🧬 biology

Reconstructing the brain’s language network from non-invasive EEG enables interpretable speech decoding

This paper presents an interpretable framework that reconstructs brain language network dynamics from non-invasive EEG using neural perturbational inference and cortical eigenmodes to achieve state-of-the-art, physiologically grounded speech decoding with significantly reduced error rates and distinct electrophysiological signatures for error correction.

Nan Yan, zhao shuzhi, Yunchao Min, Jianwu Dang, Changsong Zhou, Lan Wang2026-08-18
🧬 biology

MoO₂-Coated Photonic Crystal Fiber Biosensor for High-Sensitivity Detection of Cancer Cells

This paper proposes a high-sensitivity surface plasmon resonance biosensor utilizing a MoO₂-coated photonic crystal fiber, which achieves a maximum wavelength sensitivity of 17,295.78 nm/RIU and successfully distinguishes six types of cancer cells through optimized structural design and numerical simulation.

Qi Zhai, Yang Zhang, Shuhuan Zhang, Yufan Sun, Jingqi Zhang, Siying Chen, Zuolong Li, Minghang Man, Xingyang Xu, Min Pen (…)2026-08-18
🧬 biology

Amplified Trunk-Head Contribution to Whole-Body Angular Momentum Under Perturbed Conditions

This study demonstrates that during gait perturbations, the trunk-head segment significantly amplifies its contribution to whole-body angular momentum while lower limb contributions decrease, suggesting that trunk coordination serves as a critical compensatory mechanism for maintaining stability, particularly in the frontal plane.

Maria-Elissavet Nikolaidou, Christos Theodorakis, Lida Mademli, Falk Mersmann, Sebastian Bohm, Adamantios Arampatzis2026-08-18
🧬 biology

Akkermansia-associated microbial modules and functional metabolic axes link gut microbiome to adiposity across humans and mice

This study demonstrates that *Akkermansia muciniphila* functions not as an isolated taxonomic marker but as a component of a reproducible microbial module and energy/carbon metabolic axis that more consistently links the gut microbiome to adiposity across humans and mice than the bacterium's abundance alone.

Junfeng Shi, Huihui Song, Kexin Zhang, Hongyan Qiu, Yujie Ma, Ningning Hou, Xiaodong Sun2026-08-18
🧬 biology

Selective detection of 13CH signals from the mixture of 13CH/13CH2/13CH3 groups in biomolecules with enhanced sensitivity

This paper presents an optimized CH-selective 1H–13C HSQC pulse scheme that utilizes one-bond scalar coupling evolution, cross-polarization, and PEP methodology to selectively detect 13CH signals with enhanced sensitivity while effectively suppressing interfering 13CH2 and 13CH3 signals in biomolecules.

Tairan Yuwen, Zhilian Xia, Jiangshu Liu, Yixin Cui, Jitendra Das, Youlin Xia, Paolo Rossi, Charalampos G. Kalodimos2026-08-18
🧬 biology

Cell-resolved transcriptomics separates the components of a pathway- wide PI3K–AKT response in dilated cardiomyopathy: the AKT1 change localizes to cardiomyocytes, the PIK3CA change peaks in fibroblasts

Using single-nucleus RNA sequencing to overcome the limitations of bulk tissue analysis, this study reveals that the PI3K–AKT pathway response in dilated cardiomyopathy comprises distinct, cell-type-specific components—specifically an AKT1 upregulation restricted to cardiomyocytes and a PIK3CA increase peaking in fibroblasts—rather than a unified, validated therapeutic target.

Yingying Qian, Haitao Tian, Shuaihong Zhao, Yanjiao Bian, Hongyang Yu, Ang Di, Yingshuang Jia, Shaodan Li, Runquan Sun2026-08-18
🧬 biology

Lipidomic Remodeling during Lipid-Rich Mammalian Oocyte Maturation and Early Embryo Development

Using pigs as a lipid-rich model, this study elucidates the specific roles of triglyceride lipolysis and phosphatidic acid in oocyte maturation and blastocyst formation, ultimately demonstrating that moderate overexpression of hormone-sensitive lipase significantly improves the cryopreservation survival rates of lipid-rich mammalian embryos.

Yi-Liang Miao, Xin Liu, Suming Chen, Ruifeng Hu, Pujia Zhu, Xiaoyu Chu, Xin Yang, Kai Zhou, Tingting Wang, Yan Shang, Zh (…)2026-08-18