4119 papers
This study introduces a novel DIA-centric workflow (Glyco-DIA 2.0) to generate the first region-resolved quantitative atlas of O-GalNAc glycosylation across nine mouse brain compartments, revealing site-specific regulatory patterns on key neuronal proteins and providing an interactive public resource to explore this spatial layer of brain molecular architecture.
This study analyzes the gut resistomes of young adults from 34 countries to reveal that while the overall burden of antimicrobial resistance is primarily driven by temperature, the specific composition of resistance genes is shaped by continental location, dietary patterns, and veterinary antibiotic use, highlighting the need for region-specific stewardship strategies.
This study reveals that Arylsulfatase B (ARSB) regulates RAS-GTPase activity by modulating oncofetal chondroitin sulfate levels and galectin-3 interactions, thereby influencing EGFR expression and suggesting a novel therapeutic strategy for inhibiting RAS-driven malignancies.
This study sequenced and analyzed 17 complete chloroplast genomes of *Vanilla* species to identify highly variable molecular markers and genes under positive selection, thereby confirming the genus's monophyly and providing critical genomic resources for its phylogenetic, taxonomic, and conservation research.
This study demonstrates that integrating novel remote sensing data, such as GEDI LiDAR-derived canopy height and hyperspectral foliar traits, significantly enhances the accuracy and interpretability of models predicting bird vocal activity across California's Sierra Nevada by capturing nuanced, species-specific habitat requirements.
This longitudinal study demonstrates that in older adults, the apparent ten-year drift in blood DNA methylation is primarily driven by time-varying changes in leukocyte composition rather than intrinsic epigenetic aging, as adjusting for cell type shifts largely eliminates the observed methylation velocity.
This cross-sectional secondary analysis reveals that while sample entropy did not differentiate groups, median frequency asymmetry in the vastus lateralis muscle persists in the involved limb of ACL-reconstructed patients compared to healthy controls during isokinetic exercise, suggesting it could complement traditional torque-based assessments.
This study utilizes mixed-effects modeling on a large dataset from a four-arm restless bandit task to characterize trial-by-trial observable behavioral adaptation, revealing distinct nonlinear trajectories in decision-making across different payoff environments without inferring latent cognitive mechanisms.
This paper introduces "City Walk," a VR serious game for assessing spatial navigation, and reports on a pilot study demonstrating that its Enhanced-Immersive VR configuration (combining a head-mounted display with an omnidirectional treadmill) is feasible, well-received, and yields superior route accuracy and landmark placement compared to Desktop VR, despite longer completion times.
This pilot study demonstrates that at-home capillary blood collection using the Tasso+ device yields serum proteome results comparable to standard venous draws when samples are processed immediately, and that minimizing pre-processing delays to under 48 hours and maintaining refrigeration temperatures below 4°C significantly preserves protein stability for large-scale proteomic analyses.