🧬 Category

q-bio

4041 papers

🧬 biology

Polycomb Epigenetic Programs Contribute to Tic Disorder Pathophysiology Independently of Antipsychotic Drug Targets

This study demonstrates that tic disorder genetic liability is significantly enriched in Polycomb-regulated pathways governing neuronal identity, synaptic plasticity, and RNA processing—mechanisms distinct from antipsychotic drug targets—thereby offering a novel epigenetic rationale for the limitations of current treatments and identifying new targets for mechanism-based therapies.

Ngo Cheung2026-08-19
🧬 biology

Single-cell atlas of embryonic fibroblasts and the Nanog-dependent transactivation of id4 in Chinese soft-shelled turtle (Pelodiscus sinensis)

This study establishes a single-cell atlas of *Pelodiscus sinensis* embryonic fibroblasts to reveal their developmental heterogeneity and demonstrates that the pluripotency factor Nanog directly binds to and upregulates *id4* to drive stemness acquisition and proliferation in this reptilian model.

Minglian Zhao, Zhongqiu Zhu, Zeyu Zhan, Kaili Chen, Hongyan Xu2026-08-19
🧬 biology

Healthy Aging as Information Divergence in the Multiplex Brain

This study models the human brain as a multiplex network to reveal that healthy aging is characterized by a linear, spatially heterogeneous divergence where subcortical functional dynamics increasingly decouple from structural constraints, while the limbic core remains remarkably stable, offering a new connectomic baseline to distinguish normative decline from neurodegenerative disease.

Dipanjan Ray, Debika Ghosh, Lucina Uddin, Moumita Das2026-08-19
🧬 biology

Sub-100 ns transition paths in unmodified single protein measurements

This paper introduces temperature-jump nanoaperture optical tweezers (TJ-NOTs) to observe unmodified single proteins across a vast temporal range from nanoseconds to hours, revealing ultrafast sub-100 ns transitions in bovine serum albumin and bridging the gap between molecular dynamics simulations and biologically relevant timescales.

Reuven Gordon, Tianyu Zhao, Xi Ren, Edona Karakaci, Ethan Bintrim, Mert Gur, Cuifeng Ying, Michael Mayer, Robert Smith2026-08-19
🧬 biology

Continuous-time movement modelling reveals spatial memory, movement strategies and social spacing of a large herbivore in a highly degraded landscape

This study utilizes continuous-time movement models on GPS telemetry data to reveal that critically endangered hirola antelopes exhibit significant individual heterogeneity in movement strategies, spatial memory, and social spacing, providing a more accurate understanding of their space use than conventional methods and establishing a framework for future conservation efforts.

Abdullahi H. Ali, George M. Maina2026-08-19
🧬 biology

Maturation of the neonatal cortical-depth-dependent BOLD response measured using ultra-high field fMRI

Using ultra-high-field (7 Tesla) fMRI, this study demonstrates that the maturation of the cortical-depth-dependent BOLD response in newborns follows distinct spatial patterns, revealing the tight co-development of vascular architecture, neuronal function, and haemodynamics in the early human brain.

Jucha Willers Moore, Philippa Bridgen, Elisabeth Pickles, Pierluigi Di Cio, Lucy Billimoria, Ines Tomazinho, Cidalia Da (…)2026-08-19