4041 papers
This paper introduces "City Walk," a VR serious game for assessing spatial navigation, and reports on a pilot study demonstrating that its Enhanced-Immersive VR configuration (combining a head-mounted display with an omnidirectional treadmill) is feasible, well-received, and yields superior route accuracy and landmark placement compared to Desktop VR, despite longer completion times.
This pilot study demonstrates that at-home capillary blood collection using the Tasso+ device yields serum proteome results comparable to standard venous draws when samples are processed immediately, and that minimizing pre-processing delays to under 48 hours and maintaining refrigeration temperatures below 4°C significantly preserves protein stability for large-scale proteomic analyses.
This study establishes a highly stringent biocontainment system for *Saccharomyces cerevisiae* by screening thousands of genomic edits to identify optimal sites for synthetic auxotrophy, ultimately combining multiple TAG codon insertions with a conditional protein stability mechanism to achieve near-wild-type fitness in permissive conditions while reducing escape frequency to 7.5×10⁻¹¹.
This study identifies the NLRP4–ER stress–CCL5 axis as a critical translational target that enhances NK cell infiltration and tumor suppression in lung cancer by establishing a positive feedback loop, offering a promising strategy to overcome current immunotherapy limitations.
This study demonstrates that an AI-driven framework combining YOLOv8 for detection and Deep-Sort for tracking can accurately automate the Racine scoring of rodent seizures, showing high precision in identifying specific seizure stages and normal behaviors to improve epilepsy research efficiency.
This paper introduces SonoMod, an open-source, transparent miniscope-integrated platform that enables concurrent focused ultrasound neuromodulation and wide-field calcium imaging in freely moving mice by utilizing a novel optically transparent transducer and lens system.
This study demonstrates that chronic cigarette smoke-induced COPD exacerbates postoperative cognitive impairment in rats with tibial fractures through hippocampal neuroinflammation, oxidative stress, and dysregulated apoptosis and autophagy.
This study establishes a novel CRISPR-based pipeline to functionally validate the osteoarthritis-associated SNP rs11780978, demonstrating that epigenetic modulation and subsequent knockout of the PLEC gene in human chondrocytes reveal its critical roles in cartilage development, homeostasis, and the cellular response to mechanical and inflammatory stress.
This study reveals that maternal Rbm24a in zebrafish orchestrates the temporal organization and homeostasis of germ granules by anchoring mRNAs in precursors and regulating their subsequent release for translation, thereby preventing germ cell transdifferentiation and ensuring fertility.
This pilot study utilized spatial transcriptomics to identify compartment-specific molecular signatures in chronic antibody-mediated kidney rejection, revealing that mononuclear phagocytes drive antigen presentation across glomerular and vascular microenvironments.