Model Approach Using METABRIC Data

Using METABRIC cohort data, this study confirms the prognostic value of PAM50 subtypes for breast cancer relapse while demonstrating through shared frailty modeling that unmeasured latent heterogeneity within these subtypes is minimal.

Sherif Mohammed, Leonard Kyei, Francis Okyere, Francis Amuyao2026-06-24

🧬 biology

Using cryopreserved coral sperm for larval production at a restoration-relevant scale

This study demonstrates that cryopreserved coral sperm can be used to produce larvae at restoration-relevant scales (up to 960,000 per litre) with fertilization success and recruit survival comparable to fresh sperm, thereby enabling the large-scale utilization of biobanked genetic resources for reef restoration.

Jonathan Daly, Rebecca Hobbs, F. Mikaela Nordborg, Andrea Severati, Line Bay, Justine O'Brien2026-06-24

🧬 biology

Implied Motion as a Mechanism for Spontaneous Belief Computation in Humans

This study demonstrates that the human brain spontaneously computes others' beliefs by encoding them as implied agent-to-object motion, a mechanism supported by intracranial EEG evidence showing shared neural processing in the temporoparietal junction for both belief tracking and visual flow.

Patricia Christian, James Cahill, Adeline Fecker, Martha Paskin, Ronja Löfström, Zane Zook, Ahmed Raslan, Kelly Collins (…)2026-06-24

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