🧬 Category

q-bio

4083 papers

🧬 biology

Cell-resolved transcriptomics separates the components of a pathway- wide PI3K–AKT response in dilated cardiomyopathy: the AKT1 change localizes to cardiomyocytes, the PIK3CA change peaks in fibroblasts

Using single-nucleus RNA sequencing to overcome the limitations of bulk tissue analysis, this study reveals that the PI3K–AKT pathway response in dilated cardiomyopathy comprises distinct, cell-type-specific components—specifically an AKT1 upregulation restricted to cardiomyocytes and a PIK3CA increase peaking in fibroblasts—rather than a unified, validated therapeutic target.

Yingying Qian, Haitao Tian, Shuaihong Zhao, Yanjiao Bian, Hongyang Yu, Ang Di, Yingshuang Jia, Shaodan Li, Runquan Sun2026-08-18
🧬 biology

Lipidomic Remodeling during Lipid-Rich Mammalian Oocyte Maturation and Early Embryo Development

Using pigs as a lipid-rich model, this study elucidates the specific roles of triglyceride lipolysis and phosphatidic acid in oocyte maturation and blastocyst formation, ultimately demonstrating that moderate overexpression of hormone-sensitive lipase significantly improves the cryopreservation survival rates of lipid-rich mammalian embryos.

Yi-Liang Miao, Xin Liu, Suming Chen, Ruifeng Hu, Pujia Zhu, Xiaoyu Chu, Xin Yang, Kai Zhou, Tingting Wang, Yan Shang, Zh (…)2026-08-18
🧬 biology

Systems Biology of Gut Microbiome Dysbiosis in Major Depressive Disorder: Functional Microbial Networks Linked to Inflammation, Illness Severity, Recurrence, and Suicidal Behavior

This study demonstrates that major depressive disorder is characterized by a functional restructuring of the gut microbiome, where specific inflammatory and barrier-disrupting microbial networks significantly correlate with illness severity, recurrence, and suicidal behavior through neuroimmune, metabolic, and oxidative stress (NIMETOX) pathways.

Changyang Meng, Jing Li, Mengqi Niu, Abbas F. Almulla, Yiping Luo, Andre F Carvalho, Annabel Maes, Yingqian Zhang, Micha (…)2026-08-18
🧬 biology

Intra-male reduction in sperm size persists during growth in cuttlefish despite the absence of insemination-site dimorphism

This study demonstrates that in cuttlefish, the intra-male reduction in sperm flagellar length during growth occurs despite the absence of insemination-site dimorphism, suggesting that the competitive pressures faced by smaller "sneaker" males drive the evolution of costly sperm traits independent of distinct sperm storage sites.

Kyohei Kudamatsu, Noritaka Hirohashi2026-08-18
🧬 biology

Speech Foundation Models for Parkinson’s Disease Detection: A Layer-Wise Comparison with Handcrafted Acoustics Across Two Cohorts

This study demonstrates that speech foundation models, particularly when utilizing intermediate-to-late encoder layers and soft-voting aggregation, outperform handcrafted acoustic features in detecting Parkinson's disease from sentence reading across two independent cohorts, though they still exhibit demographic performance disparities and show more variable results on sustained vowels.

Hadi Sedigh Malekroodi, Byeong-il Lee, Myunggi Yi2026-08-18
🧬 biology

Ancient genomics reveals lost giant chaffinch ecomorphs in the Azores

Ancient genomic analysis of fossil remains from the Azores reveals that extinct giant chaffinch ecomorphs, which morphologically resembled Canary Islands blue chaffinches, actually evolved from the extant Azorean common chaffinch lineage, demonstrating that significant morphological divergence can occur without substantial genome-wide divergence.

Juan Carlos Illera, B. Karina Montero, Juan Carlos Rando, Josep Antoni Alcover, Carles Lalueza-Fox, Martin Irestedt, Car (…)2026-08-18
🧬 biology

IndepMR: An Ontology-Driven, Ancestry-Aware Interactive R Shiny Framework for Automated Two-Sample and Multivariable Mendelian Randomization with Mediation Analysis Using Public GWAS Summary Data

IndepMR is a novel, open-source R Shiny framework that automates two-sample, multivariable, and mediation Mendelian Randomization analyses by integrating ontology-driven trait retrieval and a rigorous ancestry-matching engine to ensure reproducible causal inference using public GWAS summary data.

T. P.B. Yatawara¹, D. S. Wickramarachchi¹2026-08-18
🧬 biology

Integrative bulk, single-cell and spatial transcriptomics characterizes the immune context of proliferative recurrence risk in early lung adenocarcinoma

This study integrates bulk, single-cell, and spatial transcriptomics to demonstrate that a cell-cycle program score (CCPS) in early-stage lung adenocarcinoma predicts recurrence risk while correlating with an immune-engaged and immunoregulatory transcriptional context, though the findings do not yet establish clinical predictive utility or causal immune regulation.

Yaxuan Liu, Ruijiang Lin, Ning Wei, Songla Bai, Liangliang Yang, Jiacheng Su, Diego Gonzalez Rivas, Minjie Ma, Biao Han2026-08-18