4041 papers
This study introduces the scalable PanGEtrix workflow to analyze nearly 8,000 *Vibrio parahaemolyticus* genomes, revealing an open pangenome with continuous gene acquisition that underscores the pathogen's exceptional genomic plasticity and adaptability.
This study conducted along the China-Myanmar border reveals a high prevalence of *Calodium hepaticum* infection in small mammals, particularly *Rattus* species, identifies conventional PCR as a superior detection method over tissue compression microscopy, and establishes region, species, sex, and body length as significant independent risk factors to inform "One Health" prevention strategies.
This study reveals that risk genes for five overlapping psychiatric and neurodegenerative disorders are embedded within cohesive, distributed interactome modules rather than existing as isolated nodes, with specific shared subnetworks exhibiting prenatal expression signatures and ribosome-related functions that underlie common spatiotemporal patterns across distinct clinical syndromes.
This study reveals that cerebral asymmetry follows distinct lifespan trajectories between Chinese and Western populations, demonstrating that population-matched normative models are essential for accurately assessing individual brain asymmetry and detecting deviations associated with neurological disorders.
This in vitro study demonstrates that among three common clear aligner materials, polyethylene terephthalate glycol-modified (PET-G) exhibits significantly lower *Streptococcus mutans* adhesion and biofilm formation compared to polyurethane and a hybrid blend, suggesting it is the superior choice for minimizing cariogenic bacterial buildup.
This study demonstrates that the differential antimicrobial efficacy and cytotoxicity of two matched peptide pairs (KT9 and RT9) are driven by their distinct interactions with lipid membranes, where KT9's superior bacterial killing correlates with greater membrane destabilization in bacterial models, while RT9's higher toxicity to red blood cells aligns with increased membrane fusion in eukaryotic models.
This study reveals that high levels of transposable element transcripts in Drosophila spermatocytes originate not from autonomous activation but from the introns of Y-linked fertility genes, where these elements shape chromosomal architecture and contribute to the rapid evolution of male fertility and speciation.
This study reveals that chemotherapy resistance is driven by caspase-mediated degradation of the m6A reader YTHDF2, which normally promotes the translation of m6A-modified MYC transcripts to enhance apoptotic responses to DNA-damaging agents.
Using fMRI data from the Human Connectome Project, this study reveals that individuals with right-hemisphere language dominance exhibit selective, region-specific reorganization of face-processing lateralization, demonstrating that cortical specialization is flexible rather than globally fixed.
This study demonstrates that co-culturing *Acinetobacter baumannii* with *Pseudomonas aeruginosa* induces a preconditioning-like transcriptomic shift, characterized by the pre-activation or pre-repression of specific genes that subsequently attenuate the bacterium's response to subinhibitory antibiotic treatment.