q-bio papers | Gist.Science

Atlantic and Indo-Pacific separation in Palythoa sibling species: phylogenomic analyses using ultraconserved elements

Phylogenomic analysis using ultraconserved elements reveals that the widely distributed zoantharian species *Palythoa tuberculosa* and *P. caribaeorum* do not form distinct monophyletic lineages, suggesting they represent a single species complex or incipient speciation event where genome-scale data alone is insufficient to resolve their boundaries due to recent divergence and gene tree discordance.

Lara Adele Jacobs Hansen, Maria E. A. Santos, Hiroki Kise, Nuba Zamora-Jordán, James Davis Reimer2026-08-18

🧬 biology

Biogeographical patterns in Southern Ocean Eatoniella species

This study integrates genetic, morphological, and temporal analyses to reveal that the biogeographical patterns of Southern Ocean *Eatoniella* snails are shaped by a complex interplay of ancient vicariant events linked to Antarctic isolation and more recent, albeit rare, long-distance dispersal events across the Antarctic Polar Front.

Claudio A. González-Wevar, Paula Segovia-Collao, Hugo A. Benítez, Sebastián Rosenfeld, Maximiliano Martínez, Elie Poulin (…)2026-08-18

🧬 biology

Conserved and specialized features of thalamocortical wiring revealed by single-cell projection mapping in mouse and marmoset

By combining single-cell gene expression and projection mapping in mice and marmosets, this study reveals that while primate thalamocortical circuits exhibit increased spatial segregation to support specialized connectivity, they remain fundamentally organized by conserved molecular gradients that transcend discrete anatomical borders and correlate with cortical target locations.

Xiaoyin Chen, Angela Fan, Jack Scott, Noah Kuehn, Maryam Majeed, Sabrina Cheng, Huihui Qi, Mathew Summers, John Hover, T (…)2026-08-18

🧬 biology

Discovering and decoding latent mean-field structure with variational autoencoders

This paper establishes that a successful variational autoencoder inherently learns a latent mean-field theory by demonstrating that its conditionally independent decoder structurally mirrors a finite-size mean-field factorization, thereby enabling the direct extraction of microscopic parameters and collective variables from both solvable models and experimental neural data.

Vincenzo Vitelli, Marco Biroli, Max Welling2026-08-18

🧬 biology

Ablim3 is upregulated in experimental colitis and its local knockdown attenuates DSS- induced intestinal injury in mice

This study demonstrates that Ablim3 is upregulated in experimental colitis and that its local knockdown in mice attenuates DSS-induced intestinal injury, suggesting a potential therapeutic target for inflammatory bowel disease.

Minhao Wang, Yiqun Li, Li Li2026-08-18

🧬 biology

Efficacy of Extracellular Vesicles in Organ-On-Chip Models: A Comprehensive Systematic Meta-analysis for Degenerative Diseases

This systematic meta-analysis of 12 studies (2016–2024) demonstrates that integrating extracellular vesicle-based therapies with organ-on-chip models effectively promotes tissue regeneration and reduces inflammation across diverse degenerative disease models, offering a superior, animal-free platform to accelerate regenerative medicine and personalized therapeutic development.

Himanshu K, Gunjan K, Saheem Ahmad, Paridhi Puri, Riya Mukherjee, Chung-Ming Chang, Ramendra Pati Pandey2026-08-18

🧬 biology

Bacterial DNA invasion triggers transposable element proliferation and genome expansion

This study reveals that bacterial DNA invasion via horizontal gene transfer triggers the proliferation of specific transposable elements, particularly Mavericks, leading to significant genome expansion and molecular innovation in nut weevils.

Zachary Cohen, Lindsey Perkin, Paul Frandsen, Michael DeGiorgio, Raquel Assis2026-08-18

🧬 biology

Targeting Noradrenergic Regulation of the Astrocyte–Neuron Lactate Shuttle in Recognition Memory

This study demonstrates that noradrenergic enhancement of object recognition memory relies on astrocyte-specific β₂-adrenergic receptor signaling to drive the astrocyte–neuron lactate shuttle, where astrocyte-derived lactate is essential for memory consolidation.

Lorena Roselló-Jiménez, Raúl Pastor, Marta Miquel, Nina Vardjan, Laura Font2026-08-18

🧬 biology

Spatial Resampling Obscures Temporal Change in Malaria Prevalence: Evidence from Simulated Malaria Indicator Surveys

This study demonstrates that randomly resampling survey locations between Malaria Indicator Survey rounds introduces significant spatial noise that obscures true temporal trends in malaria prevalence, whereas retaining fixed locations across years substantially improves the precision of change estimates.

Richard Kamwezi, Donnie Mategula, Michael Give Chipeta, Michelle Stanton2026-08-18

🧬 biology

Seasonality shapes host associations and functional potential of virome in a brackish water lagoon

This study presents the first comprehensive metagenomic analysis of the viral community in Chilika Lake, revealing that monsoon-driven seasonal changes primarily shape viral host associations, community structure, and functional potential, with a predominantly lytic lifestyle targeting key bacterial and eukaryotic hosts to influence biogeochemical cycling.

Govindhaswamy Umapathy, Samuel Singh, Manisha Ray, Shivakumara Manu2026-08-18

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