1820 papers
This study redefines the adult human limbus as an instructive, dynamic transition zone rather than a rigid lineage barrier, demonstrating that bipotent limbal progenitors determine corneal or conjunctival fate through a molecular switch governed by KGF and EGF signaling.
This study introduces a descriptor-aware Meta-Ensemble learning framework that integrates multiple machine learning algorithms and heterogeneous descriptors to achieve robust, interpretable cross-target pharmacophore recognition for CNS-related therapeutic targets, ultimately identifying and validating novel inhibitors through virtual screening and extensive molecular dynamics simulations.
This multiscale study demonstrates that acute levodopa treatment reorganizes the Parkinsonian brain into a distinct hyperconnected state aligned with dopaminergic and serotonergic systems, rather than restoring it to a healthy control pattern, with the magnitude of this reorganization predicting individual improvements in bradykinesia.
The study introduces Chole-seq, a modular single-cell multi-omics platform that simultaneously profiles membrane cholesterol and transcriptomes to reveal a specific tumor subpopulation with coordinated cholesterol and glycan elevation that drives immune evasion and aggressive tumor growth.
This study demonstrates that FABP5 is essential for kidney resilience during acute injury, as its suppression impairs lipid metabolism and mitochondrial function, thereby exacerbating acute kidney injury severity.
The study introduces SIMALI, a novel 3D computational model that demonstrates how the spatial architecture of alveolar sacs and the initial distribution of viral infection critically determine the variability and progression of lung inflammation observed in SARS-CoV-2 patients.
This study reveals that while selecting *Acropora aff. digitifera* for adult heat tolerance incurs fitness costs in offspring under normal conditions, these trade-offs disappear under heat stress, where tolerant lineages actually demonstrate improved early-stage survival and settlement.
This study demonstrates that light quality and intensity actively regulate the reversible formation of *Synechocystis* sp. PCC 6803 biofilms and extracellular polymeric substance production, with blue-green light promoting aggregation and energy dissipation while red light favors rapid growth, highlighting the critical role of light-driven physiological plasticity in cyanobacterial adaptation.
This study demonstrates that a genetically engineered *Saccharomyces boulardii* strain displaying a surface anti-CD3 scFv (Sb649) effectively attenuates DSS-induced colitis in mice by modulating immune responses and enhancing mucosal protection, highlighting its potential as an oral delivery platform for antibody-based immunotherapies.
This study demonstrates that dietary zinc supplementation effectively counteracts simulated microgravity-induced immune suppression and significantly enhances bacterial clearance in *E. coli*-infected rats, suggesting its potential as a nutritional countermeasure for infection risks during spaceflight.